{"id":"hum0197","secondaryIds":[],"version":7,"url":"https://humandbs.dbcls.jp/research/hum0197/v7","datePublished":"2022-05-23","versions":[{"version":1,"datePublished":"2019-11-15"},{"version":2,"datePublished":"2020-11-27"},{"version":3,"datePublished":"2021-03-22"},{"version":4,"datePublished":"2021-12-10"},{"version":5,"datePublished":"2021-12-21"},{"version":6,"datePublished":"2022-02-08"},{"version":7,"datePublished":"2022-05-23"},{"version":8,"datePublished":"2022-06-03"},{"version":9,"datePublished":"2022-06-10"},{"version":10,"datePublished":"2022-06-16"},{"version":11,"datePublished":"2022-07-21"},{"version":12,"datePublished":"2022-12-01"},{"version":13,"datePublished":"2023-02-14"},{"version":14,"datePublished":"2023-02-16"},{"version":15,"datePublished":"2023-03-29"},{"version":16,"datePublished":"2023-06-06"},{"version":17,"datePublished":"2023-06-27"},{"version":18,"datePublished":"2023-10-02"},{"version":19,"datePublished":"2024-05-29"},{"version":20,"datePublished":"2024-05-30"},{"version":21,"datePublished":"2024-10-28"},{"version":22,"datePublished":"2024-11-11"},{"version":23,"datePublished":"2024-12-18"},{"version":24,"datePublished":"2025-05-07"},{"version":25,"datePublished":"2025-07-25"},{"version":26,"datePublished":"2025-10-27"},{"version":27,"datePublished":"2025-12-02"},{"version":28,"datePublished":"2025-12-12"},{"version":29,"datePublished":"2026-01-22"},{"version":30,"datePublished":"2026-03-10"},{"version":31,"datePublished":"2026-07-31"}],"title":{"ja":"多層的オミクス解析による疾患病態の解明","en":"Elucidation of disease state by multi-layered omics analysis"},"summary":{"aims":{"ja":"多層的オミクス解析による疾患病態の解明、日本人集団におけるGWASおよび複数集団におけるGWASメタ解析","en":"Elucidation of disease biology based on trans-omics analysis, GWAS in the Japanese and trans-ethnic populations"},"methods":{"ja":"メタゲノムシークエンス、ゲノムワイド関連解析、small RNA-seq解析、eQTL解析","en":"Metagenome shotgun sequencing, genome-wide association study (GWAS), small RNA-seq and eQTL analyses"},"targets":{"ja":"日本人集団（95＋103＋227＋30名）の腸内細菌叢のメタゲノムシークエンスデータ\n肺胞蛋白症患者：198名、対照者：395名のゲノムワイド関連解析データ\nバイオバンク・ジャパン（179,000名）、UKバイオバンク（361,000名）、FinnGen（136,000名）の215形質のゲノムワイド関連解析データ\n日本人集団141名のsmall RNA-seq解析により定量した個人毎のmiRNAリードカウントデータと、全ゲノムシーケンス解析データと合わせて解析したeQTL解析データ\n炎症性腸疾患症例（潰瘍性大腸炎35症例、クローン病39症例）、対照健常者40名のメタゲノムシークエンスデータ","en":"Metagenomic data of gut microbiome in the Japanese population (95 + 103 + 227 + 30 individuals)\nAutoimmune pulmonary alveolar proteinosis cases: 198, Control participants: 395\nPopulations: Biobank Japan (n = 179,000), UK biobank (n = 361,000), ans FinnGen (n = 136,000), Phenotypes: 215\n141 Japanese individuals\nMetagenomic data of gut microbiome in Inflammatory Bowel Disease (35 Ulcerative Colitis and 39 Crohn's disease) and 40 Healthy controls"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"潰瘍性大腸炎35症例、クローン病39症例、対照健常者40名の便より抽出したDNAを用いた、全ゲノムショットガンシークエンスによるメタゲノム関連解析データを提供する（fastq）。","en":"A metagenome-wide association study of gut microbiome in Inflammatory Bowel Disease (35 Ulcerative Colitis and 39 Crohn's disease) and 40 Healthy controls was performed by utilizing whole-genome shotgun sequencing. Fastq files are provided."},"dataProviders":[{"name":{"ja":"岡田 随象","en":"Yukinori Okada"},"organization":{"name":{"ja":"大阪大学大学院 医学系研究科 遺伝統計学","en":"Department of Statistical Genetics, Osaka University Graduate School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"遺伝統計学が紐解く微生物叢・宿主・疾患・創薬のクロストーク","en":"Crosstalk among microbiome, host, disease, and drug discovery enhanced by statistical genetics"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的先端研究開発支援事業 ソロタイプ（PRIME）","en":"Precursory Research for Innovative Medical care (PRIME), Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP19gm6010001"]},{"title":{"ja":"メタゲノムワイド関連解析による疾患特異的微生物叢解明と個別化医療実装","en":"Elucidation of disease-specific microbiota and personalized medicine by metagenome-wide association studies"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的先端研究開発支援事業 ステップタイプ（FORCE）","en":"FORCE, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP20gm4010006"]},{"title":{"ja":"横断的オミクス解析を駆使した肺胞蛋白症の病態解明とインシリコ・リポジショニング創薬","en":"Biology and in silico drug repositioning of pulmonary alveolar proteinosis using trans-layer omics analysis"},"agency":{"ja":"日本医療研究開発機構（AMED） 難治性疾患実用化研究事業","en":"Practical Research Project for Rare / Intractable Diseases, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP20ek0109413"]},{"title":{"ja":"疾患ゲノム情報を活用した自己免疫疾患における核酸ゲノム創薬の推進","en":"Nucleic genome drug discovery for autoimmune diseases through in-silico and patient-oriented screening utilizing large-scale disease genetics"},"agency":{"ja":"日本医療研究開発機構（AMED） 免疫アレルギー疾患実用化研究事業","en":"Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP19ek0410041"]},{"title":{"ja":"免疫オミクス情報の横断的統合による関節リウマチのゲノム個別化医療の実現","en":"Genomic prediction medicine of rheumatoid arthritis based on comprehensive immune-omics resources"},"agency":{"ja":"日本医療研究開発機構（AMED） 免疫アレルギー疾患実用化研究事業","en":"Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP21ek0410075"]},{"title":{"ja":"遺伝統計学に基づく日本人集団のゲノム個別化医療の実装","en":"Implementation of genomic prediction medicine based on statistical genetics"},"agency":{"ja":"日本医療研究開発機構（AMED） ゲノム医療実現推進プラットフォーム事業","en":"Platform Program for Promotion of Genome Medicine, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP21km0405211"]},{"title":{"ja":"次世代ゲノミクス研究による乾癬の疾患病態解明・個別化医療・創薬","en":"Next-generation genomics analyses elucidates biology, personalized medicine, and drug discovery of psoriasis"},"agency":{"ja":"日本医療研究開発機構（AMED） ゲノム医療実現推進プラットフォーム事業","en":"Platform Program for Promotion of Genome Medicine, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP21km0405217"]},{"title":{"ja":"横断的オミクス解析と全ゲノムシークエンスを駆使した疾患病態と組織特異性の解明","en":"Elucidation of disease biology and tissue specificity by trans-layer omics analysis and whole-genome sequencing"},"agency":{"ja":"科学研究費助成事業 基盤研究（A）","en":"KAKENHI Grant-in-Aid for Scientific Research (A)"},"grantIds":["19H01021"]}],"relatedPublications":[{"title":"Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population.","doi":"https://doi.org/10.1136/annrheumdis-2019-215743","datasets":["JGAD000290"]},{"title":"Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis.","doi":"https://doi.org/10.1038/s41467-021-21011-y","datasets":["NHA000154"]},{"title":"A metagenome-wide association study of gut microbiome in patients with multiple sclerosis revealed novel disease pathology.","doi":"https://doi.org/10.3389/fcimb.2020.585973","datasets":["JGAD000363"]},{"title":"A global atlas of genetic associations of 220 deep phenotypes","doi":"https://doi.org/10.1038/s41588-021-00931-x","datasets":["NHA000162"]},{"title":"Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese","doi":"https://doi.org/10.1136/annrheumdis-2021-220687","datasets":["JGAD000427"]},{"title":"Whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease","doi":"https://doi.org/10.1136/annrheumdis-2021-221267","datasets":["JGAD000532"]},{"title":"Insights from complex trait fine-mapping across diverse populations","doi":"https://doi.org/10.1101/2021.09.03.21262975","datasets":["NHA000164","NHA000163"]},{"title":"Genetic architecture of microRNA expression and its link to complex diseases in the Japanese population.","doi":"https://doi.org/10.1093/hmg/ddab361","datasets":["JGAD000621","NHA000166"]}],"datasets":["JGAD000290","NHA000154","JGAD000363","NHA000162","JGAD000427","JGAD000532","NHA000164","NHA000163","JGAD000621","NHA000166","JGAD000649"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"Brito Ilana","en":"Ilana Brito"},"affiliation":{"ja":"Meinig School of Biomedical Engineering, Cornell University"},"country":{"ja":"アメリカ合衆国 (ニューヨーク州)","en":"New York, United States"},"researchTitle":{"ja":"Comparative metagenomics of lupus patients' microbiomes","en":"Comparative metagenomics of lupus patients' microbiomes (Protocol Number IRB0144130)"},"periodStart":"2022-05-12","periodEnd":"2025-01-08","datasets":["JGAD000290","JGAD000363","JGAD000427","JGAD000532"]},{"principalInvestigator":{"en":"Yongxin LI"},"affiliation":{"en":"The department of Chemistry, The University of Hong Kong"},"country":{"ja":"中国","en":"China"},"researchTitle":{"en":"Comparison of gut bacterial diversity and composition in MS/EAE"},"periodStart":"2022-09-26","periodEnd":"2025-06-09","datasets":["JGAD000363"]},{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000290","JGAD000363","JGAD000427","JGAD000532","JGAD000621","JGAD000649","JGAD000650","JGAD000662","JGAD000722","JGAD000729","JGAD000876","JGAD000890","JGAD000925","JGAD001005"]},{"principalInvestigator":{"en":"Tina Fuchs"},"affiliation":{"en":"Institute for Clinical Chemistry, Medical Faculty Mannheim, Heidelberg University"},"country":{"ja":"ドイツ","en":"Germany"},"researchTitle":{"en":"Investigating the clonality of VIREM cells in COVID-19 patients"},"periodStart":"2024-02-26","periodEnd":"2025-04-14","datasets":["JGAD000662","JGAD000722"]},{"principalInvestigator":{"ja":"松田 浩一","en":"Koichi Matsuda"},"affiliation":{"ja":"クリニカルシークエンス分野, 東京大学","en":"Clinical genome sequencing, The University of Tokyo"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"疾患コホート研究ネットワークによる疾患マーカー探索研究","en":"Disease Cohort Research Network for Disease Marker Exploratory Studies"},"periodStart":"2024-06-17","periodEnd":"2029-03-31","datasets":["JGAD000290","JGAD000363","JGAD000427","JGAD000532","JGAD000649","JGAD000650","JGAD000662","JGAD000722","JGAD000729"]},{"principalInvestigator":{"ja":"桐田 雄平","en":"Yuhei Kirita"},"affiliation":{"ja":"腎臓内科, 京都府立医科大学","en":"Department of Nephrology, Kyoto Prefectural University of Medicine"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"IgA腎症と免疫関連疾患の末梢血遺伝子発現比較解析による病態解明","en":"Elucidation of the Pathogenesis through Comparative Analysis of Peripheral Blood Gene Expression in IgA Nephropathy and Immune-related Diseases"},"periodStart":"2025-07-29","periodEnd":"2030-03-31","datasets":["JGAD000662","JGAD000722"]}]}