{"id":"hum0217","version":1,"url":"https://humandbs.dbcls.jp/research/hum0217/v1","datePublished":"2020-03-02","versions":[{"version":1,"datePublished":"2020-03-02"}],"title":{"ja":"大腸ポリープから癌への進展を予測する遺伝子変化の同定","en":"Identification of genetic alterations predicting cancer progression from colorectal polyps"},"summary":{"aims":{"ja":"大腸鋸歯状病変（鋸歯状ポリープ）の発癌機序を明らかにすること","en":"To clarify molecular and clinicopathological characteristics of colorectal serrated lesions"},"methods":{"ja":"39遺伝子のTarget Capture Sequencing（NGS）","en":"Targeted capture sequencing analysis of 39 genes mutated in colorectal cancers and/or serrated lesions"},"targets":{"ja":"大腸鋸歯状病変（鋸歯状ポリープ）50症例（腫瘍組織）","en":"50 serrated lesions, including TSAs, SSAs and microvesicular hyperplastic polyps"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"大腸鋸歯状病変（鋸歯状ポリープ）：50症例\n（日本人）","en":"50 colorectal serrated lesions\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Target Capture）","en":"NGS\n(Target Capture)"}},"releaseNote":{"ja":"50名の大腸鋸歯状病変（鋸歯状ポリープ）から抽出したDNAを用いた39遺伝子のTarget Capture Sequencing解析結果をfastqファイルにて提供する。","en":"DNAs extracted from 50 colorectal serrated lesions were used for a target capture sequencing analysis for 39 genes. Fastq files are provided."},"dataProviders":[{"name":{"ja":"澤田 武","en":"Takeshi Sawada"},"organization":{"name":{"ja":"金沢大学がん進展制御研究所 腫瘍制御研究分野","en":"Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University"}}}],"researchProjects":[],"grants":[{"title":{"ja":"大腸鋸歯状腺腫を前癌病変とする新たな大腸発癌経路の同定と発癌メカニズムの解明","en":"Molecular analysis of traditional serrated adenoma as a candidate precursor of alternative serrated pathway"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["16K09304"]},{"title":{"ja":"先進ゲノム解析研究推進プラットフォーム","en":"Platform for Advanced Genome Science"},"agency":{"ja":"科学研究費助成事業 新学術領域研究（研究領域提案型）","en":"KAKENHI Grant-in-Aid for Scientific Research on Priority Areas (Research in a proposed research area)"},"grantIds":["16H06279"]},{"title":{"ja":"大腸鋸歯状病変から高悪性度大腸癌に至る発癌経路の同定と内視鏡治療、化学療法への応用","en":"Identification of carcinogenic pathway from serrated precursor lesions to poor-prognosis colon cancer"},"agency":{"ja":"武田科学振興財団 医学系研究奨励","en":"Grant-in-Aid from the Takeda Science Foundation"},"grantIds":null},{"title":{"ja":"大腸鋸歯状腺腫の発癌メカニズムの解明と内視鏡治療への応用","en":"Identification of carcinogenic mechanism of colorectal traditional serrated adenoma and application for endoscopic treatment"},"agency":{"ja":"内視鏡医学研究振興財団","en":"Grant-in-Aid from the Japanese Foundation for Research and Promotion of Endoscopy"},"grantIds":null},{"title":{"ja":"大腸鋸歯状腺腫を前癌病変とする大腸発癌機構の分子学的解明","en":"Molecular analysis of alternative serrated pathway originating from colorectal traditional serrated adenoma"},"agency":{"ja":"金沢大学がん進展制御研究所共同研究（平成29年度、30年度）","en":"Collaborative Research Grant of Cancer Research Institute, Kanazawa University"},"grantIds":null}],"relatedPublications":[{"title":"Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum","doi":"https://doi.org/10.1371/journal.pone.0229262","datasets":["JGAD000303"]}],"datasets":["JGAD000303"],"controlledAccessUsers":[]}