{"id":"hum0348","version":1,"url":"https://humandbs.dbcls.jp/research/hum0348/v1","datePublished":"2023-05-15","versions":[{"version":1,"datePublished":"2023-05-15"}],"title":{"ja":"CD30陽性HTLV-1感染細胞のゲノム異常によるATL発症バイオマーカーの同定","en":"Analysis of ATL progression by CD30 signaling and its biomarkers"},"summary":{"aims":{"ja":"CD30陽性HTLV-1感染細胞の全ゲノムにわたる染色体構造とエキソーム領域の遺伝子配列を解析し、この細胞集団が高いゲノム不安定性を持つか、さらに、CD30リガンドを介したCD30刺激が染色体構造変異および遺伝子異常を促進するか評価することで、成人T細胞白血病（adult T-cell leukemia-lymphoma：ATL）の発症に関連するバイオマーカーの同定および病態進行のメカニズムの解明を目指す。","en":"To elucidate the mechanism of the tumorigenic process involving genomic aberrations by CD30 signaling in HTLV-1-infected T-cells"},"methods":{"ja":"FACS AriaIIIを用いてCD30発現ATL細胞、CD30非発現ATL細胞、HTLV-1非感染リンパ球を分画後、各分画からDNAを抽出し、whole exome sequencing解析を実施した。併せて、アレイCGH解析により網羅的なDNAコピー数の変化をプロファイリングした。","en":"CD30+ATL cells, CD30-ATL cells, and HTLV-1 uninfected lymphocytes were sorted by FACS AriaIII. DNA was extracted from each sorted cell and used for whole exome sequencing analysis and array-CGH analysis."},"targets":{"ja":"成人T細胞白血病（ATL）：8症例","en":"Adult T-cell leukemia/lymphoma (ATL): 8 cases"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"ATL：8症例\n（日本人）","en":"ATL: 8 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）\nアレイCGH","en":"NGS\n(Exome)\nArray CGH"}},"releaseNote":{"ja":"成人T細胞白血病（ATL）8症例のCD30発現ATL細胞、CD30非発現ATL細胞、HTLV-1非感染リンパ球の各分画から抽出したDNAを用いたwhole exome sequencing解析データをbamファイルにて提供する。\n成人T細胞白血病（ATL）8症例を対象としたアレイCGH解析データをtxtファイルにて提供する。","en":"DNAs extracted from CD30+ATL cells, CD30-ATL cells, and HTLV-1 uninfected lymphocytes from 8 patients with ATL were used for the whole exome sequencing analysis. Bam files are provided.\nDNAs extracted from 8 patients with ATL were used for the Array CGH analysis. Text files are provided."},"dataProviders":[{"name":{"ja":"中島 誠","en":"Makoto Nakashima"},"organization":{"name":{"ja":"東京大学大学院新領域創成科学研究科","en":"Graduate School of Frontier Sciences, The University of Tokyo"}}}],"researchProjects":[],"grants":[{"title":{"ja":"D30陽性HTLV-1感染細胞のゲノム異常によるATL発症バイオマーカーの同定","en":"Analysis of ATL progression by CD30 signaling and its biomarkers"},"agency":{"ja":"科学研究費助成事業 若手研究","en":"KAKENHI Grant-in-Aid for Early-Career Scientists"},"grantIds":["19K16580"]},{"title":{"ja":"CD30によるROS-DSBを介したゲノム不安定性とATL病態進展機構の解析","en":"The oncogenic driving force of CD30 signaling-induced chromosomal instability in adult T-cell leukemia/lymphoma"},"agency":{"ja":"科学研究費助成事業 若手研究","en":"KAKENHI Grant-in-Aid for Early-Career Scientists"},"grantIds":["22K15420"]}],"relatedPublications":[{"title":"The oncogenic driving force of CD30 signaling-induced chromosomal instability in adult T-cell leukemia/lymphoma","doi":"https://doi.org/10.1111/cas.15706","datasets":["JGAD000656"]}],"datasets":["JGAD000656"],"controlledAccessUsers":[]}