{"id":"hum0187","version":1,"url":"https://humandbs.dbcls.jp/research/hum0187/v1","datePublished":"2020-05-12","versions":[{"version":1,"datePublished":"2020-05-12"},{"version":2,"datePublished":"2021-05-31"}],"title":{"ja":"消化器癌のゲノム・遺伝子解析とその臨床病理学的意義の解明","en":"Genomic and genetic analysis of digestive tract cancer and elucidation of its clinicopathological significance."},"summary":{"aims":{"ja":"肝細胞がんゲノムへのウイルスゲノム挿入部位解析","en":"Impact of viral integration into the host genome on development of hepatocellular carcinoma"},"methods":{"ja":"ウイルスキャプチャーシーケンス（NGS）、Exome（NGS）、RNA-seq（NGS）、DNA_methylation（Infinium450K）","en":"Virus capture sequencing (NGS), Exome (NGS), RNA-seq (NGS), DNA_methylation (Infinium450K)"},"targets":{"ja":"肝細胞がん 243＋160症例","en":"hepatocellular carcinoma"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"肝細胞がん243症例の腫瘍組織および59症例の非腫瘍組織（腫瘍組織の周辺組織）から抽出したgDNAを用いたウイルスゲノム挿入部位（ウイルスキャプチャーシークエンシング）解析結果をfastqファイルにて提供する。","en":"gDNAs extracted from tumor and non-tumor tissues of hepatocellular carcinoma patients were used for a virus capture sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"油谷 浩幸","en":"Hiroyuki Aburatani"},"organization":{"name":{"ja":"東京大学先端科学技術研究センター","en":"RCAST, the University of Tokyo"}}}],"researchProjects":[{"name":{"ja":"ゲノムサイエンス分野","en":"Genome Science laboratory"},"url":{"ja":[{"url":"https://www.genome.rcast.u-tokyo.ac.jp/ja/research","text":"https://www.genome.rcast.u-tokyo.ac.jp/ja/research"}],"en":[{"url":"https://www.genome.rcast.u-tokyo.ac.jp/en/research","text":"https://www.genome.rcast.u-tokyo.ac.jp/en/research"}]}}],"grants":[{"title":{"ja":"肝臓癌の術後生存率を高め、医療費低減を可能とする人工知能・質量分析診断支援装置の治験","en":"Clinical trial of cancer diagnosis assisting machine based on the mass spectrometry and artificial intelligence: Towards improving the survival rate of hepatic tumor and reducing medical expense"},"agency":{"ja":"日本医療研究開発機構（AMED） 医療機器開発推進研究事業","en":"Research on Development of New Medical Devices, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP19hk0102049"]},{"title":{"ja":"国際共同研究に資する日本人難治性がん・生活習慣病関連がん大規模統合ゲノミクス解析と国際コンソーシアムでのデータ共有による国際貢献","en":"Large-scale integrated genomic analysis of Japanese intractable and life-style related cancers as an international contribution to ICGC and WHO-lead collaborative researches towards precision cancer treatment and prevention"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP19ck0106265"]},{"title":{"ja":"ウイルス性肝疾患を含む代謝関連肝がん発生の病態解明に関する研究","en":"Study on the pathogenesis of metabolism-associated liver cancer including those associated with viral hepatitis"},"agency":{"ja":"日本医療研究開発機構（AMED） 肝炎等克服緊急対策研究事業","en":"Research Program on Hepatitis, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP19fk0210040"]},{"title":{"ja":"がんゲノム解析で残された微小コピー数変化の検出とその意義の解明","en":"Focal copy number alteration and its functional role in carcinogenesis: unmet needs in cancer genome analysis"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["17K07195"]}],"relatedPublications":[{"title":"Impact of AAV2 and Hepatitis B Virus Integration Into Genome on Development of Hepatocellular Carcinoma in Patients with Prior Hepatitis B Virus Infection","doi":"https://doi.org/10.1158/1078-0432.CCR-18-4041","datasets":["JGAD000277"]},{"title":"Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression","doi":"https://doi.org/10.1158/0008-5472.CAN-20-0225","datasets":["JGAD000328","JGAD000329","JGAD000330"]}],"datasets":["JGAD000277"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"河野 隆志","en":"Takashi Kohno"},"affiliation":{"ja":"ゲノム生物学研究分野, 国立研究開発法人国立がん研究センター研究所","en":"Division of Genome Biology, National Cancer Center Research Institute"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"AYA(Adolescence and Young Adult)世代がんの個別化予防に資する遺伝要因の同定を目指す研究","en":"Identification of genetic risk factors in AYA(Adolescence and Young Adult) cancer"},"periodStart":"2021-12-02","periodEnd":"2028-12-31","datasets":["JGAD000277","JGAD000328","JGAD000329","JGAD000330"]},{"principalInvestigator":{"en":"Jinyan Huang"},"affiliation":{"en":"Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China. Biomedical big data center, the First Affiliated Hospital, Zhejiang University"},"country":{"ja":"中国","en":"China"},"researchTitle":{"en":"Comprehensive analysis of alternative splicing in malignant tumors"},"periodStart":"2022-03-15","periodEnd":"2024-01-01","datasets":["JGAD000277","JGAD000328","JGAD000329"]},{"principalInvestigator":{"en":"Jian Cao"},"affiliation":{"en":"Jian Cao Lab, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey"},"country":{"ja":"アメリカ合衆国 (ニュージャージー州)","en":"New Jersey, United States"},"researchTitle":{"en":"Analyzing oncovirus in NBDC tumor sequencing data"},"periodStart":"2023-01-12","periodEnd":"2026-03-12","datasets":["JGAD000277","JGAD000328","JGAD000329","JGAD000330"]},{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000329"]}]}