{"id":"hum0200","secondaryIds":[],"version":1,"url":"https://humandbs.dbcls.jp/research/hum0200/v1","datePublished":"2021-03-29","versions":[{"version":1,"datePublished":"2021-03-29"},{"version":2,"datePublished":"2021-05-07"},{"version":3,"datePublished":"2021-10-01"},{"version":4,"datePublished":"2022-03-02"},{"version":5,"datePublished":"2022-08-29"},{"version":6,"datePublished":"2024-11-25"},{"version":7,"datePublished":"2026-02-04"}],"title":{"ja":"乳腺腫瘍の表現型にかかわる体細胞変異および遺伝子発現異常の解析","en":"Analysis of somatic mutations and gene expression abnormalities involved in mammary tumor phenotype"},"summary":{"aims":{"ja":"非浸潤性乳管がんの分子生物学的背景に基づいたリスク層別化因子の探索","en":"Search for risk stratification factors based on the molecular biological background of non-invasive ductal carcinoma"},"methods":{"ja":"臨床的リスク因子に基づいて非浸潤性乳管がん症例を選択し、網羅的遺伝子解析によりリスク因子との関連を検討する","en":"Select DCIS cases based on clinical risk factors. Examine association with risk factors by comprehensive gene analysis."},"targets":{"ja":"ヒト非浸潤性乳管がん","en":"Human Ductal Carcinoma In Situ (DCIS)"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"非浸潤性乳管がんの腫瘍組織および非腫瘍組織から抽出したDNAを用いたWhole Exome Sequencing解析、および腫瘍組織のシングルセルCNV解析の結果をfastqファイルにて提供する。","en":"DNAs extracted from tumor and non-tumor tissues of 25 Ductal Carcinoma In Situ (DCIS) patients were used for the whole exome sequencing and single-cells from tumor tissues of 2 DCIS patients were used for single-cell CNV analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"永澤 慧","en":"Satoi Nagasawa"},"organization":{"name":{"ja":"聖マリアンナ医科大学 外科学 乳腺・内分泌外科","en":"Division of Breast and Endocrine Surgery, Department of Surgery St. Marianna University School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"先進ゲノム解析研究推進プラットフォーム","en":"Platform for Advanced Genome Science"},"agency":{"ja":"科学研究費助成事業 新学術領域研究（研究領域提案型）","en":"KAKENHI Grant-in-Aid for Scientific Research on Priority Areas (Research in a proposed research area)"},"grantIds":["16H06279"]},{"title":{"ja":"乳房非浸潤性乳管癌(DCIS)の治療最適化に向けた新規再発リスク因子の検討","en":"Investigation of novel risk factors for recurrence to optimize the treatment of ductal carcinoma in situ (DCIS) of the breast"},"agency":{"ja":"日本学術振興会藤田記念医学研究振興基金","en":"JSPS Fujita Memorial Fund for Medical Research"},"grantIds":null}],"relatedPublications":[],"datasets":["JGAD000287"],"controlledAccessUsers":[]}