{"id":"hum0216","version":4,"url":"https://humandbs.dbcls.jp/research/hum0216/v4","datePublished":"2021-04-13","versions":[{"version":1,"datePublished":"2020-02-07"},{"version":2,"datePublished":"2020-09-25"},{"version":3,"datePublished":"2021-03-29"},{"version":4,"datePublished":"2021-04-13"}],"title":{"ja":"消化管癌を含む固形癌患者における免疫状態の解明と臨床的意義に関する研究 / 新規免疫療法や併用療法開発を目指した固形癌患者の免疫状態の解析","en":"Analyses of immune status of patients with solid tumors including gastrointestinal cancer / Investigation of anti-tumor immunological response in solid tumors"},"summary":{"aims":{"ja":"消化器癌を含む固形癌の免疫状態を明らかにする。また、抗腫瘍免疫応答の解明のため、体細胞遺伝子における変異負荷を調査する。","en":"To elucidate immune status of solid tumors including gastrointestinal cancer and to investigate tumor mutation burden for clarification of anti-tumor immuno-response."},"methods":{"ja":"whole exome sequecing解析","en":"whole exome sequencing analysis"},"targets":{"ja":"2015-2016年に肺腺がん摘出手術を実施した17症例（腫瘍組織＋ペア非腫瘍組織）\n2017-2019年においてPD-1阻害治療を実施した進行悪性腫瘍患者40症例（腫瘍組織＋ペア非腫瘍組織）\n2015-2016年に胃がん手術を実施した23症例（腫瘍組織＋ペア非腫瘍組織）\n大腸がん7症例（腫瘍組織＋ペア非腫瘍組織）","en":"17 patients with lung adenocarcinomas who underwent surgery from 2015-2016\n40 patients with malignancies who received PD-1 blackade therapy from 2017 to 2019\n23 patients with gastric cancers who underwent surgery from 2015 to 2016\n7 patients with colorectal cancer"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"肺腺癌：17症例\n胃癌：26＋23症例\n肺癌：9症例\n悪性黒色腫：5症例\n大腸癌：7症例\n（日本人）","en":"17 patients with lung adenocarcinoma\n26 + 23 patients with gastric cancer\n9 patients with lung cancer\n5 patients with malignant melanoma\n7 patients with cololectal cancer\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"大腸がん7症例（腫瘍組織およびペア非腫瘍組織、1症例は横行結腸の腫瘍組織、S状結腸の腫瘍組織、および非腫瘍組織）から抽出したDNAを用いた全エクソームシークエンス解析の結果をfastqファイルにて提供する。SureSelect Human All Exon Kit v5によりDNAライブラリを作成し、NovaSeq 6000（Illumina）にて平均長150塩基を解読した（paired-end）。","en":"DNAs extracted from matched tumor and non-tumor tissues from 7 patients with colorectal cancer were used for the whole exome sequencing (fastq files). DNA libraries were established with a SureSelect Human All Exon Kit v5 and sequenced by Illumina NovaSeq 6000 system (paired-end; 150 bp)."},"dataProviders":[{"name":{"ja":"西川 博嘉","en":"Hiroyoshi Nishikawa"},"organization":{"name":{"ja":"国立がん研究センター 先端医療開発センター 免疫TR分野","en":"Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center"}}}],"researchProjects":[],"grants":[{"title":{"ja":"先端的がん免疫モニタリング法開発体制に関する研究","en":"Establishment of an advanced system of immune monitoring"},"agency":{"ja":"国立がん研究センター研究開発費","en":"The National Cancer Center Research and Development Fund"},"grantIds":["28-A-7"]},{"title":{"ja":"がん免疫療法抵抗性を解除する新規治療法の臨床展開に向けた開発研究","en":"Development of novel treatment for immunotherapy-resistant cancer"},"agency":{"ja":"国立がん研究センター研究開発費","en":"The National Cancer Center Research and Development Fund"},"grantIds":["31-A-7"]},{"title":{"ja":"がん細胞および免疫応答解析に基づくがん免疫療法効果予測診断法の確立","en":"Establishment of predictive methods for cancer immunotherapy based on the evaluation of cancer cells and immune responses"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん医療創生研究事業（P-CREATE）","en":"Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP16cm0106301"]}],"relatedPublications":[{"title":"Blockade of EGFR improves responsiveness to PD1 blockade in EGFR-mutated non-small cell lung cancer","doi":"https://doi.org/10.1126/sciimmunol.aav3937","datasets":["JGAD000302"]},{"title":"The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies","doi":"https://doi.org/10.1038/s41590-020-0769-3","datasets":["JGAD000344"]},{"title":"Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer","doi":"https://doi.org/10.1172/jci.insight.137365","datasets":["JGAD000385"]}],"datasets":["JGAD000302","JGAD000327","JGAD000344","JGAD000385"],"controlledAccessUsers":[{"principalInvestigator":{"en":"Youping Deng"},"affiliation":{"en":"Department of Complementary & Integrative Medicine, University of Hawaii Manoa"},"country":{"ja":"アメリカ合衆国 (ハワイ州)","en":"Hawaii, United States"},"researchTitle":{"ja":"Identification of driver genes and somatic mutations for lung cancer diagnosis and prognosis","en":"Identification of driver genes and somatic mutations for lung cancer diagnosis and prognosis"},"periodStart":"2018-10-04","periodEnd":"2029-07-10","datasets":["JGAD000302","JGAD000344"]},{"principalInvestigator":{"ja":"河野 隆志","en":"Takashi Kohno"},"affiliation":{"ja":"ゲノム生物学研究分野, 国立研究開発法人国立がん研究センター研究所","en":"Division of Genome Biology, National Cancer Center Research Institute"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"AYA(Adolescence and Young Adult)世代がんの個別化予防に資する遺伝要因の同定を目指す研究","en":"Identification of genetic risk factors in AYA(Adolescence and Young Adult) cancer"},"periodStart":"2021-12-02","periodEnd":"2028-12-31","datasets":["JGAD000302","JGAD000327","JGAD000385"]},{"principalInvestigator":{"ja":"中岡 博史","en":"Hirofumi Nakaoka"},"affiliation":{"ja":"腫瘍ゲノム研究部, 公益財団法人佐々木研究所","en":"Department of Cancer Genome Research, Sasaki Institute"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"肺がん遺伝子解析研究","en":"Genetic analysis of lung cancer"},"periodStart":"2022-08-17","periodEnd":"2026-07-23","datasets":["JGAD000302","JGAD000344"]},{"principalInvestigator":{"ja":"山本 拓也","en":"Takuya Yamamoto"},"affiliation":{"ja":"プレシジョン免疫プロジェクト, 国立研究開発法人 医薬基盤・健康・栄養研究所","en":"Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"新規がん抗原の同定に基づく消化器がんおよび悪性黒色腫（メラノーマ）に対するワクチン開発基盤研究\r\n","en":"Basic research for vaccine development against gastrointestinal cancer and malignant melanoma based on the identification of novel cancer antigens\r\n"},"periodStart":"2024-11-12","periodEnd":"2026-03-31","datasets":["JGAD000344"]}]}