{"id":"hum0344","version":2,"url":"https://humandbs.dbcls.jp/research/hum0344/v2","datePublished":"2023-05-16","versions":[{"version":1,"datePublished":"2022-08-04"},{"version":2,"datePublished":"2023-05-16"}],"title":{"ja":"シークエンス解析によるがんゲノム研究：腎臓がん","en":"Genome sequencing analysis for biliary tract cancer"},"summary":{"aims":{"ja":"日本人の腎臓がんにおけるゲノム変異を探索する","en":"To investigate genomic alterations of Japanese biliary tract cancer"},"methods":{"ja":"全ゲノムシークエンス、トランスクリプトームシークエンス、ミトコンドリアDNAのアンプリコンシークエンス","en":"Whole genome sequencing analysis, transcriptome sequencing analysis, and amplicon sequencing analysis"},"targets":{"ja":"透析患者の腎臓がん、慢性腎臓病症例、および、HEK293細胞株","en":"Kidney cancer in endo-stage kidney disease, chronic kidney diseases, and HEK293 cell line"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現","en":"Sequencing, Expression profiling"},"targets":{"ja":"腎臓癌：38症例\n慢性腎臓病：77症例\n（日本人）\nHEK293細胞株：1検体\n（細胞株）","en":"kidney cancers: 38 cases\nchronic kidney disease: 77 cases\n(Japanese)\nHEK293 cell line: 1 sample\n(Cell-line)"},"typeOfData":{"ja":"NGS\n（WGS、RNA-seq、Amplicon-seq）","en":"NGS\n(WGS, RNA-seq, Amplicon-seq)"}},"releaseNote":{"ja":"CKDステージG1、G2、G4、G5の慢性腎臓病77症例の非腫瘍組織およびHEK293細胞株1検体から抽出したミトコンドリアDNAを用いたAmplicon-seq解析データをfastqファイルにて提供する。","en":"Mitochondrial DNAs extracted from non-tumor tissues from chronic kidney disease patients and HEK293 cell line were used for Amplicon-seq analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"中川 英刀","en":"Hidewaki Nakagawa"},"organization":{"name":{"ja":"理化学研究所 生命医科学研究センター がん免疫基盤研究部門 がんゲノム研究チーム","en":"Laboratory of Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences"}}}],"researchProjects":[{"name":{"ja":"理化学研究所がんゲノム研究チーム: https://www.riken.jp/research/labs/ims/genome_seq_anl/","en":"Laboratory for Cancer Genomics"},"url":{"ja":null,"en":[{"url":"https://www.riken.jp/en/research/labs/ims/genome_seq_anl/index.html","text":"https://www.riken.jp/en/research/labs/ims/genome_seq_anl/index.html"}]}},{"name":{"ja":"岩手医科大学泌尿器科: https://www.hosp.iwate-med.ac.jp/clinics/m19/","en":"Department of Urology, Iwate Medical University: https://www.hosp.iwate-med.ac.jp/clinics/m19/"},"url":{"ja":null,"en":null}}],"grants":[],"relatedPublications":[{"title":"Genomic features of renal cell carcinoma developed during end-stage renal disease and dialysis","doi":"https://doi.org/10.1093/hmg/ddac180","datasets":["JGAD000652"]},{"title":"Mitochondrial DNA Mutations at Low-level Heteroplasmy in Chronic Kidney Disease","doi":null,"datasets":["JGAD000740"]}],"datasets":["JGAD000652","JGAD000740"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"嘉島 相輝","en":"Soki Kashima"},"affiliation":{"ja":"大学院医学系研究科腎泌尿器科学講座, 秋田大学","en":"Urology, Akita University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"泌尿器癌(腎細胞癌、尿路上皮癌)における免疫療法の治療応答と有害事象の予測を目的とするバイオマーカーの探索研究","en":"A study to identify biomarkers for predicting treatment response and adverse events in immunotherapy for urological cancers (renal cell carcinoma and urothelial carcinoma)"},"periodStart":"2026-06-18","periodEnd":"2034-05-31","datasets":["JGAD000652"]}]}