{"id":"hum0257","version":2,"url":"https://humandbs.dbcls.jp/research/hum0257/v2","datePublished":"2023-01-10","versions":[{"version":1,"datePublished":"2021-12-24"},{"version":2,"datePublished":"2023-01-10"}],"title":{"ja":"ヒト膵・胆道由来微量検体を用いた培養増幅法の研究開発","en":"Development of culturing methods amplifying micro-specimens derived from human pancreas and biliary tract tissues"},"summary":{"aims":{"ja":"ヒト膵腫瘍サブタイプの包括的解析","en":"Comprehensive analysis of human pancreatic tumor subtypes."},"methods":{"ja":"膵腫瘍組織から樹立したオルガノイドのWhole Exome sequencing、RNA sequencing、ATAC sequencing、ChIP sequencing、およびHi-C解析","en":"Whole Exome sequencing, RNA sequencing, ATAC sequencing, ChIP sequencing, and Hi-C analysis using organoids established from pancreatic tumors."},"targets":{"ja":"膵管がん、膵管内乳頭粘液性腫瘍（IPMN）","en":"Pancreatic ductal adenocarcinoma, Intraductal papillary mucinous neoplasm"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現\nクロマチン構造\nヒストン修飾","en":"Sequencing, Expression profiling, Chromatin structure profiling, Histone modification profiling"},"targets":{"ja":"膵管癌：17症例\n膵管内乳頭粘液性腫瘍：6症例\n（日本人）","en":"Pancreatic ductal adenocarcinoma: 17 cases\nIntraductal papillary mucinous neoplasm: 6 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome、RNA-seq、ATAC-seq、ChIP-seq、Hi-C）","en":"NGS\n(Exome, RNA-seq, ATAC-seq, ChIP-seq, Hi-C)"}},"releaseNote":{"ja":"膵管がんおよび膵管内乳頭粘液性腫瘍由来膵管がんの腫瘍組織由来オルガノイド検体から抽出したDNA/RNAを用いたRNA sequencing、ChIP sequencing、およびHi-C解析データをfastqファイルにて提供する。","en":"DNAs/RNAs extracted from organoids established from pancreatic tumors were used for the RNA sequencing, ChIP sequencing and Hi-C analyses. Fastq files are provided."},"dataProviders":[{"name":{"ja":"立石 敬介","en":"Keisuke Tateishi"},"organization":{"name":{"ja":"東京大学医学部 消化器内科","en":"Department of Gastroenterology, The University of Tokyo"}}}],"researchProjects":[],"grants":[{"title":{"ja":"膵癌の包括的理解を目指した細胞間ネットワーク解析","en":"Comprehensive biological network analysis of pancreatic cancer"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["19K08435"]},{"title":{"ja":"クロマチン動態に基づいた膵癌の治療層別化・最適化","en":"Stratification and optimization of pancreatic cancer treatment based on chromatin dynamics"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["21K15966"]}],"relatedPublications":[{"title":"MNX1-HNF1B axis is indispensable for intraductal papillary mucinous neoplasm lineages","doi":"https://doi.org/10.1053/j.gastro.2021.12.254","datasets":["JGAD000365","JGAD000366","JGAD000367","E-GEAD-414","E-GEAD-415","E-GEAD-416","E-GEAD-417"]},{"title":"HNF1B-driven three-dimensional chromatin structure for molecular classification in pancreatic cancers","doi":"https://doi.org/10.1111/cas.15690","datasets":["JGAD000365","JGAD000366","JGAD000367","JGAD000633"]}],"datasets":["JGAD000366","JGAD000633","E-GEAD-414","JGAD000367","E-GEAD-416","E-GEAD-417","JGAD000365","E-GEAD-415"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000366"]},{"principalInvestigator":{"ja":"山本 拓也","en":"Takuya Yamamoto"},"affiliation":{"ja":"プレシジョン免疫プロジェクト, 国立研究開発法人 医薬基盤・健康・栄養研究所","en":"Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"新規がん抗原の同定に基づく消化器がんおよび悪性黒色腫（メラノーマ）に対するワクチン開発基盤研究\r\n","en":"Basic research for vaccine development against gastrointestinal cancer and malignant melanoma based on the identification of novel cancer antigens\r\n"},"periodStart":"2024-11-12","periodEnd":"2026-03-31","datasets":["JGAD000366"]}]}