{"id":"hum0257","secondaryIds":[],"version":1,"url":"https://humandbs.dbcls.jp/research/hum0257/v1","datePublished":"2021-12-24","versions":[{"version":1,"datePublished":"2021-12-24"},{"version":2,"datePublished":"2023-01-10"},{"version":3,"datePublished":"2026-11-04"}],"title":{"ja":"ヒト膵・胆道由来微量検体を用いた培養増幅法の研究開発","en":"Development of culturing methods amplifying micro-specimens derived from human pancreas and biliary tract tissues"},"summary":{"aims":{"ja":"ヒト膵腫瘍サブタイプの包括的解析","en":"Comprehensive analysis of human pancreatic tumor subtypes."},"methods":{"ja":"膵腫瘍組織から樹立したオルガノイドのWhole Exome sequencing、RNA sequencing、ATAC sequencing、ChIP sequencing、およびHi-C解析","en":"Whole Exome sequencing, RNA sequencing, ATAC sequencing, ChIP sequencing, and Hi-C analysis using organoids established from pancreatic tumors."},"targets":{"ja":"膵管がん、膵管内乳頭粘液性腫瘍（IPMN）","en":"Pancreatic ductal adenocarcinoma, Intraductal papillary mucinous neoplasm"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"膵管がんと膵管内乳頭粘液性腫瘍症例の腫瘍組織（RNA-seqとATAC-seqは腫瘍組織に加えて傍腫瘍組織）由来オルガノイド検体から抽出したDNA/RNAを用いたWhole Exome sequencing、RNA sequencing、ATAC sequencing、ChIP sequencing、およびHi-C解析データをfastqファイルにて提供する。","en":"DNAs/RNAs extracted from organoids established from pancreatic tumors were used for the Whole Exome sequencing, RNA sequencing, ATAC sequencing, ChIP sequencing and Hi-C analyses. Fastq files are provided."},"dataProviders":[{"name":{"ja":"立石 敬介","en":"Keisuke Tateishi"},"organization":{"name":{"ja":"東京大学医学部 消化器内科","en":"Department of Gastroenterology, The University of Tokyo"}}}],"researchProjects":[],"grants":[{"title":{"ja":"膵癌の包括的理解を目指した細胞間ネットワーク解析","en":"Comprehensive biological network analysis of pancreatic cancer"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["19K08435"]},{"title":{"ja":"クロマチン動態に基づいた膵癌の治療層別化・最適化","en":"Stratification and optimization of pancreatic cancer treatment based on chromatin dynamics"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["21K15966"]}],"relatedPublications":[{"title":"MNX1-HNF1B axis is indispensable for intraductal papillary mucinous neoplasm lineages","doi":"https://doi.org/10.1053/j.gastro.2021.12.254","datasets":["JGAD000365","JGAD000366","JGAD000367","E-GEAD-414","E-GEAD-415","E-GEAD-416","E-GEAD-417"]}],"datasets":["JGAD000366","E-GEAD-414","JGAD000367","E-GEAD-416","E-GEAD-417","JGAD000365","E-GEAD-415"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000366"]},{"principalInvestigator":{"ja":"山本 拓也","en":"Takuya Yamamoto"},"affiliation":{"ja":"プレシジョン免疫プロジェクト, 国立研究開発法人 医薬基盤・健康・栄養研究所","en":"Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"新規がん抗原の同定に基づく消化器がんおよび悪性黒色腫（メラノーマ）に対するワクチン開発基盤研究\r\n","en":"Basic research for vaccine development against gastrointestinal cancer and malignant melanoma based on the identification of novel cancer antigens\r\n"},"periodStart":"2024-11-12","periodEnd":"2027-03-31","datasets":["JGAD000366"]}]}