{"id":"hum0197","secondaryIds":[],"version":1,"url":"https://humandbs.dbcls.jp/research/hum0197/v1","datePublished":"2019-11-15","versions":[{"version":1,"datePublished":"2019-11-15"},{"version":2,"datePublished":"2020-11-27"},{"version":3,"datePublished":"2021-03-22"},{"version":4,"datePublished":"2021-12-10"},{"version":5,"datePublished":"2021-12-21"},{"version":6,"datePublished":"2022-02-08"},{"version":7,"datePublished":"2022-05-23"},{"version":8,"datePublished":"2022-06-03"},{"version":9,"datePublished":"2022-06-10"},{"version":10,"datePublished":"2022-06-16"},{"version":11,"datePublished":"2022-07-21"},{"version":12,"datePublished":"2022-12-01"},{"version":13,"datePublished":"2023-02-14"},{"version":14,"datePublished":"2023-02-16"},{"version":15,"datePublished":"2023-03-29"},{"version":16,"datePublished":"2023-06-06"},{"version":17,"datePublished":"2023-06-27"},{"version":18,"datePublished":"2023-10-02"},{"version":19,"datePublished":"2024-05-29"},{"version":20,"datePublished":"2024-05-30"},{"version":21,"datePublished":"2024-10-28"},{"version":22,"datePublished":"2024-11-11"},{"version":23,"datePublished":"2024-12-18"},{"version":24,"datePublished":"2025-05-07"},{"version":25,"datePublished":"2025-07-25"},{"version":26,"datePublished":"2025-10-27"},{"version":27,"datePublished":"2025-12-02"},{"version":28,"datePublished":"2025-12-12"},{"version":29,"datePublished":"2026-01-22"},{"version":30,"datePublished":"2026-03-10"},{"version":31,"datePublished":"2026-07-31"}],"title":{"ja":"多層的オミクス解析による疾患病態の解明","en":"Elucidation of disease state by multi-layered omics analysis"},"summary":{"aims":{"ja":"腸内細菌叢の病原性の解明","en":"Elucidation of gut microbiome's role in human biology"},"methods":{"ja":"全ゲノムショットガンシークエンスを用いたメタゲノム関連解析","en":"A comprehensive metagenome-wide association study by utilizing whole-genome shotgun sequencing"},"targets":{"ja":"日本人集団（95名）の腸内細菌叢のメタゲノムデータ","en":"Metagenomic data of gut microbiome in the Japanese population"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"日本人集団95名の便より抽出したDNAを用いた、全ゲノムショットガンシークエンスによるメタゲノム関連解析データを提供する（fastq）。","en":"A metagenome-wide association study of gut microbiome in the Japanese population was performed by utilizing whole-genome shotgun sequencing. Fastq files are provided."},"dataProviders":[{"name":{"ja":"岡田 随象","en":"Yukinori Okada"},"organization":{"name":{"ja":"大阪大学大学院 医学系研究科 遺伝統計学","en":"Department of Statistical Genetics, Osaka University Graduate School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"遺伝統計学が紐解く微生物叢・宿主・疾患・創薬のクロストーク","en":"Crosstalk among microbiome, host, disease, and drug discovery enhanced by statistical genetics"},"agency":{"ja":"日本医療研究開発機構 革新的先端研究開発支援事業（AMED-PRIME）","en":"Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-PRIME)"},"grantIds":["19gm6010001h0004"]}],"relatedPublications":[{"title":"Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population.","doi":"https://doi.org/10.1136/annrheumdis-2019-215743","datasets":["JGAD000290"]}],"datasets":["JGAD000290"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"Brito Ilana","en":"Ilana Brito"},"affiliation":{"ja":"Meinig School of Biomedical Engineering, Cornell University"},"country":{"ja":"アメリカ合衆国 (ニューヨーク州)","en":"New York, United States"},"researchTitle":{"ja":"Comparative metagenomics of lupus patients' microbiomes","en":"Comparative metagenomics of lupus patients' microbiomes (Protocol Number IRB0144130)"},"periodStart":"2022-05-12","periodEnd":"2025-01-08","datasets":["JGAD000290","JGAD000363","JGAD000427","JGAD000532"]},{"principalInvestigator":{"en":"Yongxin LI"},"affiliation":{"en":"The department of Chemistry, The University of Hong Kong"},"country":{"ja":"中国","en":"China"},"researchTitle":{"en":"Comparison of gut bacterial diversity and composition in MS/EAE"},"periodStart":"2022-09-26","periodEnd":"2025-06-09","datasets":["JGAD000363"]},{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000290","JGAD000363","JGAD000427","JGAD000532","JGAD000621","JGAD000649","JGAD000650","JGAD000662","JGAD000722","JGAD000729","JGAD000876","JGAD000890","JGAD000925","JGAD001005"]},{"principalInvestigator":{"en":"Tina Fuchs"},"affiliation":{"en":"Institute for Clinical Chemistry, Medical Faculty Mannheim, Heidelberg University"},"country":{"ja":"ドイツ","en":"Germany"},"researchTitle":{"en":"Investigating the clonality of VIREM cells in COVID-19 patients"},"periodStart":"2024-02-26","periodEnd":"2025-04-14","datasets":["JGAD000662","JGAD000722"]},{"principalInvestigator":{"ja":"松田 浩一","en":"Koichi Matsuda"},"affiliation":{"ja":"クリニカルシークエンス分野, 東京大学","en":"Clinical genome sequencing, The University of Tokyo"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"疾患コホート研究ネットワークによる疾患マーカー探索研究","en":"Disease Cohort Research Network for Disease Marker Exploratory Studies"},"periodStart":"2024-06-17","periodEnd":"2029-03-31","datasets":["JGAD000290","JGAD000363","JGAD000427","JGAD000532","JGAD000649","JGAD000650","JGAD000662","JGAD000722","JGAD000729"]},{"principalInvestigator":{"ja":"桐田 雄平","en":"Yuhei Kirita"},"affiliation":{"ja":"腎臓内科, 京都府立医科大学","en":"Department of Nephrology, Kyoto Prefectural University of Medicine"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"IgA腎症と免疫関連疾患の末梢血遺伝子発現比較解析による病態解明","en":"Elucidation of the Pathogenesis through Comparative Analysis of Peripheral Blood Gene Expression in IgA Nephropathy and Immune-related Diseases"},"periodStart":"2025-07-29","periodEnd":"2030-03-31","datasets":["JGAD000662","JGAD000722"]}]}