{"id":"hum0352","version":1,"url":"https://humandbs.dbcls.jp/research/hum0352/v1","datePublished":"2022-09-20","versions":[{"version":1,"datePublished":"2022-09-20"}],"title":{"ja":"肺癌放射線治療の治療効果および有害事象発症の予測に関与するタンパク機能、RNA発現の解析研究","en":"Analytical study of protein function and RNA expression involved in predicting treatment efficacy and adverse event development in lung cancer radiotherapy"},"summary":{"aims":{"ja":"肺がんへの放射線治療における治療効果および有害事象の発現に関与する、DNA修復タンパクの機能、RNA発現を明らかにすること。特に放射線治療による治療効果予測と、有害事象に関与している可能性が高いタンパク、およびその発現に関わるRNAを同定する。","en":"To elucidate the functions of DNA repair proteins and RNA expression that are involved in the therapeutic efficacy and adverse events of radiotherapy for lung cancer. In particular, this is an exploratory study to identify proteins and RNAs involved in the expression of proteins that are likely to be involved in the prediction of radiotherapy response and adverse events."},"methods":{"ja":"本研究について同意を得られた対象者の末梢血から抽出したRNAを用いたRNA-seq解析","en":"Peripheral blood samples were collected from the patients with lung cancer who gave consent for this study. RNA-sequencing analysis was performed with the RNAs extracted from the blood samples."},"targets":{"ja":"2019年から2020年にかけて当院にて放射線治療を行った原発性肺がん症例。その内、治療前後での治療効果判定および有害事象の評価が可能であり、放射線治療前、治療終了時、治療後2-4週間後の3点において採血可能な症例。","en":"Patients who have undergone radiotherapy for primary lung cancer at our hospital between 2019 and 2020 will be considered. Among them, we will include cases in which it is possible to determine the effect of treatment and evaluate adverse events before and, and whose blood can be drawn at 3 points: before radiotherapy, at the end of treatment, and 2-4 weeks after treatment."},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"原発性肺癌：5症例\n（日本人）","en":"primary lung cancer: 5 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"原発性肺がんに対し放射線治療を行った5症例15検体（放射線治療前、治療終了時、治療後2-4週間後の3点）の末梢血から抽出したRNAを用いたRNA-seq解析データをfastqファイルにて提供する。","en":"RNAs extracted from peripheral blood cells of primary lung cancer patients who have undergone radiotherapy were used for RNA-sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"染谷 正則","en":"Masanori Someya"},"organization":{"name":{"ja":"札幌医科大学医学部 放射線医学講座","en":"Department of Radiology, Sapporo Medical University, School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"リキッドバイオプシーを用いた個別化放射線治療の実践","en":"Practical application of individualized radiotherapy using liquid biopsy"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["21K07680"]}],"relatedPublications":[{"title":"Combined chemoradiotherapy and programmed cell death-ligand 1 blockade leads to changes in the circulating T-cell receptor repertoire of patients with non-small-cell lung cancer","doi":"https://doi.org/10.1111/cas.15566","datasets":["JGAD000664"]}],"datasets":["JGAD000664"],"controlledAccessUsers":[]}