{"id":"hum0359","version":1,"url":"https://humandbs.dbcls.jp/research/hum0359/v1","datePublished":"2022-08-01","versions":[{"version":1,"datePublished":"2022-08-01"}],"title":{"ja":"T/NK細胞リンパ腫におけるゲノム・エピゲノム異常の解明","en":"Genomic and Epigenetic Analysis on T/NK-cell lymphoma"},"summary":{"aims":{"ja":"T/NK細胞リンパ腫の病態は不均一かつ複雑であり、比較的稀な疾患であることから、最適な治療が確立されていない。T/NK細胞リンパ腫に生じるゲノム異常、エピゲノム異常、遺伝子発現異常を包括的に解析することで、その病態を明らかにするだけでなく、特徴ある疾患単位、新たな分子標的、予後予測因子を同定できる可能性がある。本研究では、T/NK細胞リンパ腫のゲノム、エピゲノム、遺伝子発現を包括的に解析し、病理組織像、病型、予後などとの関連を検討することで、その分子病態を明らかにする。","en":"The pathogenesis of T/NK cell lymphoma is heterogeneous and complex, and optimal treatment has not been established, partly because the disease is relatively rare. Comprehensive analysis of genomic, epigenomic, and gene expression abnormalities occurring in T/NK cell lymphomas may not only clarify the pathogenesis of the disease, but also identify distinctive disease units, new molecular targets, and prognostic factors. In this study, we will comprehensively analyze the genome, epigenome, and gene expression of T/NK cell lymphoma, and clarify the molecular pathogenesis of the disease by examining the relationship with histopathology, disease type, and prognosis."},"methods":{"ja":"腫瘍（リンパ腫）組織のTargeted DNA sequencing解析","en":"Targeted DNA sequencing of tumor (lymphoma) tissues"},"targets":{"ja":"節外性NK/T細胞リンパ腫（鼻型）症例","en":"Extranodal NK/T-cell lymphoma, nasal type"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"節外性NK/T細胞リンパ腫（鼻型）：67症例\n（日本人）","en":"Extranodal NK/T-cell lymphoma, nasal type: 67 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Target Capture）","en":"NGS\n(Target Capture)"}},"releaseNote":{"ja":"節外性NK/T細胞リンパ腫（鼻型）症例の腫瘍組織より抽出したDNAを用いた29遺伝子のTarget Capture Sequencing解析データをbamファイルにて提供する。","en":"DNAs extracted from tumor tissues of patients with extranodal NK/T-cell lymphoma (nasal type) were used for the target capture sequencing analysis. Bam files are provided."},"dataProviders":[{"name":{"ja":"大石 直輝","en":"Naoki Oishi"},"organization":{"name":{"ja":"山梨大学 大学院総合研究部医学域人体病理学講座","en":"Department of Pathology, University of Yamanashi"}}}],"researchProjects":[],"grants":[{"title":{"ja":"節外性NK/T細胞リンパ腫の分子サブタイプに対応する病理組織学的所見の解明","en":"Histopathologic Features Associated with Molecular Subtypes of Extranodal NK/T Cell Lymphoma"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["21K06883"]},{"title":{"ja":"節外性NK/T細胞リンパ腫の予後を効率よく層別化できる病理学的スキームの開発","en":"Development of Molecular-based Pathologic Prognostic Stratification for Extranodal NK/T cell lymphoma, Nasal Type"},"agency":{"ja":"黒住医学研究振興財団・研究助成金","en":"Kurozumi Medical Foundation"},"grantIds":null}],"relatedPublications":[{"title":"Genetic and immunohistochemical profiling of NK/T-cell Lymphomas reveals prognostically relevant BCOR-MYC association","doi":"https://doi.org/10.1182/bloodadvances.2022007541","datasets":["JGAD000668"]}],"datasets":["JGAD000668"],"controlledAccessUsers":[]}