{"id":"hum0157","version":1,"url":"https://humandbs.dbcls.jp/research/hum0157/v1","datePublished":"2019-08-19","versions":[{"version":1,"datePublished":"2019-08-19"}],"title":{"ja":"がんのクリニカルシークエンスと付随研究としての網羅的ゲノム・エピゲノム解析","en":"Cancer clinical sequence and accompanying research for comprehensive genomic and epigenomic analyses"},"summary":{"aims":{"ja":"がんのクリニカルシークエンスおよび付随研究としての網羅的ゲノム・エピゲノム解析","en":"Cancer clinical sequence and accompanying research for comprehensive genomic and epigenomic analyses"},"methods":{"ja":"腫瘍FFPE検体から抽出したDNA、RNA、および対照コントロールとして同一症例の正常血液から抽出したDNAをNextSeq（Illumina）を用いて配列決定した","en":"DNA and RNA from tumor tissues (FFPE) and DNA from normal blood cells were subjected to target capture DNA panel sequencing and RNA panel sequencing by using of NextSeq (Illumina)."},"targets":{"ja":"183症例のがん（肺がん53例、肉腫39例、大腸がん24例、子宮がん15例、卵巣がん12例、子宮肉腫8例、下咽頭癌4例、腺様嚢胞がん4例、原発不明がん5例、その他組織型のがん19例）","en":"183 cancer cases (lung cancer: 53, soft tissue sarcoma: 39, colon cancer: 24, endometrial cancer: 15, ovarian cancer: 12, endometrial sarcoma: 8, hypopharyngeal cancer: 4, adenoid cystic carcinoma: 4, cancer of unknown primary: 5, other types of cancer: 19)"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"癌：183症例\n（日本人）","en":"183 cancer patients\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Target Capture）","en":"NGS\n(Target Capture)"}},"releaseNote":{"ja":"腫瘍FFPE検体から抽出したDNA, RNA、および対照コントロールとして同一症例の正常血液から抽出したDNAを用いたTarget Capture解析結果をfastqファイルにて提供する。NextSeq（Illumina）によるDNAパネルおよびRNAパネルを用いた配列決定を実施した。","en":"DNA and RNA from tumor tissues (FFPE) and DNA from normal blood cells were subjected to target capture DNA panel and RNA panel by NextSeq (Illumina). Fastq files were provided."},"dataProviders":[{"name":{"ja":"宮園 浩平","en":"Kohei Miyazono"},"organization":{"name":{"ja":"東京大学大学院医学系研究科 分子病理学分野","en":"Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo"}}}],"researchProjects":[],"grants":[{"title":{"ja":"大規模ゲノム医療体制の確立と知識データベースの構築","en":"Establishment of infrastructure for genomic medicine and construction of knowledge database"},"agency":{"ja":"日本医療研究開発機構（AMED） 臨床ゲノム情報統合データベース整備事業","en":"Program for an Integrated Database of Clinical and Genomic Information, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP18kk0205003"]},{"title":{"ja":"がん治療標的探索プロジェクト","en":"Project for Exploration of Cancer Therapeutic Targets"},"agency":{"ja":"日本医療研究開発機構 革新的先端研究開発支援事業インキュベートタイプ（AMED-LEAP）","en":"Leading Advanced Projects for medical innovation, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-LEAP)"},"grantIds":["JP18am0001001"]},{"title":{"ja":"革新的がん遺伝子機能解析法によるプレシジョンメディシンの実現","en":"Implementation of precision medicine by the application of an innovative method for functional evaluation of oncogenes."},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP18ck0106252"]},{"title":{"ja":"ヒト上皮性腫瘍の発生・進展機構の解明と新規治療標的の同定","en":"Elucidation of initiation and progression mechanism of human epithelial tumors towards identification of novel therapeutic targets"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん医療創生研究事業（P-CREATE）","en":"Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP18cm0106502"]}],"relatedPublications":[{"title":"Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens.","doi":"https://doi.org/10.1111/cas.13968","datasets":["JGAD000242"]},{"title":"MicroSEC filters sequence errors for formalin-fixed and paraffin-embedded samples","doi":"https://doi.org/10.1038/s42003-021-02930-4","datasets":["JGAD000242"]}],"datasets":["JGAD000242"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"中岡 博史","en":"Hirofumi Nakaoka"},"affiliation":{"ja":"腫瘍ゲノム研究部, 公益財団法人佐々木研究所","en":"Department of Cancer Genome Research, Sasaki Institute"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"肺がん遺伝子解析研究","en":"Genetic analysis of lung cancer"},"periodStart":"2022-08-17","periodEnd":"2026-07-23","datasets":["JGAD000242"]}]}