{"id":"hum0332","version":1,"url":"https://humandbs.dbcls.jp/research/hum0332/v1","datePublished":"2022-05-30","versions":[{"version":1,"datePublished":"2022-05-30"}],"title":{"ja":"遺伝子マーカーを用いた尿路性器癌の個別化治療法に関する研究","en":"A study on personalized medicine in genitourinary cancers using genetic biomarkers."},"summary":{"aims":{"ja":"尿路性器がんの治療効果予測バイオマーカーの探索","en":"To detect predictive biomarkers for genitourinary cancer treatment."},"methods":{"ja":"Whole Exome Sequencing解析（WES）","en":"Whole exome sequencing analysis"},"targets":{"ja":"去勢抵抗性前立腺がん（castration-resistant prostate cancer: CRPC）症例から採取した腫瘍組織ならびに末梢血白血球","en":"Genomic DNAs extracted from tumor tissues and leukocytes that were obtained from one castration-resistant prostate cancer (CRPC) patient."},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"去勢抵抗性前立腺癌：1症例\n（日本人）","en":"1 castration-resistant prostate cancer\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"去勢抵抗性前立腺がん1症例の腫瘍組織、並びに、末梢血白血球から抽出したDNAを用いたWES解析データを提供する（fastq）。","en":"Genomic DNAs extracted from tumor tissues and leukocytes that were obtained from one castration-resistant prostate cancer (CRPC) patient were used for WES analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"赤松 秀輔","en":"Shusuke Akamatsu"},"organization":{"name":{"ja":"京都大学大学院医学研究科 泌尿器科学","en":"Kyoto University Graduate School of Medicine Department of Urology"}}}],"researchProjects":[],"grants":[{"title":{"ja":"血中遊離DNA解析を応用した前立腺癌のDNA修復遺伝子異常の生物学的特性の解明","en":"Understanding the biological mechanisms of defective DNA damage repair in prostate cancer using cell-free DNA analysis"},"agency":{"ja":"日本学術振興会科学研究費補助金","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["20H03814"]}],"relatedPublications":[{"title":"A case of microsatellite instability-high clinically advanced castration-resistant prostate cancer showing a remarkable response to pembrolizumab sustained over at least 18 months","doi":"https://doi.org/10.1101/mcs.a006194","datasets":["JGAD000628"]}],"datasets":["JGAD000628"],"controlledAccessUsers":[]}