{"id":"hum0173","version":1,"url":"https://humandbs.dbcls.jp/research/hum0173/v1","datePublished":"2019-04-23","versions":[{"version":1,"datePublished":"2019-04-23"}],"title":{"ja":"胎児期に始まる子どもの健康と発達に関する調査","en":"A Study on the Health and Development of Children Beginning in the Fetal Period"},"summary":{"aims":{"ja":"遺伝要因および環境要因が子どもの健康に与える影響の探索。 胎内および出生後の健康状態と環境要因を調査し、疾患に関連するエピゲノム変化の同定、腸内細菌叢の解析、疾患の予測バイオマーカーの確立を通して、慢性疾患リスク低減に役立つような早期の予防的介入方法を探索し、次世代の健康増進に役立てる。","en":"to explore the effects of genetic and environmental factors, particularly the fetal environment and post-birth living environment, on children's health and to identify potential biomarkers for these effects."},"methods":{"ja":"Reduced Representation Bisulfite Sequencing（RRBS）","en":"Reduced Representation Bisulfite Sequencing (RRBS)"},"targets":{"ja":"臍帯組織（正常分娩）","en":"human umbilical cords"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"メチル化","en":"Methylation profiling"},"targets":{"ja":"臍帯組織（正常出産）：30検体\n（日本人）","en":"human umbilical cords: 30 samples\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RRBS）","en":"NGS\n(RRBS)"}},"releaseNote":{"ja":"正常分娩の臍帯組織から抽出したDNAを用いたReduced Representation Bisulfite Sequencing（RRBS）データ（bam）を提供する。","en":"DNAs extracted from human umbilical cords were used for Reduced Representation Bisulfite Sequencing (RRBS). Bam files were provided."},"dataProviders":[{"name":{"ja":"森 千里","en":"Chisato Mori"},"organization":{"name":{"ja":"千葉大学・予防医学センター","en":"Chiba University・Center for Preventive Medical Sciences"}}}],"researchProjects":[{"name":{"ja":"Chiba Study of Mother and Child Health (C-MACH)","en":"Chiba Study of Mother and Child Health (C-MACH)"},"url":{"ja":[{"url":"https://cpms.chiba-u.jp/kids/","text":"https://cpms.chiba-u.jp/kids/"}],"en":null}}],"grants":[{"title":{"ja":"マルチオミクス指標を用いた児の健康影響評価法と胎児期からの新しい予防医学の確立","en":"Establishment of new preventive medicine focusing on fetal period with children's health effect evaluation method by using multi-omics analysis"},"agency":{"ja":"科学研究費助成事業 基盤研究（A）","en":"KAKENHI Grant-in-Aid for Scientific Research (A)"},"grantIds":["16H01781"]}],"relatedPublications":[{"title":"Chiba study of Mother and Children's Health (C-MACH): cohort study with omics analyses.","doi":"https://doi.org/10.1136/bmjopen-2015-010531","datasets":["JGAD000249"]},{"title":"DNA methylome of human neonatal umbilical cord: Enrichment of differentially methylated regions compared to umbilical cord blood DNA at transcription factor genes involved in body patterning and effects of maternal folate deficiency or children's sex.","doi":"https://doi.org/10.1371/journal.pone.0214307","datasets":["JGAD000249"]}],"datasets":["JGAD000249"],"controlledAccessUsers":[]}