{"id":"hum0203","version":1,"url":"https://humandbs.dbcls.jp/research/hum0203/v1","datePublished":"2020-06-01","versions":[{"version":1,"datePublished":"2020-06-01"}],"title":{"ja":"造血器腫瘍における臨床ゲノム情報統合データベースの構築に関する研究","en":"Establishment of an integrated database for clinical and genomic data in cancer"},"summary":{"aims":{"ja":"網羅的ゲノム解析により日本人多発性骨髄腫のゲノムプロファイルを明らかにする","en":"To clarify the genomic feature of Japanese multiple myeloma (MM) patients by comprehensive genetic analyses"},"methods":{"ja":"Targeted capture sequencing","en":"Targeted capture sequencing"},"targets":{"ja":"日本人多発性骨髄腫154症例（原発巣154検体、再発巣6検体、正常末梢血単核球23検体：計183検体）","en":"Japanese MM"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"多発性骨髄腫：154症例\n（日本人）","en":"154 patients with multiple myeloma\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Target Capture）","en":"NGS\n(Target Capture)"}},"releaseNote":{"ja":"多発性骨髄腫154症例の腫瘍組織（骨髄穿刺にて採取した骨髄液をCD138にてソートした凍結骨髄細胞）および正常として末梢血単核球細胞より抽出したDNAを用いたTarget Capture Sequencing（340遺伝子＋免疫グロブリン再構成領域 [IGH, IGK, IGL]）解析結果をfastqファイルおよびvcfファイルにて提供する。","en":"DNAs extracted from frozen bone marrow CD138 positive cells isolated from bone marrow aspirates or peripheral blood mononuclear cells of 154 patients with multiple myeloma were used for a target capture sequencing analysis (340 genes + immunoglobulin variable regions ([IGH, IGK, IGL]). Fastq files and vcf files are provided."},"dataProviders":[{"name":{"ja":"堀部 敬三","en":"Keizo Horibe"},"organization":{"name":{"ja":"名古屋医療センター・臨床研究センター","en":"Clinical Researc Center, Nagoya Medical Center"}}}],"researchProjects":[{"name":{"ja":"臨床ゲノム情報統合データベース整備事業","en":"Program for an Integrated Database of Clinical and Genomic Information"},"url":{"ja":[{"url":"https://www.amed.go.jp/program/list/14/05/006.html","text":"https://www.amed.go.jp/program/list/14/05/006.html"}],"en":[{"url":"https://www.amed.go.jp/en/program/list/14/05/006.html","text":"https://www.amed.go.jp/en/program/list/14/05/006.html"}]}}],"grants":[{"title":{"ja":"がん領域における臨床ゲノム情報データストレージの整備に関する研究","en":"Establishment of an integrated database for clinical and genomic data in cancer"},"agency":{"ja":"日本医療研究開発機構（AMED） 臨床ゲノム情報統合データベース整備事業","en":"Program for an Integrated Database of Clinical and Genomic Information, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP16kk0205005"]}],"relatedPublications":[{"title":"Genomic analysis of multiple myeloma using targeted capture sequencing in the Japanese cohort","doi":"https://doi.org/10.1111/bjh.16720","datasets":["JGAD000291"]}],"datasets":["JGAD000291"],"controlledAccessUsers":[]}