{"id":"hum0286","version":2,"url":"https://humandbs.dbcls.jp/research/hum0286/v2","datePublished":"2022-11-15","versions":[{"version":1,"datePublished":"2022-09-12"},{"version":2,"datePublished":"2022-11-15"}],"title":{"ja":"非アルコール性脂肪性肝疾患患者における肝癌発症・進展機序の解明","en":"Elucidation of molecular mechanism of NAFLD-HCC"},"summary":{"aims":{"ja":"非ウイルス性肝細胞がんの腫瘍免疫微小環境におけるがん細胞と免疫細胞の相互作用を解明すること","en":"To elucidate the interaction between cancer cells and immune cells in the tumor immune microenvironment of non-viral hepatocellular carcinoma"},"methods":{"ja":"Visium空間的遺伝子発現解析、Target Capture Sequencing解析","en":"Visium Spatial Gene Expression Assay, Target Capture Sequencing Analysis"},"targets":{"ja":"Visium空間的遺伝子発現解析：脂肪を含む肝細胞がん（hepatocellular carcinoma：HCC）検体#1、脂肪を含むHCCの非腫瘍組織#2、脂肪を含むHCCの腫瘍検体#3、脂肪を含まないHCCの腫瘍組織#4。＃1と＃2は同一症例由来の検体。\nTarget Capture Sequencing解析：肝細胞がん55症例","en":"Visium Spatial Gene Expression Assay: Four samples containing a fat-containing hepatocellular carcinoma (HCC) tissue#1, a non-tumor tissue of fat-containing HCC tissue#2, a fat-containing HCC tissue#3, and a fat-not containing HCC tissue#4. #1 and #2 are tissues derived from the same patient.\nTarget Capture Sequencing Analysis: Tumor tissues and non-tumor tissues of 55 hepatocellular carcinoma patients"},"url":{"ja":[{"url":"https://www.med.osaka-u.ac.jp/activities/results/2022year/takehara2022-5-16","text":"https://www.med.osaka-u.ac.jp/activities/results/2022year/takehara2022-5-16"}],"en":[{"url":"https://www.med.osaka-u.ac.jp/eng/activities/results/2022year/takehara2022-5-16","text":"https://www.med.osaka-u.ac.jp/eng/activities/results/2022year/takehara2022-5-16"}]}},"listingSummary":{"methods":{"ja":"発現\n病理画像\n配列決定","en":"Expression profiling, Histological imaging, Sequencing"},"targets":{"ja":"肝細胞癌：55症例\n（日本人）","en":"55 hepatocellular carcinoma\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Visium Spatial Gene Expression、Target Capture）\n病理画像","en":"NGS\n(Visium Spatial Gene Expression, Target Capture)\nHistological image"}},"releaseNote":{"ja":"肝細胞がん55症例の腫瘍組織ならびに非腫瘍組織より抽出したDNAを用いたTERT遺伝子プロモータ領域＋69遺伝子のエクソン領域を対象としたTarget Capture Sequencing解析の結果をbamファイルにて提供する。","en":"DNAs extracted from tumor tissues and non-tumor tissues of hepatocellular carcinoma patients were used for a target capture sequencing analysis. Bam files are provided."},"dataProviders":[{"name":{"ja":"小玉 尚宏","en":"Takahiro Kodama"},"organization":{"name":{"ja":"大阪大学大学院医学系研究科消化器内科学教室","en":"Dept. Gastroenterology and Hepatology, Graduate School of Medicine, Osaka University"}}}],"researchProjects":[],"grants":[{"title":{"ja":"先進ゲノム解析研究推進プラットフォーム","en":"Platform for Advanced Genome Science"},"agency":{"ja":"科学研究費助成事業 新学術領域研究","en":"KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas"},"grantIds":["16H06279"]}],"relatedPublications":[{"title":"Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma","doi":"https://doi.org/10.1002/hep.32573","datasets":["JGAD000422","JGAD000642"]}],"datasets":["JGAD000422","JGAD000642"],"controlledAccessUsers":[]}