{"id":"hum0369","version":1,"url":"https://humandbs.dbcls.jp/research/hum0369/v1","datePublished":"2022-09-28","versions":[{"version":1,"datePublished":"2022-09-28"}],"title":{"ja":"医療従事者の新型コロナウィルス感染抵抗性についての検討","en":"A study of resistance to novel coronavirus infection in health care workers"},"summary":{"aims":{"ja":"茨城県においても、複数の病院において医療従事者の院内感染と思われる事例が発生した。感染した医療従事者については、感染者との濃厚接触により発症したものと想定されるが、明らかに感染した医療従事者よりも濃厚接触したにもかかわらず、感染に至らない医療従事者が多数いることを確認した。そこで、新型コロナウィルス感染症に対して罹患しにくい個人の内的要因、ならびにストレス耐性を明らかにすることで、医療従事者の適正配置に加え、今後の本症の対応に対し、より安全に対処可能な体制作りの実現を目的とした。","en":"There have been cases of what appear to be nosocomial infections among healthcare workers at several hospitals. The infected healthcare workers were assumed to have contracted the disease through close contact with infected patients. However, we confirmed at each hospital that there were many healthcare workers who had apparently had closer contact with infected patients than the infected healthcare workers but had not contracted the disease. The purpose of this study was to clarify the internal factors that make individuals less susceptible to novel coronavirus infection and their stress tolerance and to establish a system that contributes to the appropriate allocation of healthcare workers and the creation of a system that can more safely deal with this disease in the future."},"methods":{"ja":"末梢血より抽出したゲノムDNAを用いたアンプリコンシーケンス解析","en":"Amplicon sequencing was performed using genomic DNA purified from peripheral blood."},"targets":{"ja":"新型コロナウイルス感染者に濃厚接触したものの、罹患しなかった健常者：139名","en":"139 healthy individuals who had contacted patients infected with novel coronavirus but did not contract novel coronavirus"},"url":{"ja":[{"url":"https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000047878","text":"https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000047878"}],"en":[{"url":"https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000047878","text":"https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000047878"}]}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"健常者：139名\n（日本人）","en":"139 healthy persons\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Target Capture）","en":"NGS\n(Target Capture)"}},"releaseNote":{"ja":"新型コロナウイルス感染者に濃厚接触したものの、新型コロナウイルスに罹患しなかった健常者139名の末梢血から抽出したDNAを用いた5遺伝子（TMPRSS2、MxA、ACE2、IFNL3、IFNL4）のTarget Capture Sequencing解析データをfastqファイルにて提供する。","en":"DNAs extracted from peripheral blood cells of 139 healthy individuals who had contacted a person infected with novel coronavirus but who did not contract novel coronavirus were used for the target capture sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"川口 敦史","en":"Atsushi Kawaguchi"},"organization":{"name":{"ja":"筑波大学 医学医療系 ウイルス学","en":"Division of Molecular Virology, Faculty of Medicine, University of Tsukuba"}}}],"researchProjects":[],"grants":[{"title":{"ja":"COVID-19感染症の診療にあたる医療従事者の保護対策の確立に向けた研究","en":"Study to establish protective measures for health care workers treating COVID-19 infections"},"agency":{"ja":"厚生労働科学研究費補助金 厚生労働科学特別研究","en":"Health, Labour and Welfare Sciences Research Grants for Special Research"},"grantIds":["20CA2055"]}],"relatedPublications":[{"title":"TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility","doi":"https://doi.org/10.3389/fmicb.2022.943877","datasets":["JGAD000684"]}],"datasets":["JGAD000684"],"controlledAccessUsers":[]}