{"id":"hum0338","version":1,"url":"https://humandbs.dbcls.jp/research/hum0338/v1","datePublished":"2022-11-22","versions":[{"version":1,"datePublished":"2022-11-22"}],"title":{"ja":"加齢またはピロリ感染の影響がない胃がんに対する包括的がんゲノム・エピゲノム・免疫ゲノム解析","en":"Comprehensive cancer genome, epigenome, and immunogenome analysis for gastric cancer unaffected by aging or Helicobacter pylori infection"},"summary":{"aims":{"ja":"2014年がんゲノムアトラス（The Cancer Genome Atlas：TCGA）を皮切りに、アジアがん研究グループ（Asian Cancer Research Group：ACRG）や東アジアの研究グループより全ゲノムシーケンスを含む複数の進行胃がんに関する報告があり、網羅的・包括的なゲノム解析データが集積・公開され、利用可能な状態になっている。ピロリ菌感染と付随する炎症は加齢と並んで胃がんの重要なリスク因子であり、ほとんどの胃がん患者でピロリ感染の痕跡が見られる。しかし、若年性でピロリ陰性の胃がんも少数存在し、そのような患者のゲノムプロファイルの詳細は不明である。本研究は、加齢やピロリ感染といった通常の胃がんの発がんに強く関与する因子を持たない患者集団に絞り、新たな発がん及びがんの進展の本質をなす分子異常の解明と新規治療標的の探索を行うことを目的とする。さらに、治療標的候補が同定された際には、in vitro, vivoで機能解析や生物学的意義を検証する。","en":"Comprehensive genome data for advanced gastric cancer have already been accumulated, widely published, and available including the Cancer Genome Atlas (TCGA) published in 2014 and the Asian Cancer Research Group (ACRG) in 2015. Aging and inflammation associated with H. pylori (HP) is an important risk factor for gastric cancer. HP shows evidence of infection in most gastric cancer patients. However, there are also a small number of juvenile and HP-negative gastric cancers, and the details of their genomic profile are unknown. This study narrows down to a patient population without factors such as aging and HP infection to elucidate the molecular abnormalities essential to new carcinogenesis and cancer progression, search for new therapeutic targets and to analyze the function of them to verify their biological significance in vitro and in vivo."},"methods":{"ja":"Whole Exome Sequencing解析","en":"Whole Exome Sequencing Analysis"},"targets":{"ja":"ピロリ菌未感染胃がん：27症例、ピロリ菌感染胃がん：36症例","en":"H. Pylori uninfected gastric cancer: 27 patients, H. Pylori infected gastric cancer: 36 patients"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"ピロリ菌未感染胃癌：27症例\nピロリ菌感染胃癌：36症例\n（日本人）","en":"H. Pylori uninfected gastric cancer: 27 cases\nH. Pylori infected gastric cancer: 36 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"ピロリ菌未感染胃がん27症例、および、ピロリ菌感染胃がん36症例の腫瘍組織および非腫瘍組織から抽出したDNAを用いたwhole exome sequencing解析データをfastqファイルにて提供する。","en":"DNAs extracted from tumor and non-tumor tissues of H. Pylori uninfected gastric cancer patients and H. Pylori infected gastric cancer patients were used for the whole exome sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"森 誠一","en":"Seiichi Mori"},"organization":{"name":{"ja":"がん研究会 がんプレシジョン医療研究センター 次世代がん研究シーズ育成プロジェクト","en":"Cancer Precision Medicine Center, Japanese Foundation for Cancer Research"}}}],"researchProjects":[],"grants":[{"title":{"ja":null,"en":null},"agency":{"ja":"武田薬品ジャパンメディカルオフィス研究助成金","en":"Takeda Japan Medical Office Funded Research Grant"},"grantIds":null}],"relatedPublications":[{"title":"Genomic features of Helicobacter pylori-naïve diffuse-type gastric cancer","doi":"https://doi.org/10.1002/path.6000","datasets":["JGAD000701"]}],"datasets":["JGAD000701"],"controlledAccessUsers":[]}