{"id":"hum0233","version":1,"url":"https://humandbs.dbcls.jp/research/hum0233/v1","datePublished":"2021-05-31","versions":[{"version":1,"datePublished":"2021-05-31"}],"title":{"ja":"小児肝癌に対する国際共同臨床試験（PHITT, JPLT4）付随研究","en":"Paediatric Hepatic International Tumour Trial (JPLT4: PHITT)"},"summary":{"aims":{"ja":"本試験では、肝芽腫に加えて、小児肝細胞がんの腫瘍特性の解析を目的とし、悪性度に関与するゲノム解析および分子細胞生物学的情報を解析し、臨床経過と生物学的情報の両者を解析することで、腫瘍の生物学的性質に応じたより優れた治療戦略開発につなげることを目的としている。","en":"To characterize the genomic profile of hepatoblastoma and hepatocellular carcinoma and then to compare these data to clinical course of the patients for development of novel treatment strategies accoding to tumor biological characteristics"},"methods":{"ja":"Exome (NGS)、RNA-seq (NGS)、SNPアレイ、メチル化アレイ、WGBS (NGS)","en":"Whole Exome Sequencing (NGS), RNA-seq (NGS), SNP array, Methylation array, Whole Genome Bisulfite Sequencing (NGS)"},"targets":{"ja":"小児肝腫瘍（肝芽腫または肝細胞がん）165例","en":"165 clinical hepatoblastoma samples"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現\nメチル化\nヒストン修飾","en":"Sequencing, Expression profiling, Methylation profiling, Histone modification profiling"},"targets":{"ja":"小児肝腫瘍：165症例\n（日本人）","en":"165 pediatric hepatoblastomas\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome、RNA-seq、WGBS）\nSNP-chip\nメチル化アレイ","en":"NGS\n(Exome, RNA-seq, WGBS)\nSNP-chip\nMethylation array"}},"releaseNote":{"ja":"小児肝腫瘍165症例の腫瘍組織および非腫瘍組織から抽出したDNA/RNAを用いたExome、RNA-seq、SNPアレイ、メチル化アレイ、WGBS解析の結果をbam、txt、CEL、bigwigファイル形式で提供する。","en":"Exome, RNA-seq, SNP array, DNA methylation array and WGBS in 165 cases of pediatric hepatoblastoma were performed using DNA/RNAs extracted from tumor tissues and non-tumor tissues of patients. The data are provided as bam, txt, CEL and bigwig format files."},"dataProviders":[{"name":{"ja":"檜山 英三","en":"Eiso Hiyama"},"organization":{"name":{"ja":"広島大学自然科学研究支援開発センター","en":"Natural Science Center for Basic Research and Development, Hiroshima University"}}}],"researchProjects":[{"name":{"ja":"JPLT-2 project / Japanese study group for Pediatric Liver Tumor (JPLT)","en":"JPLT-2 project / Japanese study group for Pediatric Liver Tumor (JPLT)"},"url":{"ja":[{"url":"https://home.hiroshima-u.ac.jp/eiso/","text":"https://home.hiroshima-u.ac.jp/eiso/"}],"en":[{"url":"https://home.hiroshima-u.ac.jp/eiso/e-public/e-index.html","text":"https://home.hiroshima-u.ac.jp/eiso/e-public/e-index.html"}]}}],"grants":[{"title":{"ja":"小児胎児性固形がんに対する標準的治療法開発","en":"Development of standard treatments for childhood embryonal solid tumors"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP18CK0106332"]},{"title":{"ja":"小児がんレジストリーを用いた転移性肝芽腫に対する薬剤開発戦略としての国際共同臨床試験","en":"Clinical international collaboration trials for drug development in childhood liver tumors under the nationwide childhood cancer registry"},"agency":{"ja":"日本医療研究開発機構（AMED） 臨床研究・治験推進研究事業","en":"Project Promoting Clinical Trials for Development of New Drugs, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP18LK0201066"]},{"title":{"ja":"ヒト上皮性腫瘍の発生・進展機構の解明と新規治療標的の同定","en":"Elucidation of initiation and progression mechanism of human epithelial tumors towards identification of novel therapeutic targets"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん医療創生研究事業（P-CREATE）","en":"Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP19cm0106502"]},{"title":{"ja":"バイオバンクの構築と臨床情報データベース化","en":"Establishment of a Biobank and Creation of a Database of Clinical Information"},"agency":{"ja":"日本医療研究開発機構（AMED） オーダーメイド医療の実現プログラム事業","en":"Tailor-Made Medical Treatment with the BioBank Japan Project (BBJ), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP16km0305001"]},{"title":{"ja":"難治性小児悪性固形腫瘍における診断バイオマーカーの同定と新規治療法の開発に関する研究","en":"Identification of new diagnostic biomarkers and development of new therapeutic strategies in intractable childhood malignant solid tumors"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP16ck0106070"]},{"title":{"ja":"一細胞解析法を応用した小児腫瘍のCancer fluid biopsyの確立","en":"Cancer fluid biopsy for childhood malignancies using one cell analysis"},"agency":{"ja":"科学研究費助成事業 基盤研究（A）","en":"KAKENHI Grant-in-Aid for Scientific Research (A)"},"grantIds":["15H02567"]},{"title":{"ja":"小児がん研究グループによる小児肝がんの海外診療状況調査と国際共同臨床研究基盤整備","en":"Study of clinical states and infrastructure development of International co-operative clinical trial for childhood liver tumors by children's cancer study group"},"agency":{"ja":"科学研究費助成事業 基盤研究（A）","en":"KAKENHI Grant-in-Aid for Scientific Research (A)"},"grantIds":["16H02778"]},{"title":{"ja":"一生細胞解析による小児腫瘍における次世代Cancer Liquid Biopsy","en":"Next-generation cancer liquid biopsy of childhood cancers using single cell analysis"},"agency":{"ja":"科学研究費助成事業 基盤研究（A）","en":"KAKENHI Grant-in-Aid for Scientific Research (A)"},"grantIds":["19H01056"]}],"relatedPublications":[],"datasets":["JGAD000334"],"controlledAccessUsers":[{"principalInvestigator":{"en":"Jinyan Huang"},"affiliation":{"en":"Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China. Biomedical big data center, the First Affiliated Hospital, Zhejiang University"},"country":{"ja":"中国","en":"China"},"researchTitle":{"en":"Comprehensive analysis of alternative splicing in malignant tumors"},"periodStart":"2022-03-15","periodEnd":"2024-01-01","datasets":["JGAD000334"]},{"principalInvestigator":{"en":"Weng Chuan Peng"},"affiliation":{"en":"Research, Princess Maxima Center for Pediatric Oncology"},"country":{"ja":"オランダ","en":"Netherlands"},"researchTitle":{"en":"Towards understanding pediatric liver tumors"},"periodStart":"2023-08-21","periodEnd":"2027-06-01","datasets":["JGAD000334"]},{"principalInvestigator":{"en":"Tianzhong Yang"},"affiliation":{"en":"Childhood Cancer Genomic Group  Division of Biostatistics, University of Minnesota"},"country":{"ja":"アメリカ合衆国 (ミネソタ州)","en":"Minnesota, United States"},"researchTitle":{"en":"Evaluating germline genetic risk factors of hepatoblastoma onset and survival"},"periodStart":"2022-09-26","periodEnd":"2025-09-03","datasets":["JGAD000334"]},{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000334"]},{"principalInvestigator":{"en":"Yujie Tang"},"affiliation":{"en":"Department of Histoembryology, Genetics and Developmental Biology, College of Basic Medical Sciences, Shanghai Jiao Tong University"},"country":{"ja":"中国","en":"China"},"researchTitle":{"en":"The key molecular mechanisms underlying the oncogenesis and progression of neuroblastoma and hepatoblastoma"},"periodStart":"2023-03-08","periodEnd":"2027-12-31","datasets":["JGAD000334"]},{"principalInvestigator":{"en":"Xin Chen"},"affiliation":{"en":"Cancer Biology Program, University of Hawaii Cancer Center"},"country":{"ja":"アメリカ合衆国 (ハワイ州)","en":"Hawaii, United States"},"researchTitle":{"en":"Wnt/beta-Catenin or Hippo/YAP target gene expression in hepatoblastoma"},"periodStart":"2023-04-25","periodEnd":"2025-05-26","datasets":["JGAD000334"]},{"principalInvestigator":{"ja":"平尾 洸樹","en":"Hiroki Hirao"},"affiliation":{"ja":"小児外科・移植外科, 熊本大学","en":"Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"肝芽腫におけるSOX9の発現解析","en":"SOX9 expression analysis in Hepatoblastoma"},"periodStart":"2024-04-16","periodEnd":"2026-03-31","datasets":["JGAD000334"]},{"principalInvestigator":{"en":"Naiyang Fu"},"affiliation":{"en":"ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research"},"country":{"ja":"オーストラリア (ビクトリア州)","en":"Victoria, Australia"},"researchTitle":{"en":"MOLECULAR PROFILING OF HUMAN AND MOUSE LIVER TUMOUR DATASETS (MHMT)"},"periodStart":"2026-04-27","periodEnd":"2028-11-01","datasets":["JGAD000334"]}]}