{"id":"hum0226","version":1,"url":"https://humandbs.dbcls.jp/research/hum0226/v1","datePublished":"2021-06-04","versions":[{"version":1,"datePublished":"2021-06-04"}],"title":{"ja":"上部消化管腫瘍のゲノム・遺伝子解析とその臨床病理学的意義の解明","en":"Genomic and genetic analysis of upper gastrointestinal tumors and elucidation of its clinicopathological significance."},"summary":{"aims":{"ja":"アジアにおける胃がんの素因となるライフスタイルと生殖細胞変異の同定","en":"Identification of lifestyle and germline mutations (genetic factors) that predispose to gastric cancer in an Asian population"},"methods":{"ja":"全エクソームシークエンス解析および全トランスクリプトームシークエンス解析","en":"Whole exome sequencing (NGS) and whole transcriptome seuquencing (NGS) analyses"},"targets":{"ja":"胃がん141症例","en":"Stomach adenocarcinoma patients"},"url":{"ja":[{"url":"https://www.genome.rcast.u-tokyo.ac.jp/日本人の胃がんリスクとなる遺伝的背景と生活習/","text":"https://www.genome.rcast.u-tokyo.ac.jp/日本人の胃がんリスクとなる遺伝的背景と生活習/"}],"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現","en":"Sequencing, Expression profiling"},"targets":{"ja":"胃癌：141症例\n（日本人）","en":"141 stomach adenocarcinomas\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome、RNA-seq）","en":"NGS\n(Exome, RNA-seq)"}},"releaseNote":{"ja":"胃がん141症例の手術摘出切片の腫瘍組織および非腫瘍組織から抽出したDNA、RNAを用いたWhole Exome Sequencing解析およびRNA-seq解析の結果をfastqファイルにて提供する。","en":"DNA and RNA extracted from tumor and non-tumor tissues of surgically resected specimens from 141 gastric cancer cases were used for whole exome sequencing and RNA-seq analyses. Fastq files are provided."},"dataProviders":[{"name":{"ja":"油谷 浩幸","en":"Hiroyuki Aburatani"},"organization":{"name":{"ja":"東京大学先端科学技術研究センター","en":"RCAST, the University of Tokyo"}}}],"researchProjects":[{"name":{"ja":"ゲノムサイエンス分野","en":"Genome Science laboratory"},"url":{"ja":[{"url":"https://www.genome.rcast.u-tokyo.ac.jp/ja/research","text":"https://www.genome.rcast.u-tokyo.ac.jp/ja/research"}],"en":[{"url":"https://www.genome.rcast.u-tokyo.ac.jp/en/research","text":"https://www.genome.rcast.u-tokyo.ac.jp/en/research"}]}}],"grants":[{"title":{"ja":"統合的ゲノム解析によるがん細胞集団進化の解明","en":"Elucidation of the evolution of cancer cell populations by integrative genomic analysis"},"agency":{"ja":"科学研究費助成事業 基盤研究（S）","en":"KAKENHI Grant-in-Aid for Scientific Research (S)"},"grantIds":["24221011"]},{"title":{"ja":"がんと間質との相互依存性シグナルの包括的理解","en":"Comprehensive understanding of interdependent signaling between cancer and the stroma"},"agency":{"ja":"科学研究費助成事業 基盤研究（A）","en":"KAKENHI Grant-in-Aid for Scientific Research (A)"},"grantIds":["16H02481"]},{"title":{"ja":"ヒト上皮性腫瘍の発生・進展機構の解明と新規治療標的の同定","en":"Identification of the mechanism of development and progression of human epithelial tumors and the novel therapeutic targets"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん医療創生研究事業（P-CREATE）","en":"Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP19cm0106502"]},{"title":{"ja":"液性免疫に焦点を当てた胃癌ゲノミクスの多様性解明と介入法探索","en":"Elucidation of the diversity of gastric cancer genomics with a focus on humoral immunity and the exploration of intervention methods."},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん医療創生研究事業（P-CREATE）","en":"Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP19cm0106551"]},{"title":{"ja":"国際共同研究に資する大規模日本人がんゲノム・オミックス・臨床データ統合解析とゲノム医療推進に向けた知識基盤構築","en":"Integrated analysis of large-scale Japanese cancer genomic, omics, and clinical data for international collaborative research and construction of a knowledge base for the promotion of genomic medicine"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP20ck0106547"]}],"relatedPublications":[{"title":"Defined lifestyle and germline factors predispose Asian populations to gastric cancer","doi":"https://doi.org/10.1126/sciadv.aav9778","datasets":["JGAD000322","JGAD000323","JGAD000320","JGAD000321"]}],"datasets":["JGAD000322","JGAD000323"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000323"]},{"principalInvestigator":{"ja":"牛久 哲男","en":"Tetsuo Ushiku"},"affiliation":{"ja":"人体病理学・病理診断学分野, 東京大学","en":"Department of Pathology, Graduate School of Medicine, The University of Tokyo"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"上部消化管腫瘍のゲノム・遺伝子解析とその臨床病理学的意義の解明","en":"Genetic analysis of upper gastrointestinal tumors and their clinicopathological significance"},"periodStart":"2023-03-24","periodEnd":"2028-03-31","datasets":["JGAD000322","JGAD000323"]}]}