{"id":"hum0296","version":1,"url":"https://humandbs.dbcls.jp/research/hum0296/v1","datePublished":"2021-10-19","versions":[{"version":1,"datePublished":"2021-10-19"}],"title":{"ja":"十二指腸腺腫の進展に関連する遺伝子変化の同定と、内視鏡による癌への進展予測への応用","en":"Detection of genetic changes associated with development of duodenal adenoma and their application for predicting the progression to cancer by endoscopy"},"summary":{"aims":{"ja":"十二指腸腺腫、腺腫内癌、十二指腸進行癌の遺伝子変化（メチル化、変異）を解析することにより、ポリープの段階で癌への進展が予測できる遺伝子変化を同定すること。","en":"The aim of this study is to analyze the methylation and mutation status of non-ampullary duodenal lesions in order to detect the genetic changes for predicting the progression to adenocarcinomas."},"methods":{"ja":"エキソームシーケンスによって、十二指腸発癌におけるドライバー遺伝子変異・コピー数変化・融合遺伝子の同定を行う。","en":"Exome sequencing was performed to detect driver gene mutations, copy number alterations, and fusion genes in non-ampullary duodenal carcinogenesis."},"targets":{"ja":"十二指腸腺腫の3症例を対象とし、病変部3サンプルと正常粘膜3サンプルの生検組織由来のDNAの解析を行なった。","en":"We used DNA samples of three non-ampullary duodenal adenomas and three adjacent normal mucosa from three Japanese patients with non-ampullary duodenal adenoma."},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"十二指腸腺腫患者：3名 （日本人）","en":"3 patients with non-ampullary duodenal adenoma (Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"十二指腸腺腫患者の腫瘍組織および非腫瘍組織から抽出したDNAを用いたエキソームシークエンス解析の結果をfastqファイルにて提供する。","en":"DNAs extracted from tumor and non-tumor tissues collected from 3 patiets with non-ampullary duodenal adenoma were used for Exome sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"澤田 武","en":"Takeshi Sawada"},"organization":{"name":{"ja":"金沢大学がん進展制御研究所 腫瘍制御研究分野","en":"Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University"}}}],"researchProjects":[],"grants":[{"title":{"ja":"先進ゲノム解析研究推進プラットフォーム","en":"Platform for Advanced Genome Science"},"agency":{"ja":"科学研究費助成事業 新学術領域研究","en":"KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas"},"grantIds":["16H06279"]}],"relatedPublications":[],"datasets":["JGAD000466"],"controlledAccessUsers":[]}