{"id":"hum0176","version":1,"url":"https://humandbs.dbcls.jp/research/hum0176/v1","datePublished":"2019-10-02","versions":[{"version":1,"datePublished":"2019-10-02"}],"title":{"ja":"子宮及び卵巣がん肉腫におけるドライバー変異の体系的探索","en":"Comprehensive sequencing analyses of uterine and ovarian carcinosarcoma"},"summary":{"aims":{"ja":"子宮及び卵巣がん肉腫におけるドライバー変異の体系的探索","en":"Comprehensive sequencing analyses of uterine and ovarian carcinosarcoma"},"methods":{"ja":"Illumina HiSeq 2000を使用した Exome / Target Capture解析","en":"Exome / target caputer analysis by using Illumina Hiseq 2000"},"targets":{"ja":"子宮がん肉腫92症例、卵巣がん肉腫17症例の正常組織（非腫瘍組織）と原発巣の腫瘍組織","en":"109 primary tumor and mached normal (non-tumor) tissues from uterin or ovarian carcinosarcoma patients"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"子宮癌肉腫：92症例\n卵巣癌肉腫：17症例\n（日本人）","en":"92 uterine carcinosarcomas\n17 ovarian carcinosarcomas\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome、Target Capture）","en":"NGS\n(Exome, Target Capture)"}},"releaseNote":{"ja":"子宮がん肉腫92症例（184検体）、卵巣がん肉腫17症例（34検体）の正常組織（非腫瘍組織）と原発巣の腫瘍組織から抽出したDNAを用いたExome解析およびTarget Capture解析結果をfastqファイルにて提供する。","en":"DNAs extracted from primary tumor and mached normal (non-tumor) tissues of uterin and ovarian carcinosarcoma were used for the whole exome sequencing analysis and target capture sequencing analysis (fastq files)."},"dataProviders":[{"name":{"ja":"森 誠一","en":"Seiichi Mori"},"organization":{"name":{"ja":"がんプレシジョン医療研究センター","en":"Cancer Precison Medicine Center"}}}],"researchProjects":[],"grants":[{"title":{"ja":"類内膜腺癌の個別化医療を目指したゲノムワイドな原因遺伝子・分子標的探索","en":"Genome-wide analyses of endometrial endometrioid carcinoma for early detection and personalized medicine."},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["26462543"]},{"title":{"ja":"1細胞発現解析による悪性腹水貯留の分子機序の解明","en":"Molecular analysis of malignant ascites formation by single-cell RNA-sequencing."},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["15K06861"]},{"title":{"ja":"子宮体癌時系列検体を用いた黄体ホルモン治療抵抗性・再発を規定する遺伝子変異の同定","en":"Identification of the progestin therapy resistance genes in time-course endometrial cancer samples."},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["17K11308"]},{"title":{"ja":"全ゲノムシーケンス解析による癌肉腫の責任遺伝子同定","en":"Whole genome sequencing analyses of uterine and ovarian carcinosarcoma."},"agency":{"ja":"科学研究費助成事業 若手研究（B）","en":"KAKENHI Grant-in-Aid for Young Scientists (B)"},"grantIds":["17K18337"]},{"title":{"ja":"子宮・卵巣癌肉腫の悪性度・予後に寄与するがん免疫微小環境の解析","en":"Immune microenvironment analyses of uterine and ovarian carcinosarcoma."},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["18K07338"]},{"title":{"ja":"再発性および治療抵抗性卵巣がんに関与する変異遺伝子群の探索","en":"Exploration of relevant mutations associated with relapsing or refractory ovarian cancer."},"agency":{"ja":"車両競技公益資金記念財団助成金 がんの基礎的、先駆的研究 助成事業","en":"The Vehicle Racing Commemorative Foundation"},"grantIds":["5144","5274","5393"]}],"relatedPublications":[],"datasets":["JGAD000250"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"万代 昌紀","en":"Masaki Mandai"},"affiliation":{"ja":"婦人科学産科学教室, 京都大学医学部医学研究科","en":"department of Gynecology and Obstetrics, Kyoto University Faculty of Medicene"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"多様な臨床情報を考慮した婦人科悪性腫瘍患者のオミックス解析（全ゲノム・全トランスクリプトーム・プロテオーム・メタボローム解析）による個別化治療の探索","en":"Integrated analyses of omics (genomics, transcriptomics, proteomics and metabolomics) associated with clinical variables for developing indivisualizedtreatment in gynecological malignancy"},"periodStart":"2018-10-04","periodEnd":"2025-04-14","datasets":["JGAD000250"]},{"principalInvestigator":{"ja":"白石 航也","en":"Kouya Shiraishi"},"affiliation":{"ja":"ゲノム生物学研究分野, 国立研究開発法人国立がん研究センター研究所","en":"Division of Genome Biology, National Cancer Research Institute"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"ゲノム解析に基づく宿主並びに腫瘍における免疫応答ネットワーク機構の解明","en":"Elucidation of immune-system networks between host and tumor based on genomic analysis"},"periodStart":"2019-08-05","periodEnd":"2029-03-31","datasets":["JGAD000250"]},{"principalInvestigator":{"ja":"松村 謙臣","en":"Noriomi Matsumura"},"affiliation":{"ja":"産科婦人科学教室, 近畿大学医学部","en":"Obstetrics and Gynecology, Kindai University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"JGOG3017-TR1：エクソームシークエンスデータを有する卵巣明細胞癌のRNAseq解析","en":"Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1"},"periodStart":"2024-10-15","periodEnd":"2027-12-31","datasets":["JGAD000250"]},{"principalInvestigator":{"ja":"山口 建","en":"Ken Yamaguchi"},"affiliation":{"ja":"婦人科学産婦人科学教室, 京都大学","en":"Gynecology and Obstetrics, Kyoto University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"JGOG3017-TR1：エクソームシークエンスデータを有する卵巣明細胞癌のRNAseq解析","en":"Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1"},"periodStart":"2024-10-22","periodEnd":"2027-12-31","datasets":["JGAD000250"]}]}