{"id":"hum0268","secondaryIds":[],"version":1,"url":"https://humandbs.dbcls.jp/research/hum0268/v1","datePublished":"2021-04-09","versions":[{"version":1,"datePublished":"2021-04-09"},{"version":2,"datePublished":"2025-08-29"}],"title":{"ja":"がん組織を用いたネオアンチゲンスクリーニング","en":"Direct and comprehensive identification of neoantigens using cancer tissues"},"summary":{"aims":{"ja":"大腸がん組織のプロテオゲノミクスHLAリガンドーム解析による新規タイプがん抗原の探索","en":"Proteogenomic discovery of a novel class of cancer antigens by HLA ligandome analysis of colon cancer tissues"},"methods":{"ja":"RNA-seq、CAGE-seq、ならびにIso-seq解析を実施し、組織解析で同定済みの非コード領域由来新規がん抗原をコードする転写産物バリアントを探索した。","en":"RNA-seq, CAGE-seq and Iso-seq data were used to analyze the transcript variants coding an identified non-coding RNA-derived antigen."},"targets":{"ja":"ヒト大腸がん細胞株：1種類、大腸がん6症例","en":"Human colon cancer cell line: 1, colon cancer: 6"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"ヒト大腸がん細胞株から抽出したRNAを用いたIso-seq、CAGE-seq、RNA-seqデータ、ならびに大腸がん6症例の腫瘍組織・非腫瘍組織から抽出したRNAを用いたRNA-seqデータをfastqファイルにて提供する。","en":"RNAs extracted from human colon cancer cell line were used for Iso-seq, CAGE-seq and RNA-seq analyses. RNAs extracted from tumor tissues and non-tumor tissues from colon cancer patients were used for RNA-seq analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"金関 貴幸","en":"Takayuki Kanaseki"},"organization":{"name":{"ja":"札幌医科大学 病理学第一講座/新潟大学医学部 分子病理学分野","en":"Department of Pathology, Sapporo Medical University/Division of Molecular Pathology, Niigata University School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"プロテオゲノミクスによるlncRNAがん抗原を標的とした革新的免疫治療の開発","en":"Proteogenomic discovery of HLA presented tumor antigens that arise from non-coding RNAs"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん医療創生研究事業（P-CREATE）","en":"Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP20cm0106352"]}],"relatedPublications":[],"datasets":["JGAD000386"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000386"]}]}