{"id":"hum0275","version":1,"url":"https://humandbs.dbcls.jp/research/hum0275/v1","datePublished":"2021-08-16","versions":[{"version":1,"datePublished":"2021-08-16"}],"title":{"ja":"固形腫瘍における遺伝子異常の網羅的解析","en":"Comprehensive analysis of genetic abnormalities in solid tumors"},"summary":{"aims":{"ja":"全エクソンシーケンスを含む網羅的ゲノム解析により固形腫瘍の遺伝学的背景を明らかにする","en":"Through an integrated genetic study involving whole exome sequencing analysis, we delineate the landscape of genetic alterations in solid tumors."},"methods":{"ja":"通常診療において何らかの病変に対する上部消化管内視鏡検査が予定され、事前に同意が得られた患者さんの、生検時に採取された正常胃粘膜から胃腺管を抽出し、全エクソン解析を行った。","en":"We collected additional biopsied gastric tissues from nine subjects who underwent diagnostic endoscopy and biopsy for upper gastrointestinal symptoms. Genomic DNA isolated from each gland was subjected to whole exome sequencing."},"targets":{"ja":"胃がん既往の無いヘリコバクターピロリ未感染者","en":"Nine subjects without Helicobacter pylori (Hp) infection or gastric cancer were included as the healthy population. Two biopsies of normal gastric mucosa were obtained from each subject."},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"胃癌既往の無いヘリコバクターピロリ未感染者（健常集団）：9名\n（日本人）","en":"Nine subjects without Hp infection or gastric cancer (healthy population)\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"胃がん既往の無いヘリコバクターピロリ未感染者9名の正常胃粘膜生検検体および末梢血から抽出したDNAを用いたExome解析の結果をbamファイル形式で提供する。","en":"Exome sequencing analysis in nine subjects without Hp infection or gastric cancer (healthy population) was performed using DNAs extracted from gastric mucosa and peripheral blood cells. The data are provided as bam format files."},"dataProviders":[{"name":{"ja":"小川 誠司","en":"Seishi Ogawa"},"organization":{"name":{"ja":"京都大学 大学院医学研究科","en":"Kyoto University Graduate School of Medicine"}}}],"researchProjects":[{"name":{"ja":"固形腫瘍における遺伝子異常の網羅的解析 / 腫瘍生物学講座","en":"Comprehensive analysis of genetic abnormalities in solid tumors / Department of Pathology and Tumor Biology"},"url":{"ja":[{"url":"https://patho-tumor-bio.med.kyoto-u.ac.jp/","text":"https://patho-tumor-bio.med.kyoto-u.ac.jp/"}],"en":null}}],"grants":[{"title":{"ja":"加齢や炎症に伴う組織の再構築と機能低下","en":"Tissue remodeling and functional deterioration associated with aging and inflammation"},"agency":{"ja":"日本医療研究開発機構 革新的先端研究開発支援事業（AMED-CREST）","en":"Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST)"},"grantIds":["JP20gm1110011"]}],"relatedPublications":[{"title":"Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations","doi":"https://doi.org/10.1007/s10120-021-01191-8","datasets":["JGAD000424"]}],"datasets":["JGAD000424"],"controlledAccessUsers":[]}