{"id":"hum0263","version":1,"url":"https://humandbs.dbcls.jp/research/hum0263/v1","datePublished":"2023-07-24","versions":[{"version":1,"datePublished":"2023-07-24"}],"title":{"ja":"若年性骨髄単球性白血病における遺伝子異常の網羅的解析","en":"Comprehensive analysis of the abnormality of the genes in juvenile myelomonocytic leukemia"},"summary":{"aims":{"ja":"若年性骨髄単球性白血病のリスク層別化のための、Infinium® HumanMethylation450 BeadChip（Illumina）に代わる、簡便かつ堅牢性の保持された解析手法の開発","en":"To develop a simple and robust methylation analysis method for risk stratification of patients with juvenile myelomonocytic Leukemia."},"methods":{"ja":"NGSを用いた全ゲノムメチル化解析の方法であるDREAM法を用いて、 若年性骨髄単球性白血病のメチル化解析を行った","en":"the DREAM method; a method for whole genome methylation analysis using NGS"},"targets":{"ja":"若年性骨髄単球性白血病","en":"Juvenile myelomonocytic Leukemia"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"メチル化","en":"Methylation profiling"},"targets":{"ja":"若年性骨髄単球性白血病：149症例\n（日本人）","en":"Juvenile myelomonocytic Leukemia: 149 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（DREAM-seq）","en":"NGS\n(DREAM-seq)"}},"releaseNote":{"ja":"若年性骨髄単球性白血病149症例の腫瘍組織から抽出したDNAを用いた網羅的メチル化解析（DREAM-seq）の結果をfastqファイル形式で提供する。","en":"DREAM-seq (a method for whole genome methylation analysis) in 149 cases of juvenile myelomonocytic leukemia were performed using DNAs extracted from tumor tissues of the patients. The data are provided as fastq format files."},"dataProviders":[{"name":{"ja":"髙橋 義行","en":"Yoshiyuki Takahashi"},"organization":{"name":{"ja":"名古屋大学大学院医学系研究科 小児科学","en":"Department of Pediatrics, Nagoya University Graduate School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"次世代シーケンサーを用いた若年性骨髄単球性白血病のメチル化解析法の開発","en":"Development of a methylation analysis method for juvenile myelomonocytic leukemia using next-generation sequencing"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["18K07816"]}],"relatedPublications":[{"title":"Simple and robust methylation test for risk stratification of patients with juvenile myelomonocytic leukemia","doi":"https://doi.org/10.1182/bloodadvances.2021005080","datasets":["JGAD000398"]}],"datasets":["JGAD000398"],"controlledAccessUsers":[]}