{"id":"hum0300","version":1,"url":"https://humandbs.dbcls.jp/research/hum0300/v1","datePublished":"2021-11-12","versions":[{"version":1,"datePublished":"2021-11-12"}],"title":{"ja":"がんの全ゲノム・全エキソンシークエンス解析","en":"Whole-genome and whole-exome analyses of cancer"},"summary":{"aims":{"ja":"次世代シーケンサーを始めとする種々のゲノム解析手法により同定されるゲノム・エピゲノム異常やCopy number variant（CNV）の異常、遺伝子発現異常などを併せた統合的Omics解析によって、がんの原因遺伝子や主要シグナル伝達経路を明らかにし、がん病態を包括的に理解するとともに画期的ながん分子診断法の開発ならびに治療標的分子の同定を行うこと。","en":"We perform integrative genome-wide analyses such as whole-exome sequencing, epigenome analysis, copy number variant (CNV) analysis, and gene expression analysis using next-generation sequencing and other methods to elucidate driver genes and signaling pathways causing tumorigenesis and cancer progression, leading novel molecular diagnostics and molecular therapies."},"methods":{"ja":"全エクソンシーケンスおよびRNA-seq","en":"Whole-exome sequencing, RNA-sequencing"},"targets":{"ja":"全エクソン解析：食道扁平上皮がん88症例、RNA-seq解析：食道扁平上皮がん57症例（56症例に対して両解析を実施）","en":"Whole-exome sequencing, Esophageal squamous cell carcinoma, tumor and paired non-tumor, 88 pairs; RNA-sequencing, Esophageal squamous cell carcinoma, tumor and paired non-tumor, 57 pairs"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現","en":"Sequencing, Expression profiling"},"targets":{"ja":"食道扁平上皮癌：89症例\n（日本人）","en":"89 Esophageal squamous cell carcinomas\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome、RNA-seq）","en":"NGS\n(Exome, RNA-seq)"}},"releaseNote":{"ja":"食道扁平上皮がんの腫瘍組織および非腫瘍組織から抽出したDNA/RNAを用いたExome、RNA-seq解析の結果をfastqファイル形式で提供する。","en":"DNAs/RNAs extracted from tumor and paired non-tumor tissues of esophageal squamous cell carcinoma patients were used for the whole exome sequencing and RNA sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"稲澤 譲治","en":"Johji Inazawa"},"organization":{"name":{"ja":"東京医科歯科大学 難治疾患研究所 分子細胞遺伝","en":"Department of molecular cytogenetics, Medical Research Institute, Tokyo Medical and Dental University"}}}],"researchProjects":[],"grants":[{"title":{"ja":"がん細胞文脈のシステム的統合理解による新たながん診断・治療概念の確立","en":"Establishment of novel concept for cancer diagnostics and therapeutics based on the systematic comprehension of cellular context in cancer"},"agency":{"ja":"科学研究費助成事業 新学術領域研究（研究領域提案型）","en":"KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)"},"grantIds":["15H05908"]},{"title":{"ja":"食道扁平上皮がんの新規治療標的分子と診断バイオマーカーの同定","en":"Identification of novel therapeutic target molecules and diagnostic biomarkers for esophageal squamous cell carcinoma"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん研究シーズ戦略的育成プログラム（P-DIRECT）","en":"Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP15cm0106067"]},{"title":{"ja":"ゲノム網羅的解析情報を基盤とするオーダーメイドがん医療実現のための開発研究","en":"Research and development for tailor-made cancer treatment based on integrative genome analyses"},"agency":{"ja":"日本医療研究開発機構（AMED） オーダーメイド医療の実現プログラム","en":"Tailor-Made Medical Treatment with the BioBank Japan Project (BBJ), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP17km0506001"]},{"title":{"ja":null,"en":null},"agency":{"ja":"東京医科歯科大学 難治疾患共同研究拠点","en":"Tokyo Medical and Dental University, Nanken-Kyoten"},"grantIds":null}],"relatedPublications":[{"title":"Integrative genome-wide analyses reveal the transcriptional aberrations in Japanese esophageal squamous cell carcinoma","doi":"https://doi.org/10.1111/cas.15063","datasets":["JGAD000481"]}],"datasets":["JGAD000481"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000481"]},{"principalInvestigator":{"ja":"藤井 誠志","en":"Satoshi Fujii"},"affiliation":{"ja":"分子病理学, 横浜市立大学","en":"Molecular pathology, Yokohama City University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"多臓器に跨る扁平上皮癌におけるPD L1 免疫組織化学染色の精度管理と染色態度の生物学的意義の解明に関する観察研究","en":"A observational study to control the accuracy of PD-L1 immunohistochemistry and to elucidate the biological significance of the staining affinity in squamous cell carcinoma across multiple organs"},"periodStart":"2025-10-07","periodEnd":"2026-07-23","datasets":["JGAD000481"]}]}