{"id":"hum0252","version":2,"url":"https://humandbs.dbcls.jp/research/hum0252/v2","datePublished":"2023-12-06","versions":[{"version":1,"datePublished":"2021-07-12"},{"version":2,"datePublished":"2023-12-06"},{"version":3,"datePublished":"2024-03-04"}],"title":{"ja":"ATL、HTLV-1感染症の分子基盤創出のための研究","en":"Study for molecular characteristics of adult T-cell leukemia-lymphoma and HTLV-1-associated diseases"},"summary":{"aims":{"ja":"成人T 細胞白血病（ATL）の遺伝子変異と遺伝子発現の解析を通じてATLのリスクバイオマーカーと発症メカニズムを明らかにする。Target capture sequencingを用いて成人T細胞白血病（ATL）の遺伝子変異とクローン構造を解析し、さらにRNA sequencingによって遺伝子変異の生物学的意義を検討する。","en":"Study for molecular characteristics of adult T-cell leukemia-lymphoma and HTLV-1-associated diseases"},"methods":{"ja":"Target capture sequencing、RNA sequencing（RNA-seq）、single cell RNA sequencing（scRNA-seq）、Whole genome sequencing（WGS）、scATAC-seq、ChIP-seq","en":"Target capture sequencing, RNA-seq, single cell RNA-seq (scRNA-seq), Whole genome sequencing (WGS), scATAC-seq, ChIP-seq"},"targets":{"ja":"ATL6＋4＋6症例、及びHTLV-1感染者10症例の感染細胞分画及び非感染細胞分画、並びに健常者3＋1名のCD4+T細胞（Lonzaからの購入検体）","en":"ATL 6 + 4 + 6 cases, HTLV-1 infected carrier 10 cases (infected cells and unifected cells), and 3 + 1 healthy donors"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"ATL4症例の正常細胞、バレメトスタット投薬前およびバレメトスタット投薬後の腫瘍細胞と末梢血リンパ球、並びに健常者1名のCD4+T細胞から抽出したDNA/RNAを用いたTarget Capture Sequencing、Whole genome sequencing、single cell RNA-seq、single cell ATAC-seq、ChIP-seq解析データをfastqファイルにて提供する。","en":"DNAs/RNAs extracted from non-tumor and tumor cells, or peripheral blood lymphocytes before and after valemetostat treatment from 4 ATL cases and CD4+ T cells from healthy donors were used for the target capture sequencing, whole genome sequencing, single cell RNA-seq, single cell ATAC-seq, and ChIP-seq analyses. Fastq files are provided."},"dataProviders":[{"name":{"ja":"山岸 誠","en":"Makoto Yamagishi"},"organization":{"name":{"ja":"東京大学大学院 新領域創成科学研究科","en":"Graduate School of Frontier Sciences, The University of Tokyo"}}}],"researchProjects":[],"grants":[{"title":{"ja":"ゲノム情報を基盤としたHTLV-1感染症の病態形成機序の解明及び発症リスク予知アルゴリズム開発に関する総合的研究","en":"Comprehensive study on elucidation of pathogenesis of HTLV-1 infection based on genome information and development of risk prediction algorithm"},"agency":{"ja":"日本医療研究開発機構（AMED） 新興・再興感染症に対する革新的医薬品等開発推進研究事業","en":"Research Program on Emerging and Re-emerging Infectious Diseases, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP23fk0108672"]},{"title":{"ja":"HTLV-1関連疾患の発症リスク、進展メカニズムに関するオミックス統合解析と発症予防に資する基盤的研究","en":"Development of risk stratification and prevention for HTLV-1-associated diseases based on multi-omics database"},"agency":{"ja":"日本医療研究開発機構（AMED） 新興・再興感染症に対する革新的医薬品等開発推進研究事業","en":"Research Program on Emerging and Re-emerging Infectious Diseases, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP22fk0108126"]},{"title":{"ja":"HTLV-1 感染症のエピゲノムコードの解読と戦略的創薬を目指した基礎•臨床融合データサイエンス","en":"Integrated data science for deciphering the epigenomic code and molecular network of HTLV-1 infection and strategic drug discovery"},"agency":{"ja":"日本医療研究開発機構（AMED） 新興・再興感染症研究基盤創生事業","en":"Japan Program for Infectious Diseases Research and Infrastructure, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP23wm0325056"]},{"title":{"ja":"レトロウイルス病原性と持続感染の根源となる不均一な潜伏集団を生み出す宿主エピゲノム特性の解明と治療薬開発","en":"Deep exploration for retrovirus reservoir heterogeneity and host-virus interaction by multi-phase single-cell epigenetic analysis"},"agency":{"ja":"日本医療研究開発機構（AMED） 新興・再興感染症研究基盤創生事業","en":"Japan Program for Infectious Diseases Research and Infrastructure, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP22wm0325017"]},{"title":{"ja":"シングルセルゲノミクスを用いたNOTCH1変異クローンの特性解明及び新規治療法と層別化アルゴリズムの開発","en":"Genome-based medicine and clinical stratification for NOTCH1-mutated malignant lymphomas"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP22ck0106703"]},{"title":{"ja":"アグレッシブ成人T細胞白血病リンパ腫を対象とした全国一元化レジストリ・バイオレポジトリ研究","en":"A nation-wide registry and biorepository system for patients with aggressive adult T-cell leukemia-lymphoma"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP23ck0106860"]},{"title":{"ja":"ゲノム異常とエピゲノム異常によるATLの協奏的クローン進化メカニズムの解明","en":"Mechanisms of cooperative clonal evolution of ATL by genomic and epigenomic abnormalities"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["JP21K08386"]}],"relatedPublications":[{"title":"Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma","doi":"https://doi.org/10.1038/s41467-021-25101-9","datasets":["JGAD000412"]},{"title":"Mechanisms of action and resistance in histone methylation-targeted therapy","doi":"https://doi.org/10.1038/s41586-024-07103-x","datasets":["JGAD000674"]}],"datasets":["JGAD000412","JGAD000674"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"松岡 雅雄","en":"Masao Matsuoka"},"affiliation":{"ja":"血液・膠原病・感染症内科学講座, 熊本大学大学院生命科学研究部","en":"Faculty of Life Sciences Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"悪性リンパ腫、成人T細胞白血病・リンパ腫の遺伝・病理学的検討を用いた特性および経過・治療に関する後方視的観察研究","en":"Retrospective observational study of characteristics, clinical course and treatment of malignant lymphoma and adult T-cell leukemia/lymphoma with genetic and pathological evaluations"},"periodStart":"2022-05-18","periodEnd":"2030-03-31","datasets":["JGAD000412"]},{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000412","JGAD000674"]},{"principalInvestigator":{"en":"Tomohiro Aoki"},"affiliation":{"en":"Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre"},"country":{"ja":"カナダ (オンタリオ州)","en":"Ontario, Canada"},"researchTitle":{"en":"Tumor-microenvironment ecosystem in ALCL"},"periodStart":"2025-05-07","periodEnd":"2030-02-28","datasets":["JGAD000412","JGAD000674"]}]}