{"id":"hum0270","version":1,"url":"https://humandbs.dbcls.jp/research/hum0270/v1","datePublished":"2022-05-19","versions":[{"version":1,"datePublished":"2022-05-19"}],"title":{"ja":"ゲノムおよび遺伝子解析に基づく骨軟部腫瘍に特異的な分子病理学的異常の解明と、新規診断および治療法の開発を目指したトランスレーショナル研究","en":"Translational research for elucidating molecular and pathological abnormalities specific to bone and soft tissue tumors based on genomic and genetic analysis, and for developing new diagnostic and therapeutic strategies"},"summary":{"aims":{"ja":"小児骨肉腫に特徴的なゲノム異常の同定","en":"To identify prognosis-related genomic alterations in pediatric Osteosarcoma patients using NGS technique."},"methods":{"ja":"腫瘍及び正常組織から抽出したゲノムDNAを用いたcomprehensive cancer panelによるターゲットエクソンシークエンス解析（Ion Torrent Proton）","en":"By using a comprehensive cancer panel which amplifies coding exons of cancer-related 409 genes, candidate mutations occurred in OS were surveyed."},"targets":{"ja":"小児骨肉腫患者16症例","en":"Pediatric Osteosarcoma: 16 patients"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"小児骨肉腫：16症例\n（日本人）","en":"16 pediatric Osteosarcoma patients\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Target Capture）","en":"NGS\n(Target Capture)"}},"releaseNote":{"ja":"小児骨肉腫16症例の腫瘍組織および非腫瘍組織（もしくは末梢血）から抽出したDNAを用いた409遺伝子のTarget Capture Sequencing解析結果をfastqファイルにて提供する。","en":"DNAs extracted from tumor tissues and non-tumor tissues or peripheral blood cells of pediatric Osteosarcoma patiets were used for Target Capture sequencing of 409 cancer-related genes. Fastq files are provided."},"dataProviders":[{"name":{"ja":"米本 司","en":"Tsukasa Yonemoto"},"organization":{"name":{"ja":"千葉県がんセンター 整形外科","en":"Division of Orthopedic Surgery, Chiba Cancer Center"}}}],"researchProjects":[],"grants":[{"title":{"ja":"分子プロファイルに基づく骨肉腫の薬剤感受性マーカーの探索","en":"Molecular profiling to predict chemosensitivity for osteosarcoma"},"agency":{"ja":"科学研究費助成事業 若手研究（B）","en":"KAKENHI Grant-in-Aid for Young Scientists (B)"},"grantIds":["23791673"]},{"title":{"ja":"網羅的遺伝子発現解析による骨肉腫患者の抗がん剤感受性および肺転移規定因子 の解析","en":"Analysis of factors determining chemosensitivity and pulmonary metastasis in patients with osteosarcoma by genomic expression analysis"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["19591742"]},{"title":{"ja":"ゲノム・遺伝子発現情報からみた小児がんの臨床的特性の解明と治療への応用","en":"Genomic and gene expression profiling of pediatric solid tumors"},"agency":{"ja":"厚生労働科学研究費補助金（第3次対がん総合戦略研究事業）","en":"Grants-in-Aid by the Ministry of Health, Labor and Welfare of Japan for the Third Term Comprehensive 10-year Strategy for Cancer Control"},"grantIds":["H22-3次がん-一般-011"]}],"relatedPublications":[{"title":"CDK4 overexpression is a predictive biomarker for resistance to conventional chemotherapy in patients with osteosarcoma","doi":"https://doi.org/10.3892/or.2021.8086","datasets":["JGAD000388"]}],"datasets":["JGAD000388"],"controlledAccessUsers":[]}