{"id":"hum0307","version":1,"url":"https://humandbs.dbcls.jp/research/hum0307/v1","datePublished":"2022-03-11","versions":[{"version":1,"datePublished":"2022-03-11"}],"title":{"ja":"アトピー性皮膚炎患者における皮膚成分の解析（2）","en":"Analysis for skin molecules in patients with atopic dermatitis No.2."},"summary":{"aims":{"ja":"試験1「健常者における皮膚物性および皮膚成分の解析」および試験2「アトピー性皮膚炎患者における皮膚成分の解析」において実施したRNA発現量を解析し、健常者とAD患者間の皮脂RNAの違いを解明すること。","en":"Evaluate the differences of sebum RNA between healthy males and male patients with atopic dermatitis using the data of study 1 (Analysis for skin molecules and properties in healthy subjects) and study 2 (Analysis for skin molecules in patients with atopic dermatitis)."},"methods":{"ja":"皮脂中のRNA発現量のAmpliSeq Transcriptomeを用いたRNA-seq解析","en":"AmpliSeq Transcriptome analysis was performed to analyze human mRNA expressions in sebum RNA"},"targets":{"ja":"健常男性29名、および、アトピー性皮膚炎男性患者30症例","en":"Healthy males: 29, Male patients with atopic dermatitis: 30"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"健常男性：29名\n男性のアトピー性皮膚炎：30症例\n（日本人）","en":"29 healthy male subjects\natopic dermatitis: 30 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"健常男性29名およびアトピー性皮膚炎男性患者30名の顔面皮脂から抽出したRNAを用いたRNA-seq解析データをbamファイルにて提供する。","en":"RNAs extracted from sebum of 29 healthy males and 30 male patients with atopic dermatitis were used for RNA-sequencing analysis. Bam files are provided."},"dataProviders":[{"name":{"ja":"井上 高良","en":"Takayoshi Inoue"},"organization":{"name":{"ja":"花王株式会社 生物科学研究所","en":"Biological Science Laboratories, Kao Corporation"}}}],"researchProjects":[{"name":{"ja":"皮脂RNAプロジェクト","en":"Sebum RNA project"},"url":{"ja":null,"en":null}}],"grants":[],"relatedPublications":[{"title":"Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids","doi":"https://doi.org/10.1038/s42003-022-03154-w","datasets":["JGAD000533"]}],"datasets":["JGAD000533"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000533"]}]}