{"id":"hum0293","version":1,"url":"https://humandbs.dbcls.jp/research/hum0293/v1","datePublished":"2022-07-25","versions":[{"version":1,"datePublished":"2022-07-25"}],"title":{"ja":"造血器腫瘍・難治性腫瘍の治療感受性を規定する遺伝学的宿主側因子、腫瘍側因子の探索研究","en":"Exploratory research of genetic factors that regulate the therapeutic sensitivity of hematopoietic malignancy"},"summary":{"aims":{"ja":"造血器腫瘍の分子病態・治療感受性を規定する遺伝学的因子の探索","en":"Exploration of genetic factors that contribute to molecular pathogenesis and therapeutic sensitivity of hematopoietic malignancies"},"methods":{"ja":"1. 成人T細胞性白血病リンパ腫（adult T-cell leukemia/lymphoma：ATL）症例の末梢血より腫瘍細胞を含む単核球を分離後、抽出したDNAを用いたwhole genome sequencing解析\n2. ATL細胞株（TL-om1細胞）に対して遺伝子改変操作を行った後、抽出したDNAを用いたwhole genome sequencing解析","en":"1. Genomic DNA was extracted from peripheral blood mononuclear cells of primary adult T-cell leukemia/lymphoma (ATL) patients. Library construction and whole-genome sequencing analysis were performed.\n2. After genetic modifications in the ATL Cell line (TL-om1 cell), genomic DNA was extracted from the cells. Library construction and whole-genome sequencing analysis were performed."},"targets":{"ja":"ATL症例、ならびに、遺伝子改変操作を行ったATL細胞株","en":"ATL patients and ATL cell line"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"成人T細胞性白血病リンパ腫（ATL）：7症例\nATL細胞株（TL-om1）：1検体\n（日本人）","en":"ATL: 7 cases\nATL cell line: 1 sample\n(Japanese)"},"typeOfData":{"ja":"NGS\n（WGS）","en":"NGS\n(WGS)"}},"releaseNote":{"ja":"成人T細胞性白血病リンパ腫7症例の末梢血単核球より抽出したDNAを用いたWGS解析データ、ならびに、12の実験条件（遺伝子改変操作）を行ったATL細胞株（TL-om1）より抽出したDNAを用いたWGS解析データをfastqファイルにて提供する。","en":"DNAs extracted from peripheral blood mononuclear cells of primary ATL patients or an ATL cell line with 12 genetic modifications were used for whole genome sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"三田 貴臣","en":"Takaomi Sanda"},"organization":{"name":{"ja":"名古屋市立大学医学部 血液腫瘍内科学/シンガポール国立大学 癌科学研究所","en":"Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences / Cancer Science Institute of Singapore, National University of Singapore"}}}],"researchProjects":[],"grants":[{"title":{"ja":"エンハンサープロファイリングによる造血器腫瘍の分子病態理解と治療法の開発","en":"Understanding of molecular pathogenesis and development of therapeutics by enhancer profiling"},"agency":{"ja":"科学研究費助成事業 国際共同研究加速基金（帰国発展研究）","en":"KAKENHI Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)"},"grantIds":["18K19960"]}],"relatedPublications":[],"datasets":["JGAD000431"],"controlledAccessUsers":[]}