{"id":"hum0169","version":1,"url":"https://humandbs.dbcls.jp/research/hum0169/v1","datePublished":"2019-06-01","versions":[{"version":1,"datePublished":"2019-06-01"},{"version":2,"datePublished":"2020-07-17"}],"title":{"ja":"脳脊髄腫瘍のバイオマーカーの探索と標的治療開発に向けた遺伝子解析及びヒト由来脳脊髄腫瘍細胞株を用いた前臨床研究","en":"Molecular analysis to identify novel biomarker and therapeutic target for cerebrospinal tumor and preclinical investigation using patient derived orthotopic xenograft models."},"summary":{"aims":{"ja":"遺伝子解析により、ヒト由来中枢神経原発悪性リンパ腫の細胞株と、細胞株を樹立する際に用いた中枢神経原発悪性リンパ腫を持つ患者の腫瘍組織を比較する","en":"to compare genomic alterations between tumor tissues from Primary Central Nervous System Lymphoma (PCNSL) patients and xenograft samples derived from PCNSL patients"},"methods":{"ja":"全エキソン解析（copy number alteration及びsingle nucleotide variant）","en":"whole exome sequencing"},"targets":{"ja":"樹立した9種類のヒト由来中枢神経原発悪性リンパ腫細胞株（PDX；第1～4世代 ）及び中枢神経原発悪性リンパ腫症例の腫瘍組織ならびに末梢血","en":"Nine samples, including patient derived xenograft (PDX) mice, tumor samples and peripheral blood cells from PCNSL patients"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"中枢神経原発悪性リンパ腫2症例の腫瘍組織および末梢血と、腫瘍組織から樹立した2種類（YML9, YML11）のPatient Derived Xenograft（PDX）から抽出したDNAを用いたExome解析結果（copy number alteration及びsingle nucleotide variant）を提供する。","en":"DNAs extracted from tumor cells and peripheral blood cells of two PCNSL patients and patient derived xenograft samples (YML9 and YML11), were used for whole exome sequencing. Copy number alteration and single nucleotide variant data were provided."},"dataProviders":[{"name":{"ja":"山本 哲哉","en":"Tetsuya Yamamoto"},"organization":{"name":{"ja":"横浜市立大学脳神経外科","en":"Department of Neurosurgery, Yokohama City University"}}}],"researchProjects":[{"name":{"ja":"Neurosurgical-Oncology lab, Yokohama City University","en":"Neurosurgical-Oncology lab, Yokohama City University"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"IDH変異神経膠腫のDNA高変異に起因する悪性化回避を目指した治療法の開発","en":"Development of novel therapeutic target for IDH mutant gliomas with DNA hypermutation"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["19K09488"]}],"relatedPublications":[{"title":"A Rapid Genotyping Panel for Detection of Primary Central Nervous System Lymphoma","doi":"https://doi.org/10.1182/blood.2020010137","datasets":["JGAD000259"]},{"title":"A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma","doi":"https://doi.org/10.1158/0008-5472.can-20-2425","datasets":["JGAD000259"]}],"datasets":["JGAD000259"],"controlledAccessUsers":[]}