{"id":"hum0250","version":1,"url":"https://humandbs.dbcls.jp/research/hum0250/v1","datePublished":"2021-03-29","versions":[{"version":1,"datePublished":"2021-03-29"}],"title":{"ja":"革新脳脳老化ヒト画像研究","en":"Brain Mapping by Integrated Neurotechnologies for Disease Studies: Human Brain Aging Imaging Study"},"summary":{"aims":{"ja":"機能的MRI データとアミロイドPET画像・認知機能データとの対比解析により、超早期アルツハイマー病（AD）病態変化を検出する","en":"Compare the functional MRI data with amyloid PET images and cognitive data and establish a methodologies for the very early stage of Alzheimer disease (AD)."},"methods":{"ja":"構造的MRI, 安静時機能的MRI（fMRI）、拡散テンソル画像法（DTI）、動脈スピンラベル法（ASL）などのMRI画像データを取得する","en":"Structural MRI, resting state functional MRI, diffusion tensor imaging, and arterial spin labeling will be acquired"},"targets":{"ja":"認知機能障害を認めない健常高齢者28名、記憶障害などが顕在化しているが認知症に至っていない経度認知障害（MCI）患者（ICD10：F00）11名","en":"Mild cognitive impairment (MCI) and preclinical AD individuals (ICD10: F00)"},"url":{"ja":[{"url":"https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000020292","text":"https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000020292"}],"en":[{"url":"https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000020292","text":"https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000020292"}]}},"listingSummary":{"methods":{"ja":"脳画像","en":"Brain imaging"},"targets":{"ja":"MCI：11名\n健常高齢者群：28名\n（日本人）","en":"11 MCI\n28 healthly controls\n(Japanese)"},"typeOfData":{"ja":"脳画像\n臨床情報","en":"Neuroimage\nClinical Info"}},"releaseNote":{"ja":"認知機能障害を認めない健常高齢者28名、およびMCI患者11名のMRIおよびPET画像データ、神経心理検査データを公開した。","en":"MRI and PET images and psychometric data obtained from participants (healthly elderly controls: 28, MCI: 11) were released."},"dataProviders":[{"name":{"ja":"岩坪 威","en":"Takeshi Iwatsubo"},"organization":{"name":{"ja":"東京大学大学院医学系研究科 神経病理学分野","en":"Department of Neuropathology, Graduate School of Medicine, the University of Tokyo"}}}],"researchProjects":[{"name":{"ja":"革新的技術による脳機能ネットワークの全容解明（革新脳）","en":"Brain Mapping by Integrated Neurotechnologies for Disease Studies"},"url":{"ja":[{"url":"https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000020292","text":"https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000020292"}],"en":[{"url":"https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000020292","text":"https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000020292"}]}}],"grants":[{"title":{"ja":"超早期アルツハイマー病における画像診断を用いた鍵神経回路の同定と、タウ病理進展機構の解明","en":"Identification of damaged neuronal circuits in very early Alzheimer disease patients and elucidation of molecular mechanism of tau pathology spreading"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的技術による脳機能ネットワークの全容解明プロジェクト","en":"Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP18dm0207014"]}],"relatedPublications":[],"datasets":["JGAD000383"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"安田 実樹大","en":"Yasuda Mikihiro"},"affiliation":{"ja":"理工学研究科 作元研究室, 関西学院大学"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"fMRIデータに基づく脳内ネットワークの分析手法の構築","en":"Construction of a method for analyzing brain networks based on fMRI data"},"periodStart":"2023-08-25","periodEnd":"2025-01-23","datasets":["JGAD000383"]}]}