{"id":"hum0166","version":2,"url":"https://humandbs.dbcls.jp/research/hum0166/v2","datePublished":"2024-01-25","versions":[{"version":1,"datePublished":"2019-07-30"},{"version":2,"datePublished":"2024-01-25"}],"title":{"ja":"炎症性腸疾患患者におけるチオプリン関連副作用とNUDT15遺伝子多型との相関性に関する多施設共同研究（MENDEL Study）","en":"Multicenter Evaluation of NUDT15-R139C genotyping efficiency to DEtect thiopurine-induced hair Loss and leukopenia (MENDEL study)"},"summary":{"aims":{"ja":"チオプリン製剤の副作用に関連する遺伝因子の探索","en":"Discovery of genetic factors associated with thiopurine-induced severe adverse events"},"methods":{"ja":"ゲノムワイド関連解析","en":"Genome-wide association study"},"targets":{"ja":"炎症性腸疾患（クローン病、潰瘍性大腸炎、腸管ベーチェット病）患者","en":"Patients with inflammatory bowel diseases (Crohn's disease, Ulcerative Colitis, Gastrointestinal Behçet's disease)"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"ゲノムワイド関連","en":"Genome-wide association study"},"targets":{"ja":"炎症性腸疾患：1221＋2680症例\n（日本人）","en":"1221 + 2680 patients of Inflammatory bowel disease\n(Japanese)"},"typeOfData":{"ja":"SNP-chip","en":"SNP-chip"}},"releaseNote":{"ja":"炎症性腸疾患2680症例の末梢血から抽出したDNAを対象としたSNPアレイ（Affymetrix Japonica Array v1）データをCELファイルにて提供する。","en":"gDNAs extracted from peripheral blood cells of 2680 patients with inflammatory bowel diseases were genotyped by using of Affymetrix Japonica Array v1. Intensity data were provided as CEL files."},"dataProviders":[{"name":{"ja":"角田 洋一","en":"Yoichi Kakuta"},"organization":{"name":{"ja":"東北大学病院・消化器内科","en":"Tohoku University Hospital, Department of Gastroenterology"}}}],"researchProjects":[{"name":{"ja":"MENDEL study group","en":"MENDEL study group"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"チオプリン不耐例を判別するNUDT15 R139C遺伝子多型検査キットの開発を軸とした炎症性腸疾患におけるゲノム医療実用化フレームワークの確立","en":"Framework development for genomic medicine in inflammatory bowel disease based on the NUDT15 R139C genotyping kit to find the patients intolerant to thiopurines."},"agency":{"ja":"日本医療研究開発機構（AMED） ゲノム創薬基盤推進研究事業","en":"Program for Promoting Platform of Genomics based Drug Discovery, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP18kk0305002"]}],"relatedPublications":[{"title":"NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.","doi":"https://doi.org/10.1007/s00535-018-1486-7","datasets":["NHA000086","JGAD000791"]},{"title":"Genetic Analysis of Ulcerative Colitis in Japanese Individuals Using Population-specific SNP Array","doi":"https://doi.org/10.1093/ibd/izaa033","datasets":["JGAD000791"]},{"title":"Genetic Background of Mesalamine-induced Fever and Diarrhea in Japanese Patients with Inflammatory Bowel Disease.","doi":"https://doi.org/10.1093/ibd/izab004","datasets":["JGAD000791"]}],"datasets":["JGAD000791","NHA000086"],"controlledAccessUsers":[]}