{"id":"hum0196","version":1,"url":"https://humandbs.dbcls.jp/research/hum0196/v1","datePublished":"2019-12-20","versions":[{"version":1,"datePublished":"2019-12-20"}],"title":{"ja":"自殺者血液および死後脳標本を用いた自殺に関連した生物学的マーカーの同定と自殺予防への応用に関する研究","en":"Identification of biomarker for suicide prevention using blood and brain samples of completed suicide"},"summary":{"aims":{"ja":"自殺リスクに関するバイオマーカーの同定と、その臨床応用","en":"Identification of biomarkers for risk of suicide and application to clinical use"},"methods":{"ja":"自殺者と非自殺者の網羅的遺伝子多型データを用いたゲノムワイド関連解析","en":"GWAS"},"targets":{"ja":"自殺者746名、非自殺者14,049名（バイオバンクジャパンのデータ）","en":"Individuals who died by suicide"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"ゲノムワイド関連","en":"GWAS"},"targets":{"ja":"自殺者：746名\n非自殺者：14,049名\n（日本人）","en":"Suicide: 746 cases\nNon-suicide: 14,049 cases\n(Japanese)"},"typeOfData":{"ja":"SNP-chip","en":"SNP-chip"}},"releaseNote":{"ja":"自殺者746名および非自殺者14,049名を対象とし、自殺者と非自殺者、および自殺時の年齢についてのGWASメタ解析を行なった結果をtxt fileにて提供する。遺伝子型決定には、Illumina HumanOmniExpress-24 BeadChipおよびHumanOmniExpressExome-8 BeadChipを使用している。","en":"Result of meta analyses of the case-control GWAS datasets for suicides vs. non-suicide individuals and for age at suicide (txt file). Genotypes were determined by using of Illumina HumanOmniExpress-24 BeadChip and HumanOmniExpressExome-8 BeadChip."},"dataProviders":[{"name":{"ja":"菱本 明豊","en":"Akitoyo Hishimoto"},"organization":{"name":{"ja":"神戸大学大学院 医学研究科 精神医学分野","en":"Department of Psychiatry, Kobe University Graduate School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"ストレス・うつ・自殺ー負のスパイラルを結ぶ分子機構の解明","en":"Investigation on molecular mechanism causing the downward spiral of Stress, Depression, and Suicide"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["17H04249"]}],"relatedPublications":[{"title":"Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population","doi":"https://doi.org/10.1038/s41386-019-0506-5","datasets":["NHA000131"]}],"datasets":["NHA000131"],"controlledAccessUsers":[]}