{"id":"hum0229","version":1,"url":"https://humandbs.dbcls.jp/research/hum0229/v1","datePublished":"2020-05-15","versions":[{"version":1,"datePublished":"2020-05-15"}],"title":{"ja":"老化・神経疾患における分子マーカーの探索と分子基盤の解明","en":"Identification and characterization of molecular markers in aging and neuronal disorders"},"summary":{"aims":{"ja":"血液中を流れる細胞のシングルセルRNA-seq（scRNA-seq）を行い、老化に関連する細胞や分子の同定を行う","en":"Identification of age associated molecular markers from blood cells using a single-cell RNA-seq technology"},"methods":{"ja":"10X Genomicsシングルセルキットを用いたscRNA-seq","en":"Single-cell RNA-seq using 10X Genomics library kit"},"targets":{"ja":"スーパーセンチナリアン（110歳以上）7名、その家族の内2名、ならびに、直接血縁関係のない対照者2名","en":"Supercentenarian (over 110 years old), family members, and unrelated donors"},"url":{"ja":[{"url":"https://www.riken.jp/research/labs/ims/transcript_tech/index.html","text":"https://www.riken.jp/research/labs/ims/transcript_tech/index.html"}],"en":[{"url":"https://www.riken.jp/en/research/labs/ims/transcript_tech/index.html","text":"https://www.riken.jp/en/research/labs/ims/transcript_tech/index.html"}]}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"スーパーセンチナリアン（110歳以上）：7名\n家族：2名\n血縁関係のない対照群：2名\n（日本人）","en":"7 supercentenarians\n2 family members\n2 unrelated donors\n(Japanese)"},"typeOfData":{"ja":"NGS\n（scRNA-seq）","en":"NGS\n(scRNA-seq)"}},"releaseNote":{"ja":"スーパーセンチナリアン（110歳以上）7名、その家族の内2名、ならびに、血縁関係のない対照者2名の血液中の細胞から抽出したRNAを用いたscRNA-seq解析の結果をfastqファイルにて提供する。","en":"RNAs extracted from blood cells from 7 supercentenarians (over 110 years old), 2 family members and 2 unrelated donors were used for the single-cell RNA sequencing analysis (fastq files)."},"dataProviders":[{"name":{"ja":"ピエロ・カルニンチ","en":"Piero Carninci"},"organization":{"name":{"ja":"理化学研究所 生命医科学研究センター","en":"RIKEN Center for Integrative Medical Sciences"}}}],"researchProjects":[],"grants":[],"relatedPublications":[{"title":"Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.","doi":"https://doi.org/10.1073/pnas.1907883116","datasets":["JGAD000324"]}],"datasets":["JGAD000324"],"controlledAccessUsers":[{"principalInvestigator":{"en":"Bo Li"},"affiliation":{"en":"Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center"},"country":{"ja":"アメリカ合衆国 (テキサス州)","en":"Texas, United States"},"researchTitle":{"ja":"Using peripheral T cell repertoire as an immune reporter to detect early-stage ovarian cancer","en":"Using peripheral T cell repertoire as an immune reporter to detect early-stage ovarian cancer"},"periodStart":"2020-08-17","periodEnd":"2022-05-24","datasets":["JGAD000324"]},{"principalInvestigator":{"en":"elizabeth gaskell"},"affiliation":{"en":"Broad Institute"},"country":{"ja":"アメリカ合衆国","en":"United States"},"researchTitle":{"en":"Investigating transcriptomic and epigenomic alterations over human aging"},"periodStart":"2022-11-15","periodEnd":"2026-08-12","datasets":["JGAD000324"]},{"principalInvestigator":{"en":"Mohammad Mahdi Karimi"},"affiliation":{"en":"Comprehensive Cancer Centre, King's College London"},"country":{"ja":"イギリス","en":"United Kingdom"},"researchTitle":{"en":"Functional role of transposable elements in ageing"},"periodStart":"2023-07-18","periodEnd":"2025-06-06","datasets":["JGAD000324"]},{"principalInvestigator":{"en":"feng li"},"affiliation":{"en":"Biotherapy Center, The First Affiliated Hospital of Zhengzhou University"},"country":{"ja":"中国","en":"China"},"researchTitle":{"en":"Study to Improve Persistence and Antitumor Activity of CAR-T Cells"},"periodStart":"2026-09-25","periodEnd":"2027-01-31","datasets":["JGAD000324"]}]}