{"id":"hum0360","version":1,"url":"https://humandbs.dbcls.jp/research/hum0360/v1","datePublished":"2022-12-21","versions":[{"version":1,"datePublished":"2022-12-21"}],"title":{"ja":"COVID-19 発病・重症化機構の探索的研究","en":"Exploratory research on COVID-19 pathogenesis and aggravation"},"summary":{"aims":{"ja":"日本国内でのCOVID-19罹患者から得られた検体を用いた研究により、その病態をシングルセルレベルで明らかにすること","en":"To understand the mechanism of the pathogenesis of COVID-19 at the single-cell level"},"methods":{"ja":"COVID-19罹患者の血液試料から分離されたPBMCを用いた、シングルセル解析","en":"Single-cell analyses were performed using PBMCs from COVID-19 patients."},"targets":{"ja":"COVID-19罹患者から採取した末梢血","en":"Blood samples from COVID-19 patients"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"COVID-19：6症例\n（日本人）","en":"COVID-19: 6 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（scRNA-seq、scVDJ-seq）","en":"NGS\n(scRNA-seq, scVDJ-seq)"}},"releaseNote":{"ja":"COVID-19罹患者6名の末梢血単核球（PBMC）から抽出したRNAを用いたscRNA-seq解析ならびにscVDJ-seq解析の結果をfastqファイル形式で提供する。","en":"RNAs extracted from PBMCs from COVID-19 patients were used for the single-cell RNA sequencing and single-cell VDJ sequencing analyses. Fastq files are provided."},"dataProviders":[{"name":{"ja":"立川 愛","en":"Ai Tachikawa"},"organization":{"name":{"ja":"国立感染症研究所 エイズ研究センター","en":"AIDS Research Center, National Institute of Infectious Diseases"}}}],"researchProjects":[],"grants":[{"title":{"ja":"感染病原体の網羅的同定と感染宿主応答の関連解析","en":"Comprehensive survey of infectious microorganisms and the investigation of host responses against microorganism infections"},"agency":{"ja":"日本医療研究開発機構（AMED） 新興・再興感染症に対する革新的医薬品等開発推進研究事業","en":"Research Program on Emerging and Re-emerging Infectious Diseases, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP22fk0108146"]},{"title":{"ja":"病理学的アプローチによる先天性感染症・原因不明感染症診断法の開発","en":"Development of pathological diagnostic methods for congenital infections and unexplained illness of possible infectious etiology"},"agency":{"ja":"日本医療研究開発機構（AMED） 新興・再興感染症に対する革新的医薬品等開発推進研究事業","en":"Research Program on Emerging and Re-emerging Infectious Diseases, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP19fk0108104"]}],"relatedPublications":[{"title":"Multimodal single-cell analyses of peripheral blood mononuclear cells of COVID-19 patients in Japan","doi":"https://doi.org/10.1038/s41598-023-28696-9","datasets":["JGAD000665"]}],"datasets":["JGAD000665"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000665"]}]}