{"id":"hum0247","version":1,"url":"https://humandbs.dbcls.jp/research/hum0247/v1","datePublished":"2021-01-04","versions":[{"version":1,"datePublished":"2021-01-04"}],"title":{"ja":"がん患者免疫状態を反映するがん遺伝子変異の探索","en":"Research for gene mutations in cancer representing immune status of the patients"},"summary":{"aims":{"ja":"ヒトメラノーマ細胞より樹立したtumor infiltrating lymphocyte（TIL）を用いた細胞治療法の確立","en":"Establishment of a tumor infiltrating lymphocytes (TIL) therapy for malignant melanoma"},"methods":{"ja":"TILのもとになったメラノーマ腫瘍細胞および末梢血peripheral blood mononuclear cells（PBMC）のエクソームシークエンス","en":"Exome sequencing of melanoma tissues for TIL production and paired peripheral blood mononuclear cells (PBMC)"},"targets":{"ja":"悪性黒色腫の腫瘍組織と非腫瘍組織","en":"human melanoma and paired PBMC"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"悪性黒色腫：3症例\n（日本人）","en":"3 malignant melanoma patients\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"悪性黒色腫3症例の腫瘍組織および非腫瘍組織（末梢血PBMC）から抽出したDNAを用いたWhole Exome Sequencingデータの解析結果をbamファイルにて提供する。","en":"DNAs extracted from tumor tissues and PBMCs of malignant melanoma patients were used for the whole exome sequencing analysis. Bam files are provided."},"dataProviders":[{"name":{"ja":"岩田 卓","en":"Takashi Iwata"},"organization":{"name":{"ja":"慶應義塾大学医学部 産婦人科学教室","en":"Department of Obsterics and Gynecology, Keio University School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"進行期悪性黒色腫(末端黒子型)に対する非骨髄破壊的前処置併用での腫瘍浸潤Tリンパ球輸注療法の安全性試験","en":"Pilot study of adoptive cell therapy using cultured tumor infiltrating lymphocytes with lympho-depleting non-myeloablative preconditioning for patients with metastatic melanoma"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP17ck0106158"]}],"relatedPublications":[{"title":"Pilot study of adoptive cell therapy using cultured tumor infiltrating lymphocytes for Japanese melanoma patients refractory to immune-checkpoint inhibitors","doi":"https://doi.org/10.1111/cas.15009","datasets":["JGAD000349","DRA010773"]}],"datasets":["JGAD000349","DRA010773"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"山本 拓也","en":"Takuya Yamamoto"},"affiliation":{"ja":"プレシジョン免疫プロジェクト, 国立研究開発法人 医薬基盤・健康・栄養研究所","en":"Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"新規がん抗原の同定に基づく消化器がんおよび悪性黒色腫（メラノーマ）に対するワクチン開発基盤研究\r\n","en":"Basic research for vaccine development against gastrointestinal cancer and malignant melanoma based on the identification of novel cancer antigens\r\n"},"periodStart":"2024-11-12","periodEnd":"2026-03-31","datasets":["JGAD000349"]}]}