{"id":"hum0343","version":1,"url":"https://humandbs.dbcls.jp/research/hum0343/v1","datePublished":"2022-05-26","versions":[{"version":1,"datePublished":"2022-05-26"},{"version":2,"datePublished":"2022-06-14"},{"version":3,"datePublished":"2024-06-21"},{"version":4,"datePublished":"2024-10-02"},{"version":5,"datePublished":"2026-08-13"}],"title":{"ja":"新型コロナウイルス感染症の遺伝学的知見に基づいたCOVID19ワクチンの開発と評価系の構築","en":"Development of COVID19 vaccine and evaluation system based on genetics of COVID-19"},"summary":{"aims":{"ja":"新型コロナウイルス感染症患者、無症候性感染者及び新型コロナウイルス感染症が疑われる患者の全ゲノムシーケンス、RNAシーケンス、超高精度HLA解析などを通して、重症化予測法システムの構築を行うことを目的とする。また、匿名化データを使用しCOVID-19の重症度予測などを数理モデルで解析する。","en":"To construct a prediction system for severe disease through whole genome sequencing, RNA sequencing, and ultra-high-precision HLA analysis of patients with COVID-19, asymptomatic infected patients, and patients suspected of having novel coronavirus infection. In addition, we will use anonymized data to analyze the prediction of severity of COVID-19 using mathematical models."},"methods":{"ja":"ゲノムワイド関連解析、RNA-seq","en":"Genome-wide association study (GWAS), RNA-seq"},"targets":{"ja":"ゲノムワイド関連解析：日本人5682名 （COVID-19感染症患者：2393名、対照者：3289名）\nRNA-seq：日本人COVID-19感染症患者473名","en":"GWAS: 5682 Japanese individuals (2393 COVID-19 infected patients and 3289 controls)\nRNA-seq: 473 COVID-19 infected patients"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"COVID19感染者2,393名および対照者3,289名の末梢血から抽出したDNAを用いたSNPアレイデータによるGenotypingデータのGWAS統計データ、並びに、473症例の末梢血から抽出したRNAを用いたRNA-seq解析データのリードカウントデータをテキスト形式にて提供する。","en":"GWAS\nDNAs extracted from peripheral blood cells of 2393 COVID-19 infected patients and 3289 controls were genotyped by using of Illumina Infinium Asian Screening Array and genome-wide association studies were performed (txt files).\nRNA-seq\nRNAs extracted from peripheral blood cells of 473 COVID-19 infected patients were used for RNA sequencing analysis. The read count data (text file) is provided."},"dataProviders":[{"name":{"ja":"福永 興壱","en":"Koichi Fukunaga"},"organization":{"name":{"ja":"慶應義塾大学医学部 呼吸器内科","en":"Department of Medicine, Pulmonary Division, Keio University School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"新型コロナウイルス感染症の遺伝学的知見に基づいた分子ニードルCOVID-19粘膜免疫ワクチンの開発","en":"Development of genetically-designed COVID19 mucosal immune vaccine with molecular needle platform"},"agency":{"ja":"国立研究開発法人日本医療研究開発機構（AMED）創薬支援推進事業","en":"Project Promoting Support for Drug Discovery, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP20nk0101612"]},{"title":{"ja":"新型コロナウイルス感染症の重症化阻止を目指した医薬品・次世代型ワクチン開発に必要な遺伝学・免疫学・代謝学的基盤研究の推進","en":"Promotion of genetic, immunological, and metabolic research necessary for the development of next-generation vaccines and drugs aiming to prevent the aggravation of coronavirus disease 2019"},"agency":{"ja":"新興・再興感染症に対する革新的医薬品等開発推進研究事業","en":"Research Program on Emerging and Re-emerging Infectious Diseases, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP20fk0108415"]},{"title":{"ja":"新型コロナ変異ウイルスに対する遺伝学的、免疫学的、代謝学的病態解明および治療戦略の策定","en":"Elucidation of pathogenesis and development of therapeutic strategies using genetic, immunological, and metabolic studies against SARS-CoV-2 variants"},"agency":{"ja":"新興・再興感染症に対する革新的医薬品等開発推進研究事業","en":"Research Program on Emerging and Re-emerging Infectious Diseases, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP20fk0108452"]},{"title":{"ja":"新型コロナウイルス感染症後遺症の病態生理の多分野融合による解明","en":"Elucidation of the pathophysiology of the sequelae of coronavirus disease 2019 using a multidisciplinary approach"},"agency":{"ja":"新興・再興感染症研究基盤創生事業（多分野融合研究領域）","en":"Japan Program for Infectious Diseases Research and Infrastructure, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP21wm0325031"]},{"title":{"ja":"先端ゲノム解析と人工知能によるコロナ制圧研究","en":"Research on Conquering Coronavirus Disease by Advanced Genomic Analysis and Artificial Intelligence"},"agency":{"ja":"国立研究開発法人科学技術振興機構（JST） 戦略的創造研究推進事業CREST","en":"Core Research and Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST)"},"grantIds":["JPMJCR20H2"]},{"title":{"ja":"免疫オミクス情報の横断的統合による関節リウマチのゲノム個別化医療の実現","en":"Genomic prediction medicine of rheumatoid arthritis based on comprehensive immune-omics resources"},"agency":{"ja":"国立研究開発法人日本医療研究開発機構（AMED） 免疫アレルギー疾患実用化研究事業","en":"Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP20ek0410075"]},{"title":{"ja":"横断的オミクス解析と全ゲノムシークエンスを駆使した疾患病態と組織特異性 の解明","en":"Elucidation of tissue-specificity of disease biology using trans-layer omics analysis and whole-genome sequencing"},"agency":{"ja":"科学研究費補助金 基盤研究（A）","en":"KAKENHI Grant-in-Aid for Scientific Research (A)"},"grantIds":["19H01021"]}],"relatedPublications":[],"datasets":["NHA000169","NHA000168"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000874"]}]}