{"id":"hum0191","version":1,"url":"https://humandbs.dbcls.jp/research/hum0191/v1","datePublished":"2020-06-05","versions":[{"version":1,"datePublished":"2020-06-05"}],"title":{"ja":"個々のがんの遺伝子変異に基づく固有抗原の同定と腫瘍内微小環境の解析に基づく免疫制御法を組み合わせた個別化がんワクチン治療の開発","en":"Development of personalized cancer vaccine targeting individual somatic mutations combined with immunoregulation of tumor microenvironment"},"summary":{"aims":{"ja":"膵がん症例の腫瘍組織を用いて膵がん発症者の免疫状態をモニタリングし、予後との関連を検討する","en":"To explore prognostic biomarkers using RNAseq data from tumor tissues of resected pancreatic cancer patients"},"methods":{"ja":"膵がん（腫瘍組織）から抽出したRNAを用いたRNA-Seq解析データを用いた発現解析および腫瘍浸潤リンパ球予測","en":"Analyses of gene expression and lymphocyte enrichment in the tumor tissues by using of RNA-seq data"},"targets":{"ja":"根治手術実施後の膵がん症例","en":"Patients with pancreatic cancer who underwent curative surgery"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"膵癌：17症例\n（日本人）","en":"Pancreatic cancer: 17 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"膵がん17症例の腫瘍組織から抽出したRNAを用いたRNA-Seq解析データをfastqファイルにて提供する。","en":"RNAs extracted from tumor tissues of 17 pancreatic cancer patients were used for the RNA sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"垣見 和宏","en":"Kazuhiro Kakimi"},"organization":{"name":{"ja":"東京大学医学部附属病院 免疫細胞治療学講座","en":"Department of Immunotherapeutics, The University of Tokyo Hospital"}}}],"researchProjects":[],"grants":[{"title":{"ja":"エピジェネティクスと免疫制御の併用によるネオアンチゲンを標的としたがん免疫治療","en":"Novel cancer immunotherapy targeting neoantigens in combination with epigenetics and immune modulatio"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["16H04708"]},{"title":{"ja":"遺伝子変異由来ネオエピトープを標的としたがん免疫治療の開発","en":"Development of cancer immunotherapy targeting mutation-derived neoantigens"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["16K07162"]}],"relatedPublications":[{"title":"NK cell and IFN signatures are positive prognostic biomarkers for resectable pancreatic cancer","doi":"https://doi.org/10.1016/j.bbrc.2017.12.083","datasets":["DRA008575"]}],"datasets":["DRA008575"],"controlledAccessUsers":[]}