{"id":"hum0316","version":1,"url":"https://humandbs.dbcls.jp/research/hum0316/v1","datePublished":"2022-05-26","versions":[{"version":1,"datePublished":"2022-05-26"}],"title":{"ja":"食道がんの全ゲノムシークエンス解析による病態解明と治療感受性マーカーの探索に関する研究","en":"Whole-genome sequencing of esophageal cancer to elucidate pathogenesis and search for treatment-sensitive markers"},"summary":{"aims":{"ja":"日本人の食道扁平上皮がんにおけるゲノム変異を探索する","en":"Search for genomic mutations in esophageal squamous cell carcinoma in Japanese."},"methods":{"ja":"食道扁平上皮がん切除切片における非腫瘍組織（正常組織）および腫瘍組織より抽出したDNAを用いたWhole Genome Sequencing解析、ならびに、腫瘍組織より抽出したRNAを用いたRNA-seq解析。","en":"NGS libraries using DNA extracted from non-tumor tissues (normal tissues) and tumor tissues and NGS libraries using RNA extracted from tumor tissues in resected sections of esophageal squamous cell carcinoma are prepared and sequenced using Illumina HiSeq 2000/2500."},"targets":{"ja":"食道扁平上皮がん症例の腫瘍組織および非腫瘍組織","en":"tumor tissues and non-tumor tissues of esophageal squamous cell carcinoma cases"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現","en":"Sequencing, Expression profiling"},"targets":{"ja":"食道扁平上皮癌：110症例\n（日本人）","en":"Esophageal squamous cell carcinoma: 110 cases"},"typeOfData":{"ja":"NGS\n（WGS、RNA-seq）","en":"NGS\n(WGS, RNA-seq)"}},"releaseNote":{"ja":"食道扁平上皮がん症例の腫瘍組織および非腫瘍組織より抽出したDNAを用いたWGS解析データ、ならびに、腫瘍組織より抽出したRNAを用いたRNA-seq解析データをFastqファイルにて提供する。","en":"DNAs and RNAs extracted from tumor tissues and non-tumor tissue (normal tissue) in resected sections of esophageal squamous cell carcinoma patients were used for WGS and RNA-seq analyses. Fastq files are provided."},"dataProviders":[{"name":{"ja":"中川 英刀","en":"Hidewaki Nakagawa"},"organization":{"name":{"ja":"理化学研究所 生命医科学研究センター がんゲノム研究チーム","en":"RIKEN Center for Integrative Medical Sciences Laboratory of Genome Sequencing Analysis"}}}],"researchProjects":[],"grants":[{"title":{"ja":"がんゲノム解析による新規免疫療法および複合免疫療法開発のためのシーズ探索","en":"Search for seeds for the development of novel immunotherapies and combined immunotherapies by cancer genome analysis"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん医療創生研究事業（P-CREATE）","en":"Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP20cm0106552"]}],"relatedPublications":[{"title":"Immuno-genomic Profiling of Biopsy Specimens Predicts Neoadjuvant Chemotherapy Response in Esophageal Squamous Cell Carcinoma","doi":"https://doi.org/10.1016/j.xcrm.2022.100705","datasets":["JGAD000654"]}],"datasets":["JGAD000654"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000654"]},{"principalInvestigator":{"ja":"杉田 静紀","en":"Shizuki Sugita"},"affiliation":{"ja":"腫瘍外科, 名古屋大学大学院医学系研究科","en":"Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"全ゲノム解析による食道癌の周術期補助療法と早期再発に関する研究","en":"Elucidation of the impact of neoadjuvant therapy on tumor microenvironment and the factor of early recurrence in esophageal cancer patients by whole genome sequencing"},"periodStart":"2023-04-07","periodEnd":"2023-12-07","datasets":["JGAD000654"]}]}