{"id":"hum0269","secondaryIds":[],"version":1,"url":"https://humandbs.dbcls.jp/research/hum0269/v1","datePublished":"2021-05-25","versions":[{"version":1,"datePublished":"2021-05-25"},{"version":2,"datePublished":"2024-03-18"}],"title":{"ja":"遺伝性心血管疾患の感受性遺伝子解析研究","en":"Sensitive gene analysis of hereditary cardiovascular disease"},"summary":{"aims":{"ja":"遺伝性心血管疾患の病態解明","en":"Elucidation of the pathophysiology of patients with hereditary cardiovascular disease"},"methods":{"ja":"遺伝性心血管疾患10症例の末梢血から抽出したDNAを用いた全エクソーム解析、ならびに、遺伝性心血管疾患3症例の心筋サンプルから抽出したRNAを用いたRNAseq解析","en":"Whole exome sequencing analysis and RNA-seq analysis"},"targets":{"ja":"遺伝性心血管疾患症例","en":"hereditary cardiovascular disease"},"url":{"ja":[{"url":"http://www.cardiology.med.osaka-u.ac.jp/?page_id=37180","text":"http://www.cardiology.med.osaka-u.ac.jp/?page_id=37180"}],"en":[{"url":"http://www.cardiology.med.osaka-u.ac.jp/?page_id=37180","text":"http://www.cardiology.med.osaka-u.ac.jp/?page_id=37180"}]}},"listingSummary":{},"releaseNote":{"ja":"遺伝性心血管疾患10症例の末梢血から抽出したDNAを用いたWhole Exome Sequencing解析データ、ならびに3症例の心臓移植時の心筋サンプルから抽出したRNAを用いたRNA-seq解析データをfastqファイルにて提供する。","en":"A whole exome sequencing analysis was performed on 10 patients with hereditary cardiovascular disease using DNAs extracted from peripheral blood cells. An RNAseq was performed on 3 patients with hereditary cardiovascular disease using RNAs extracted from myocardial samples at the time of heart transplantation. Fastq format files are provided."},"dataProviders":[{"name":{"ja":"朝野 仁裕","en":"Yoshihiro Asano"},"organization":{"name":{"ja":"大阪大学 大学院医学系研究科循環器内科学","en":"Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University"}}}],"researchProjects":[{"name":{"ja":"病態分子探索グループ","en":"Molecular Genetics and Drug Discovery Group"},"url":{"ja":[{"url":"http://www.cardiology.med.osaka-u.ac.jp/?page_id=34297","text":"http://www.cardiology.med.osaka-u.ac.jp/?page_id=34297"}],"en":[{"url":"http://www.cardiology.med.osaka-u.ac.jp/?page_id=34297","text":"http://www.cardiology.med.osaka-u.ac.jp/?page_id=34297"}]}}],"grants":[{"title":{"ja":"遺伝性心筋症ゲノム解析および横断オミックス解析による新規分子標的の同定と創薬開発","en":"Identification of de novo molecular targets and drug discovery by genome analysis and trans-omics analysis of hereditary cardiomyopathy"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["19H03652"]}],"relatedPublications":[],"datasets":["JGAD000402"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000402"]}]}