{"id":"hum0167","version":1,"url":"https://humandbs.dbcls.jp/research/hum0167/v1","datePublished":"2019-07-23","versions":[{"version":1,"datePublished":"2019-07-23"}],"title":{"ja":"痛風・高尿酸血症及び尿酸関連疾患の病態解明に関する研究","en":"Study to clarify the pathophysiology of gout / hyperuricemia and uric acid related diseases"},"summary":{"aims":{"ja":"血清尿酸値（SUA）の変動に関連する遺伝要因を同定する","en":"To clarify the susceptibility genetic loci for serum uric acid (SUA) level"},"methods":{"ja":"GWASメタ解析","en":"GWAS meta analysis"},"targets":{"ja":"3つの日本人コホート研究への参加者（日本多施設共同コホート研究【J-MICC study】：10,621名、北名古屋ゲノム疫学研究【KING study】：2,095名、バイオバンクジャパン【BBJ】：109,029名）","en":"Participants of 3 Japanese cohorts (the Japan Multi-Institutional Collaborative Cohort [J-MICC] study, the KIta Nagoya Genomic epidemiological studies [KING] study, and the Bio Bank Japan [BBJ] study)"},"url":{"ja":[{"url":"https://www.ndmc.ac.jp/med/subject/bunshi/","text":"https://www.ndmc.ac.jp/med/subject/bunshi/"}],"en":null}},"listingSummary":{"methods":{"ja":"ゲノムワイド関連","en":"Genome-wide association study"},"targets":{"ja":"日本人コホート（J-MICC study、KING study、BBJ）：計121,745名\n（日本人）","en":"121,745 participants of 3 Japanese cohorts (J-MICC study, KING study, BBJ)\n(Japanese)"},"typeOfData":{"ja":"SNP-chip","en":"SNP-chip"}},"releaseNote":{"ja":"3つの日本人コホート研究（J-MICC study：10,621名、KING study：2,095名、BBJ：109,029名）それぞれにおいて実施された血清尿酸値の変動値に関するGWASのメタ解析結果を提供する（txt）。","en":"Result of meta analysis of 3 GWASs for SUA level in 3 Japanese cohorts (J-MICC study, KING study, and BBJ) was provided (txt file)."},"dataProviders":[{"name":{"ja":"松尾 洋孝","en":"Hirotaka Matsuo"},"organization":{"name":{"ja":"防衛医科大学校 分子生体制御学講座","en":"Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College"}}}],"researchProjects":[],"grants":[{"title":{"ja":"分子遺伝疫学的解析による痛風の病態解明とゲノムテーラーメイド医療への応用","en":"Investigation of pathophysiology of gout by molecular genetic epidemiological analysis and application to genome-tailored medicine"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["25293145"]},{"title":{"ja":"分子遺伝疫学的解析を活用したヒト腸管上皮における尿酸排泄機構の解明","en":"Evaluation of urate excretion mechanism at human intestinal epithelium using molecular genetic epidemiological analysis"},"agency":{"ja":"科学研究費助成事業 挑戦的萌芽研究","en":"KAKENHI Grant-in-Aid for challenging Exploratory Research"},"grantIds":["15K15227"]},{"title":{"ja":"国際コンソーシアムを活用した日本発の痛風の分子疫学研究による予防医学への応用","en":"Organization of International consortium for gout genetics and development of its preventive medicine"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["17H04128"]},{"title":{"ja":"がん研究分野の特性等を踏まえた支援活動","en":"Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas Study on supports for molecular cohort studies"},"agency":{"ja":"科学研究費助成事業 新学術領域研究（研究領域提案型）","en":"KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)"},"grantIds":["221S0001"]},{"title":{"ja":"分子疫学コーホート研究の支援に関する研究","en":"Study on supports for molecular cohort studies"},"agency":{"ja":"科学研究費助成事業 特定領域研究","en":"KAKENHI Grant-in-Aid for Scientific Research on Priority Areas"},"grantIds":["17015018"]},{"title":{"ja":"コホート・生体試料支援プラットフォーム","en":"Platform of Supporting Cohort Study and Biospecimen Analysis"},"agency":{"ja":"科学研究費助成事業 新学術領域研究（研究領域提案型）『学術研究支援基盤形成』","en":"KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas - Platforms for Advanced Technologies and Research Resources"},"grantIds":["16H06277"]},{"title":{"ja":"生活習慣病の遺伝子リスクマーカーの信頼性に関する検証的疫学研究","en":"Prediction of the genetic and epigenetic risk associated with lifestyle-relatied diseases in the population-based confirmatory factor analysis"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["24390169"]},{"title":{"ja":"生活習慣病の包括的リスク診断アルゴリズムの構築と検証的疫学研究","en":"Prediction of the genetic and epigenetic risks associated with lifestyle-related diseases in the population-based confirmatory factor analysis"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["16H05250"]},{"title":{"ja":"地域住民を対象としたエピゲノム疫学研究基盤の構築","en":"Construction of an epigenetic epidemiology database for a population cohort"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["25293144"]},{"title":{"ja":"発現ネットワーク解析とエピゲノム情報に基づくアディポネクチン発現パスウェイの解明","en":"Elucidation of adiponectin expression pathway based on the co-expression network and epigenome data analysis"},"agency":{"ja":"科学研究費助成事業 若手研究（B）","en":"KAKENHI Grant-in-Aid for Young Scientists (B)"},"grantIds":["15K19242"]},{"title":{"ja":"新たな代謝相関の提案に向けたELOVL2プロモーター領域DNAメチル化制御の解明","en":"Elucidation of the significance of DNA methylation at the ELOVL2 promoter for the proposal of new metabolic correlations"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["18K06942"]}],"relatedPublications":[{"title":"Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals","doi":"https://doi.org/10.1038/s42003-019-0339-0","datasets":["NHA000085"]}],"datasets":["NHA000085"],"controlledAccessUsers":[]}