{"id":"hum0143","version":1,"url":"https://humandbs.dbcls.jp/research/hum0143/v1","datePublished":"2025-05-12","versions":[{"version":1,"datePublished":"2025-05-12"}],"title":{"ja":"膵臓癌の進展において(プロ)レニン受容体の発現亢進は、クロマチンリモデラーSMARCA5の発現増大を介してゲノム不安定性を生じる","en":"Aberrant (pro)renin receptor expression induces genomic instability by chromatin remodeler SMARCA5 disruption during the pancreatic ductal adenocarcinoma"},"summary":{"aims":{"ja":"膵臓がんを発生させるヒト膵管上皮細胞に、（プロ）レニン受容体を過剰発現させることによって、全ゲノムレベルでゲノム不安定性を生じることを明らかにする。","en":"The aim of the present study is to elucidate whether aberrant (P)RR expression induces genomic instability in human pancreatic ductal epithelial (HPDE) cells, which are transforming into pancreatic ductal adenocarcinoma (PDAC)."},"methods":{"ja":"（プロ）レニン受容体を過剰発現させた細胞とコントロール細胞のヒト全ゲノム比較解析","en":"Comparative analysis of the human whole genome between HPDE cells overexpressed by(pro)renin receptor and control HPDE cells"},"targets":{"ja":"不死化ヒト膵管上皮細胞（Human pancreatic ductal epithelial：HPDE）","en":"Immortalized human pancreatic ductal epithelial (HPDE) cells"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"不死化ヒト膵管上皮細胞：6検体\n（細胞株）","en":"Human pancreatic ductal epithelial cells: 6 samples\n(Cell-line)"},"typeOfData":{"ja":"NGS\n（WGS）","en":"NGS\n(WGS)"}},"releaseNote":{"ja":"（プロ）レニン受容体を過剰発現させた不死化ヒト膵管上皮細胞から抽出したDNAを用いたwhole genome sequencing解析データをfastqファイル形式で提供する。","en":"DNAs extracted from (P)RR-expressing HPDE cells were used for the whole genome sequencing analyses. Fastq files are provided."},"dataProviders":[{"name":{"ja":"西山 成","en":"Akira Nishiyama"},"organization":{"name":{"ja":"香川大学 医学部薬理学","en":"Department of Pharmacology, Faculty of Medicine, Kagawa Universty"}}}],"researchProjects":[],"grants":[{"title":{"ja":"腎臓が引き起こす生体老化の機序解明とその制御","en":"Kidney-mediated aging process"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["18H03191"]},{"title":{"ja":"（プロ）レニン受容体を介した膵管癌の進化メカニズムの解明","en":"Evolutionary machanism of pancreatic ductal adenocarcinoma mediated by (pro)renin receptor"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["19K07690"]},{"title":{"ja":"膵臓がん形成における（プロ）レニン受容体 の機能解析","en":"Functional analysis of (pro)renin receptor in the genesis of pancreatic cancer"},"agency":{"ja":"科学研究費助成事業 挑戦的萌芽研究","en":"KAKENHI Grant-in-Aid for challenging Exploratory Research"},"grantIds":["16K14610"]},{"title":{"ja":"生活習慣病に対する新規治療薬の開発","en":"Development of new therapeutic agents for lifestyle-related diseases"},"agency":{"ja":"公益財団法人篷庵社/香川大学医学部医学科同窓会 讃樹會","en":"Hoansha Foundation and Alumni Association of Kagawa University (Sanjukai)"},"grantIds":null},{"title":{"ja":"膵臓がんの早期マーカーとしての可溶性（プロ）レニン受容体の有用性の検討","en":"Examination of the availability of soluble (pro)renin receptor as an early marker of pancreatic cancer"},"agency":{"ja":"東京バイオマーカー・イノベーション技術研究組合 TOBIRA研究助成","en":"TOBIRA, Tokyo Biomarker Innovation Research Associate"},"grantIds":null}],"relatedPublications":[{"title":"Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H","doi":"https://doi.org/10.1038/s42003-020-01434-x","datasets":["JGAD000212"]}],"datasets":["JGAD000212"],"controlledAccessUsers":[]}