{"id":"hum0251","version":1,"url":"https://humandbs.dbcls.jp/research/hum0251/v1","datePublished":"2022-10-25","versions":[{"version":1,"datePublished":"2022-10-25"}],"title":{"ja":"成人フィラデルフィア染色体陰性precursor B細胞性急性リンパ性白血病に対する多剤併用化学療法による第Ⅱ相臨床試験","en":"Phase II clinical trial of adult Philadelphia chromosome-negative precursor B-cell acute lymphocytic leukemia with combination chemotherapy"},"summary":{"aims":{"ja":"B細胞性急性リンパ性白血病に対するゲノム解析による分子病態の解明","en":"Elucidation of molecular pathology for B-cell acute lymphocytic leukemia (B-ALL) by genomic analysis"},"methods":{"ja":"RNA Sequencing、Target Capture Sequencing","en":"RNA Sequencing and target capture sequencing analyses"},"targets":{"ja":"フィラデルフィア染色体陰性B細胞性急性リンパ性白血病（B-ALL）153症例","en":"Philadelphia chromosome-negative (Ph-negative) B-ALL"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現\n配列決定","en":"Expression profiling, Sequencing"},"targets":{"ja":"フィラデルフィア染色体陰性B-ALL：153症例\n（日本人）","en":"153 patients with Ph-negative B-ALL\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq、Target Capture）","en":"NGS\n(RNA-seq, Target Capture)"}},"releaseNote":{"ja":"フィラデルフィア染色体陰性B細胞性急性リンパ性白血病153症例の白血病細胞から抽出したDNA/RNAを対象としたRNA SequencingおよびTarget Capture Sequencing解析データをfastqおよびbamファイルにて提供する。","en":"DNA/RNA extracted from leukemia cells of 153 patients with Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia were used for RNA Sequencing and Target Capture Sequencing analyses. Fastq and bam files are provided."},"dataProviders":[{"name":{"ja":"八田 善弘","en":"Yoshihiro Hatta"},"organization":{"name":{"ja":"日本大学 医学部 内科学系血液膠原病内科学分野","en":"Division of Hematology and Rheumatology, Nihon University School of Medicine"}}}],"researchProjects":[{"name":{"ja":"JALSG Ph(-)B-ALL213","en":"JALSG Ph(-)B-ALL213"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"AYA世代急性リンパ性白血病の小児型治療法および遺伝子パネル診断による層別化治療に関する研究","en":"Treatment with a pediatric protocols and stritified strateiesy by gene panel testing for adolescents and young adults with acute lymphoblastic leukemia"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP19ck0106331"]}],"relatedPublications":[{"title":"Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations","doi":"https://doi.org/10.1182/blood.2021011921","datasets":["JGAD000384"]}],"datasets":["JGAD000384"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000384"]}]}