{"id":"hum0214","secondaryIds":[],"version":1,"url":"https://humandbs.dbcls.jp/research/hum0214/v1","datePublished":"2020-10-09","versions":[{"version":1,"datePublished":"2020-10-09"},{"version":2,"datePublished":"2021-03-05"},{"version":3,"datePublished":"2021-04-28"},{"version":4,"datePublished":"2022-01-21"},{"version":5,"datePublished":"2022-03-09"},{"version":6,"datePublished":"2022-08-25"},{"version":7,"datePublished":"2023-03-28"},{"version":8,"datePublished":"2023-07-06"},{"version":9,"datePublished":"2024-02-08"},{"version":10,"datePublished":"2026-06-09"}],"title":{"ja":"ヒト免疫系の機能ゲノム学による統合的理解とこれを用いた免疫疾患の発症予防のためのインターベンション戦略の構築","en":"Integrative understanding of human immune system by functional genomics and development of intervention strategies for the prevention of autoimmune diseases"},"summary":{"aims":{"ja":"免疫細胞における遺伝子発現制御と免疫疾患に対する寄与を解明する","en":"To elucidate the regulation of gene expression in each immune cell subset and its contribution to autoimmune diseases."},"methods":{"ja":"全身性強皮症21症例、対照健常者13名の末梢血免疫細胞画分を分取し各画分から抽出したtotal RNAを用いたRNA-seqを実施した。","en":"Various immune cell subsets from 21 systemic sclerosis patients and 13 healthy controls were collected (Naive_B, SM_B, USM_B, DN_B, Plasmablast, Th1, Th2, Th17, Tfh, Naive_CD4, Mem_CD4, Fr._II_eTreg, Naive_CD8, Mem_CD8, mDC, pDC, CD16p_Mono, CD16n_Mono, NK) and total RNAs were extracted from each subset. RNA-seq was performed for each sample."},"targets":{"ja":"全身性強皮症、対照健常者","en":"Systemic sclerosis, healthy individuals"},"url":{"ja":[{"url":"https://ryumachi.umin.jp/","text":"https://ryumachi.umin.jp/"}],"en":[{"url":"https://www.h.u-tokyo.ac.jp/english/centers-services/clinical-divisions/allergy-and-rheumatology/index.html","text":"https://www.h.u-tokyo.ac.jp/english/centers-services/clinical-divisions/allergy-and-rheumatology/index.html"}]}},"listingSummary":{},"releaseNote":{"ja":"全身性強皮症21症例、対照健常者13名の末梢血免疫細胞の様々な画分を分取し、各画分から抽出したRNAを用いたRNA-seqを実施した。解析した際の各遺伝子にマップされたリード数を提供する（txt）。","en":"RNAs extracted from various immune cell subsets of 21 systemic sclerosis patients and 13 healthy controls were collected. RNA-seq was performed for each sample. Read count data mapped to each gene are provided as txt files."},"dataProviders":[{"name":{"ja":"藤尾 圭志","en":"Keishi Fujio"},"organization":{"name":{"ja":"東京大学大学院 医学系研究科 アレルギー・リウマチ学","en":"Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo"}}}],"researchProjects":[{"name":{"ja":"免疫疾患の免疫細胞マルチオミクス解析","en":"Immune cell multi-omics analysis of immune-mediated diseases"},"url":{"ja":[{"url":"https://ryumachi.umin.jp/","text":"https://ryumachi.umin.jp/"}],"en":[{"url":"https://www.h.u-tokyo.ac.jp/english/centers-services/clinical-divisions/allergy-and-rheumatology/index.html","text":"https://www.h.u-tokyo.ac.jp/english/centers-services/clinical-divisions/allergy-and-rheumatology/index.html"}]}}],"grants":[{"title":{"ja":null,"en":null},"agency":{"ja":"中外製薬株式会社との共同研究費","en":"Collaborative research fund with Chugai Pharmaceutical Co., Ltd."},"grantIds":null}],"relatedPublications":[{"title":"Integrated bulk and single-cell RNA-sequencing identified disease-relevant monocytes and a gene network module underlying systemic sclerosis","doi":"https://doi.org/10.1016/j.jaut.2020.102547","datasets":["JGAD000309","E-GEAD-344"]}],"datasets":["JGAD000309"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000309","JGAD000310","JGAD000371","JGAD000372","JGAD000373","JGAD000406","JGAD000602","JGAD000603","JGAD000727","JGAD000755","JGAD000756","JGAD000778"]},{"principalInvestigator":{"en":"Ana Rita Grosso"},"affiliation":{"en":"Computational Multi-Omics Lab, Department of Life Sciences, Universidade Nova de Lisboa - NOVA School of Science and 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University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"ImmuNexUTによるSLE症状と遺伝子発現多様性解析","en":"Linking SLE Symptoms to Gene Expression Variation through ImmuNexUT"},"periodStart":"2025-10-27","periodEnd":"2026-04-02","datasets":["JGAD000603"]}]}