{"id":"hum0272","version":3,"url":"https://humandbs.dbcls.jp/research/hum0272/v3","datePublished":"2024-11-13","versions":[{"version":1,"datePublished":"2021-12-20"},{"version":2,"datePublished":"2022-02-07"},{"version":3,"datePublished":"2024-11-13"}],"title":{"ja":"メラノーマ等、皮膚腫瘍病変の免疫状態の解析","en":"Analysis of the immune status of melanoma and other skin tumors"},"summary":{"aims":{"ja":"メラノーマなどの皮膚腫瘍検体を用いた、がん細胞や免疫細胞などの遺伝子発現、体細胞遺伝子変異の解析","en":"Analysis of gene expression and somatic gene mutation in tumor cells and immune cells using skin tumor samples such as melanoma"},"methods":{"ja":"whole exome sequencing解析、RNA sequencing解析、scRNA sequencing解析、scTCR sequencing解析、target capture sequencing解析","en":"whole exome sequencing analysis, RNA sequencing analysis, scRNA sequencing analyses, scTCR sequencing analyses, and target capture sequencing"},"targets":{"ja":"メラノーマ患者 4＋9例","en":"melanoma patients: 4 + 9 cases"},"url":{"ja":[{"url":"https://www.ho.chiba-u.ac.jp/dept/dermatology/research/res/","text":"https://www.ho.chiba-u.ac.jp/dept/dermatology/research/res/"}],"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現","en":"Sequencing, Expression profiling"},"targets":{"ja":"メラノーマ：4＋9症例\n（日本人）","en":"melanoma: 4 + 9 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome、RNA-seq、scRNA-seq、scTCR-seq、Target Capture）","en":"NGS\n(Exome, RNA-seq, scRNA-seq, scTCR-seq, Target Capture)"}},"releaseNote":{"ja":"メラノーマ12症例の腫瘍組織および末梢血から抽出したDNAを用いたTarget capture sequencing解析の結果を追加した。fastqファイル形式で提供する。","en":"DNAs extracted from tumor cells and peripheral blood cells from 12 melanoma patients were used for the target capture sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"猪爪 隆史","en":"Takashi Inozume"},"organization":{"name":{"ja":"千葉大学医学部 皮膚科","en":"Department of Dermatology, Chiba University"}}}],"researchProjects":[{"name":{"ja":"皮膚がんに対するより効果的な免疫療法の開発","en":"Development of more effective immunotherapy for skin cancer"},"url":{"ja":[{"url":"https://www.ho.chiba-u.ac.jp/dept/dermatology/research/res/","text":"https://www.ho.chiba-u.ac.jp/dept/dermatology/research/res/"}],"en":null}}],"grants":[{"title":{"ja":"抗PD-1抗体治療の効果を示す直接的バイオマーカーの検索","en":"Identification of essential biomarkers for efficacy of anti-PD-1 therapy"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["19K08744"]},{"title":{"ja":"免疫チェックポイント阻害剤の課題克服を目指した腫瘍特異的T細胞の解析","en":"Analysis of tumor-specific T cells aimed at overcoming challenges with immune checkpoint inhibitors"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["22K08424"]},{"title":{"ja":"がん抗原階層性からの腫瘍浸潤PD-1陽性T細胞の抗腫瘍免疫応答及び抑制能の解明","en":"Analysis of PD-1+ tumor-infiltrating T cells according to cancer antigen hierarchy"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["20H03694"]},{"title":{"ja":"ゲノム異常を有する腫瘍浸潤リンパ球の1細胞解析方法の開発とその臨床的意義の解明","en":"Development of a single-cell analysis method for tumor-infiltrating lymphocytes with genomic abnormalities and elucidation of its clinical significance"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん医療創生研究事業（P-CREATE）","en":"Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP21cm0106383"]}],"relatedPublications":[{"title":"TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment","doi":"https://doi.org/10.1136/jitc-2021-003134","datasets":["JGAD000391"]},{"title":"PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes","doi":"https://doi.org/10.1016/j.celrep.2022.110331","datasets":["JGAD000391"]},{"title":"Mixed Response to Cancer Immunotherapy is Driven by Intratumor Heterogeneity and Differential Interlesion Immune Infiltration","doi":"https://doi.org/10.1158/2767-9764.CRC-22-0050","datasets":["JGAD000391"]}],"datasets":["JGAD000391","JGAD000717"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000391","JGAD000717"]},{"principalInvestigator":{"ja":"山本 拓也","en":"Takuya Yamamoto"},"affiliation":{"ja":"プレシジョン免疫プロジェクト, 国立研究開発法人 医薬基盤・健康・栄養研究所","en":"Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"新規がん抗原の同定に基づく消化器がんおよび悪性黒色腫（メラノーマ）に対するワクチン開発基盤研究\r\n","en":"Basic research for vaccine development against gastrointestinal cancer and malignant melanoma based on the identification of novel cancer antigens\r\n"},"periodStart":"2024-11-12","periodEnd":"2026-03-31","datasets":["JGAD000391"]}]}