{"id":"hum0147","version":1,"url":"https://humandbs.dbcls.jp/research/hum0147/v1","datePublished":"2020-05-25","versions":[{"version":1,"datePublished":"2020-05-25"},{"version":2,"datePublished":"2022-02-18"},{"version":3,"datePublished":"2023-05-08"}],"title":{"ja":"制御性T細胞特異的エピゲノム誘導による免疫制御の研究","en":"Immune regulation by cotrolling regulatory T cell-specific epigenome"},"summary":{"aims":{"ja":"制御性T細胞（Treg）特異的エピゲノムの解析、ならびに、がん、自己免疫疾患における免疫担当細胞の解析","en":"Analysis of epigenetic status of regulatory T cells (Treg) and analysis of immune cells in cancers and autoimmune diseases"},"methods":{"ja":"RNA-seq、ChIP-seq、PBAT-seq、ATAC-seq、single cell RNA-seq、bulk RNA-seq","en":"RNA-seq, ChIP-seq, PBAT-seq, ATAC-seq, single cell RNA-seq, and bulk RNA-seq"},"targets":{"ja":"健常人4名（STR1、STR5、STR6、BDR1）、がん患者7＋3症例","en":"Healthy donors and cancer patients"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"健常人4名の末梢血5分画（Fr1：naive Treg、Fr2：effector Treg、Fr3：Foxp3+ effector conventional T cells、Fr5：effector conventional T cells、Fr6：naive T cells）から抽出したDNA/RNAを対象としたRNA-seq、ChIP-seq（H3K27ac）、PBAT-seq、ATAC-seqを行った結果を提供する。","en":"DNA/RNA extracted from 5 fractions from peripheral blood cells of healthy individuals (Fr1: naive Treg, Fr2: effector Treg, Fr3: Foxp3+ effector conventional T cells, Fr5: effector conventional T cells, Fr6: naive T cells) were used for RNA-seq, ChIP-seq, PBAT-seq, and ATAC-seq analyses."},"dataProviders":[{"name":{"ja":"坂口 志文","en":"Shimon Sakaguchi"},"organization":{"name":{"ja":"大阪大学 免疫学フロンティア研究センター 実験免疫学","en":"Experimental Immunology, IFReC, Osaka University"}}}],"researchProjects":[],"grants":[{"title":{"ja":"制御性T細胞の分化に必須な特異的エピゲノム形成機構の解明","en":"Clarification of regulatory T cell-specific epigenome"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["15H04744"]},{"title":{"ja":"制御性T細胞による免疫応答制御の包括的研究","en":"Study of the function and development of regulatory T cells"},"agency":{"ja":"科学研究費助成事業 特別推進研究","en":"Grant-in-Aid for Specially Promoted Research"},"grantIds":["16H06295"]},{"title":{"ja":"制御性T細胞による慢性炎症制御技術の開発","en":"Devising novel methods to control chronic inflammation via regulatory T cells"},"agency":{"ja":"日本医療研究開発機構 革新的先端研究開発支援事業（AMED-CREST）","en":"Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST)"},"grantIds":["JP17gm0410016"]},{"title":{"ja":"制御性T細胞を標的とした免疫応答制御技術に関する研究開発","en":"Study of Immunoregulatory technology targeting regulatory T cells"},"agency":{"ja":"日本医療研究開発機構 革新的先端研究開発支援事業インキュベートタイプ（AMED-LEAP）","en":"Leading Advanced Projects for medical innovation, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-LEAP)"},"grantIds":["JP18gm0010005"]}],"relatedPublications":[{"title":"Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases","doi":"https://doi.org/10.1016/j.immuni.2020.04.006","datasets":["JGAD000214"]},{"title":"CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory","doi":"https://doi.org/10.1073/pnas.2114282119","datasets":["JGAD000423"]}],"datasets":["JGAD000214"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000214","JGAD000423"]},{"principalInvestigator":{"ja":"高地 雄太","en":"Yuta Kochi"},"affiliation":{"ja":"難治疾患研究所ゲノム機能多様性分野, 東京医科歯科大学","en":"Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"機能性遺伝子多型の網羅的解析を介した多因子疾患の病態解明","en":"Genetic study of complex diseases through comprehensive analysis of functional genetic variations"},"periodStart":"2023-04-12","periodEnd":"2028-03-31","datasets":["JGAD000214"]}]}