{"id":"hum0215","version":1,"url":"https://humandbs.dbcls.jp/research/hum0215/v1","datePublished":"2022-09-28","versions":[{"version":1,"datePublished":"2022-09-28"}],"title":{"ja":"日本人の全ゲノム、RNA解析を基盤とした老年病関連分子の同定と解析","en":"Whole genome and RNA analysis of geriatric disease in Japanese"},"summary":{"aims":{"ja":"アルツハイマー病の関連遺伝子群を同定し予知診断、治療に応用する","en":"Application to future medicine by analyzing Alzheimer's disease-associated genes"},"methods":{"ja":"血液細胞の網羅的遺伝子発現解析（RNA-seq）","en":"Whole RNA-seq of blood cells"},"targets":{"ja":"アルツハイマー病317症例、軽度認知障害432症例および、認知機能正常107名（計856名）","en":"Alzheimer's disease, mild cognitive impairment, and healthy individuals"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"アルツハイマー病：317症例\n軽度認知障害：432症例\n認知機能正常：107名\n（日本人）","en":"Alzheimer's disease: 317 cases\nMild cognitive impairment: 432 cases\n107 Healthy controls\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"アルツハイマー病317症例、軽度認知障害432症例および、認知機能正常107名（計856名）の末梢血より抽出したRNAを用いたRNA-seq解析データから算出したTPMデータをcsvファイルにて提供する。","en":"RNAs extracted from peripheral blood cells of Alzheimer's disease, mild cognitive impairment, and healthy controls were used for the whole RNA-seq analysis. TPM data calculated from NGS (RNA-seq) are provided (csv)."},"dataProviders":[{"name":{"ja":"尾崎 浩一","en":"Kouichi Ozaki"},"organization":{"name":{"ja":"国立長寿医療研究センター 研究所 メディカルゲノムセンター","en":"Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology"}}}],"researchProjects":[],"grants":[{"title":{"ja":"老年病の精密医療実現に向けた疾患遺伝子機能解明とゲノム−トランスクリプトーム解析研究（21-23）","en":"Genomic and transcriptome analysis for geriatric diseases."},"agency":{"ja":"長寿医療研究開発費","en":"Research Funding for Longevity Sciences from the NCGG"},"grantIds":["21-23"]},{"title":{"ja":"日本人認知症ゲノム解析を出発点としたオミックス-臨床情報統合解析による疾患関連パスウェーイの解析から診断、治療への応用","en":"Integrative analysis for omics and clinical data to facilitate the precision medicine for dementia."},"agency":{"ja":"厚生労働科学研究費補助金 認知症政策研究","en":"Health, Labour and Welfare Sciences Research Grants for Research on Dementia"},"grantIds":["H30-認知症-一般-004"]}],"relatedPublications":[{"title":"Identification of potential blood biomarkers for early diagnosis of Alzheimer's disease through immune landscape analysis","doi":"https://doi.org/10.1038/s41514-022-00096-9","datasets":["JGAD000651"]}],"datasets":["JGAD000651"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"スタンドレー ダーロン","en":"Daron Standley"},"affiliation":{"ja":"微生物病研究所, 大阪大学","en":"Department of Genome Informatics, RIMD, Osaka University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"免疫レパトア解析によるアルツハイマー型認知症特異的獲得免疫応答の検出","en":"Detection of Alzheimer’s Disease–Specific Adaptive Immune Responses via Immune Repertoire Analysis"},"periodStart":"2025-06-30","periodEnd":"2026-09-29","datasets":["JGAD000651"]}]}