{"id":"hum0299","version":1,"url":"https://humandbs.dbcls.jp/research/hum0299/v1","datePublished":"2022-09-15","versions":[{"version":1,"datePublished":"2022-09-15"}],"title":{"ja":"ロングリードシークエンサーを用いたがん突然変異の染色体背景の解析","en":"Analysis of chromosome background of cancerous mutations using a long read sequencer"},"summary":{"aims":{"ja":"ナノポアシークエンサーPromethIONの新たなプラットフォームQ20を用いた全ゲノムシークエンスによるハプロタイプフェージング解析の精度への影響を調べる","en":"Whole genome sequencing using the newly available PromethION Q20 platform (Nanopore) to validate haplotype phasing analysis"},"methods":{"ja":"ナノポアシークエンサーPromethIONの新たなプラットフォームQ20を用いた全ゲノムシークエンス","en":"Whole genome sequencing using the PromethION Q20 platform (Nanopore)"},"targets":{"ja":"健常白人由来B細胞株HG002（NA24385）","en":"Healthy white B-Lymphocyte cell line HG002 (NA24385)"},"url":{"ja":[{"url":"https://www.k.u-tokyo.ac.jp/information/category/press/9567.html","text":"https://www.k.u-tokyo.ac.jp/information/category/press/9567.html"}],"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"健常白人由来B細胞株HG002（NA24385）：1検体\n（細胞株）","en":"Healthy white B-Lymphocyte cell line HG002 (NA24385): 1 sample\n(Cell-line)"},"typeOfData":{"ja":"NGS\n（WGS）","en":"NGS\n(WGS)"}},"releaseNote":{"ja":"健常白人由来B細胞株HG002（NA24385）より抽出したDNAを対象とし、ナノポアシークエンサーPromethIONの新たなプラットフォームQ20を用いた全ゲノムシークエンス解析データをfastqファイルにて提供する。","en":"DNA extracted from Healthy white B-Lymphocyte cell line HG002 (NA24385) was used for whole-genome sequencing analysis by using of Q20 platform (PromethION, Nanopore). Fastq files are provided."},"dataProviders":[{"name":{"ja":"鈴木 穣","en":"Yutaka Suzuki"},"organization":{"name":{"ja":"東京大学大学院 新領域創成科学研究科 メディカル情報生命専攻 生命システム観測分野","en":"Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo"}}}],"researchProjects":[],"grants":[{"title":{"ja":"上皮内肺がん等の全ゲノムシークエンス解析による新規ドライバー遺伝子の同定","en":"Identification of novel driver genes by whole genome sequencing of early stage lung tumors"},"agency":{"ja":"科学研究費助成事業 新学術領域研究","en":"KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas"},"grantIds":["20H00545"]},{"title":{"ja":"ロングリードによる肺がんゲノム構造変異とDNAメチル化状態の統合解明","en":"Integrative analysis of structural variants and DNA methylation statuses in lung cancer genomes using long read sequencing"},"agency":{"ja":"科学研究費助成事業 新学術領域研究","en":"KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas"},"grantIds":["21J13203"]},{"title":{"ja":"先進ゲノム解析研究推進プラットフォーム","en":"Platform for Advanced Genome Science"},"agency":{"ja":"科学研究費助成事業 新学術領域研究","en":"KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas"},"grantIds":["16H06279"]},{"title":{"ja":"ロングリード技術を駆使した非小細胞肺癌におけるがんゲノム多様性・進化に関する研究","en":"Stratification of cancer patients by novel genomic aberrations using long-read sequencing technologies"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん医療創生研究事業（P-CREATE）","en":"Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP21cm0106582"]},{"title":{"ja":"受動喫煙により惹起される肺がんゲノム変異の多様性の理解と治療方針の策定","en":"Understanding the diversity of lung cancer genomic mutations induced by passive smoking and formulating therapeutic strategies"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん医療創生研究事業（P-CREATE）","en":"Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP21cm0106577"]}],"relatedPublications":[{"title":"Phasing analysis of lung cancer genomes using a long read sequencer","doi":"https://doi.org/10.1038/s41467-022-31133-6","datasets":["DRA012759"]}],"datasets":["DRA012759"],"controlledAccessUsers":[]}